A5026705439- Tryptophan and brain disorders
- Gut microbiota and health
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Bacteriophages and microbial interactions
- Dietary Effects on Health
- Tensor decomposition and applications
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Immune Response and Inflammation
- Nutrition, Genetics, and Disease
- Clostridium difficile and Clostridium perfringens research
- Psoriasis: Treatment and Pathogenesis
- Viral Infections and Immunology Research
- Macrophage Migration Inhibitory Factor
- Alzheimer's disease research and treatments
- Lymphoma Diagnosis and Treatment
Weizmann Institute of Science
2019-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2019
Experimental Medicine and Biology Institute
2018-2019
Academia Nacional de Medicina
2014-2018
Centre National de la Recherche Scientifique
2018
Administración Nacional de Laboratorios e Institutos de Salud
2018
New York Academy of Medicine
2018
Czech Academy of Sciences, Institute of Experimental Medicine
2018
Universidad Nacional de La Plata
2018
The tuberculosis (TB) bacillus, Mycobacterium (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates pathogenesis are not well known. Using in vitro ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present TB-associated microenvironment, produce high levels of HIV-1. In vivo, macrophages expanded lungs co-infected non-human primates, correlates with disease severity. Furthermore, HIV-1/Mtb patients display an...
People with diabetes feature a life-risking susceptibility to respiratory viral infection, including influenza and SARS-CoV-2 (ref.
The ability of Mycobacterium tuberculosis (Mtb) to persist in its human host relies on numerous immune evasion strategies, such as the deregulation lipid metabolism leading formation foamy macrophages (FM). Yet specific factors phenotype Mtb-infected remain unknown. Herein, we aimed address whether cytokines contribute FM context Mtb infection. Our approach is based use an acellular fraction tuberculous pleural effusions (TB-PE) a physiological source local released during We found that...
Longitudinal ’omics analytical methods are extensively used in the evolving field of precision medicine, by enabling ‘big data’ recording and high-resolution interpretation complex datasets, driven individual variations response to perturbations such as disease pathogenesis, medical treatment or changes lifestyle. However, inherent technical limitations biomedical studies often result generation feature-rich sample-limited datasets. Analyzing data using conventional modalities proves be...
Bacteriophages have potential as suppressors of disease-contributing commensal bacteria.
Circulating monocytes (Mo) play an essential role in the host immune response to chronic infections. We previously demonstrated that CD16(pos) Mo were expanded TB (tuberculosis) patients, correlated with disease severity and refractory dendritic cell differentiation. In present study, we investigated whether human subsets (CD16(neg) CD16(pos)) differed their ability influence early inflammatory against Mycobacterium tuberculosis. first evaluated capacity of migrate engage a microbicidal...
Fil: Colado, Ana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto Medicina Experimental. Academia Buenos Aires. Experimental; Argentina
We have reported previously that T cells from patients with multi-drug-resistant tuberculosis (MDR-TB) express high levels of interleukin (IL)-17 in response to the MDR strain M (Haarlem family) Mycobacterium (M. tuberculosis). Herein, we explore pathways involved induction Th17 MDR-TB and healthy tuberculin reactors [purified protein derivative donors (PPD+ HD)] by laboratory H37Rv. Our results show IL-1β IL-6 are crucial for H37Rv M-induced expansion IL-17+ interferon (IFN)-γ- IFN-γ+ CD4+...
In human tuberculosis (TB), CD8+ T cells contribute to host defense by the release of Th1 cytokines and direct killing Mycobacterium (Mtb)-infected macrophages via granule exocytosis pathway or engagement receptors on target cells. Previously we demonstrated that strain M, most prevalent multidrug-resistant (MDR) Mtb in Argentine, is a weak inducer IFN-γ elicits remarkably low CD8-dependent cytotoxic cell activity (CTL). contrast, closely related 410, which caused unique case MDR-TB, CTL...
M strain, the most prevalent multidrug-resistant strain of Mycobacterium tuberculosis (Mtb) in Argentina, has mounted mechanisms to evade innate immune response. The role human bronchial epithelium Mtb infection remains unknown as well its crosstalk with neutrophils (PMN). In this work, we evaluate whether and H37Rv strains invade replicate within epithelial cell line Calu-6 how conditioned media (CM) derived from infected cells alter PMN responses. We demonstrated that infects survives...
The incidence of age-related dementia is growing with increased longevity, yet there are currently no disease-modifying therapies for these devastating disorders. Studies over the last several years have led to an evolving awareness role immune system in supporting brain maintenance and repair, displaying a diverse repertoire functions while orchestrating crosstalk between periphery brain. Here, we provide insights into current understanding therapeutic targets that could be adopted modulate...
The tuberculosis (TB) bacillus, Mycobacterium (Mtb) and HIV-1 are known to act synergistically, however, the mechanisms by which Mtb exacerbates pathogenesis not well known. Here, using in vitro ex vivo cell culture system, we show that human M(IL-10) anti-inflammatory macrophages, present TB-associated microenvironments, produced high levels of HIV-1. These macrophages form direct cell-to-cell bridges, identified as tunneling nanotubes (TNTs). TNT formation required IL-10/STAT3 signaling...