A5111164832- Lung Cancer Treatments and Mutations
- Advanced Neuroimaging Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- HER2/EGFR in Cancer Research
- Advanced MRI Techniques and Applications
- Signaling Pathways in Disease
- Chronic Myeloid Leukemia Treatments
- Analytical chemistry methods development
- Drug Transport and Resistance Mechanisms
- Acute Ischemic Stroke Management
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Ion Transport and Channel Regulation
- MRI in cancer diagnosis
- Ophthalmology and Eye Disorders
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Gastrointestinal Tumor Research and Treatment
- Thermoregulation and physiological responses
- Advanced X-ray Imaging Techniques
- Ocular Surface and Contact Lens
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrochemical sensors and biosensors
- Ultrasound Imaging and Elastography
Dalian Medical University
2016-2025
First Affiliated Hospital of Dalian Medical University
2016-2025
Shanghai Jiao Tong University
2012-2025
XinHua Hospital
2012-2025
China Agricultural University
2007-2024
Lushan Botanical Garden
2023-2024
Baotou Medical College
2021-2023
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2023
AstraZeneca (United Kingdom)
2023
Emory University
2008-2022
Abstract Purpose: Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing T790M resistance mutations. To treat metastatic brain disease, blood–brain barrier (BBB) permeability considered desirable for increasing clinical efficacy. Experimental Design: We examined the level penetration 16 irreversible reversible EGFR-TKIs using multiple in vitro vivo BBB preclinical models. Results: In osimertinib was weakest substrate human efflux transporters...
Abstract Hepatocellular carcinoma (HCC) is refractory to chemotherapies, necessitating novel effective agents. The lysosome inhibitor Bafilomycin A1 (BafA1) at high concentrations displays cytotoxicity in a variety of cancers. Here we show that BafA1 nanomolar suppresses HCC cell growth both 2 dimensional (2D) and 3D cultures. induced cycle arrest the G1 phase triggered Cyclin D1 turnover cells dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) dependent manner. Notably,...
Abstract Mps one binder 2 (MOB2) regulates the NDR kinase family, however, whether and how it is implicated in cancer remain unknown. Here we show that MOB2 functions as a tumor suppressor glioblastoma (GBM). Analysis of expression glioma patient specimens bioinformatic analyses public datasets revealed was downregulated at both mRNA protein levels GBM. Ectopic suppressed, while depletion enhanced, malignant phenotypes GBM cells, such clonogenic growth, anoikis resistance, formation focal...
Applying natural food additives extracted from plants is a sustainable development trend in the industry. Compared with synthetic additives, plant-based have garnered considerable attention owing to their advantages such as green safety, health, and environmental protection. Therefore, utilization of becoming most active field future direction for However, there are several problems associated large-scale production application, more studies required evaluate potential side effects safety...
Temporal-statistical analysis of laser-speckle image (TS-LSI) preserves the original spatial resolution, in contrast to conventional spatial-statistical (SS-LSI). Concerns have been raised regarding temporal independency TS-LSI signals and its insensitivity toward stationary-speckle contamination. Our results from flow phantoms vivo rat retinas demonstrated that are temporally statistically independent minimizes The latter is because stationary speckle "non-random" thus non-ergodic where...
The inhibition of ataxia-telangiectasia mutated (ATM) has been shown to chemo- and radio-sensitize human glioma cells in vitro therefore might provide an exciting new paradigm the treatment glioblastoma multiforme (GBM). effective GBM will likely require a compound with potential efficiently cross blood–brain barrier (BBB). Starting from clinical candidate AZD0156, 4, we investigated imidazoquinolin-2-one scaffold goal improving CNS exposure humans. Strategies aimed at reducing hydrogen...
Abstract Background The purpose of the present study was to investigate effect and potential mechanism chlorogenic acid (CA) on liver injury induced by cholestasis in a rat model bile duct ligation (BDL). Methods Rats received vehicle or CA (20, 50, 100 mg/kg per day) orally for 3 days. On 4th day, rats underwent sham BDL surgery, were administrated 7 mRNA protein expression levels evaluated qRT‐PCR western blot. Results After BDL, plasma alanine aminotransferase (ALT), aspartate (AST),...
Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain Ajuba regulates YAP is implicated in tumorigenesis. However, roles mechanism expression HCC cells remain unclear. E3 ligase Hakai shown to interact other family members whether interacts unknown. cell lines stably depleted or were established using lentiviruses expressing shRNAs against Hakai. effects on determined by a...
To facilitate the design of drugs readily able to cross blood brain barrier (BBB), a Madin-Darby canine kidney (MDCK) cell line was established that over expresses both P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP), main human efflux transporters BBB. Proteomics analyses indicate BCRP is expressed at higher level than Pgp in this line. This shows good activity for [BCRP substrate dantrolene ratio (ER) 16.3 ± 0.9, quinidine ER 27.5 1.2], use selective transporter inhibitors...
Abstract Maize samples (n = 309) containing 3090 single intact kernels from a broad variety of breeding materials were scanned by Near Infrared Reflectance Spectroscopy (NIRS) to develop non‐destructive determination calibrations for crude protein, starch and oil content in kernels. Calibration equations developed partial least square regression (PLS). Regression parameters between the chemical values, determined reference methods, predicted Spectroscopy, verified cross validation external...
Background and Purpose Diffusion-weighted imaging (DWI) perfusion MRI were used to examine the spatiotemporal evolution of stroke lesions in adult macaques with ischemic occlusion. Methods Permanent MCA occlusion was induced silk sutures through an interventional approach via femoral artery rhesus monkeys (n = 8, 10–21 years old). The examined high-resolution DWI MRI, T2-weighted (T2W) on a clinical 3T scanner at 1–6, 48, 96 hours post validated H&E staining. Results infarct evolved natural...
Abstract Background FK506-binding protein 9 (FKBP9) is amplified in high-grade gliomas (HGGs). However, the roles and mechanism(s) of FKBP9 glioma are unknown. Methods The expression clinical tissues was detected by immunohistochemistry (IHC). correlation between levels prognosis patients examined bioinformatic analysis. Glioblastoma (GBM) cell lines stably depleted were established using lentiviruses expressing shRNAs against FKBP9. effects on GBM cells determined cell-based analyses,...
This study aims to explore the potential of machine learning as a non-invasive automated tool for skin tumor differentiation. Data were included from 156 lesions, collected retrospectively September 2021 February 2024. Univariate and multivariate analyses traditional clinical features performed establish logistic regression model. Ultrasound-based radiomics are extracted grayscale images after delineating regions interest (ROIs). Independent samples t-tests, Mann-Whitney U tests, Least...
Detection of hypsarrhythmia electroencephalography (EEG) in infants with West syndrome (WS) is currently performed by manual inspection long-term video/EEG recording, producing low inter-rater reliability. Existing studies aiming at exploring digital biomarkers for EEG focus mainly on the temporal and spectral features. The aim present study to explore spatial distribution connection analysing brain functional connectivity (BFC) WS patients thus identify possible EEG. To this end,...
In this paper, a simple and innovative colorimetric method is established, which based on DBP-induced aggregation of arginine functionalized gold nanoparticles (ARG-AuNPs), can be used for the sensitive determination dibutyl phthalate (DBP) in Baijiu samples.
Herein, we report the preparation of a gold nanoparticle-thioglycolic acid (TGA@AuNP) suspension for label-free colorimetric detection organophosphorus pesticide chlorpyrifos.
Myocardial stunning, which is closely related to myocardial edema, a severe complication that may occur following cardiac surgery. In this study, we examined the expression of aquaporin 1 (AQP1) and Connexin 43 (Cx43) cardiopulmonary bypass (CPB) surgery in goats. We assessed muscle tissue water content according changes dry-wet weight. Our results showed AQP1 increased significantly 6 h after CPB surgery, reaching peak levels 48 surgery; additionally, protein Cx43 was inversely correlated...
Many MRI parameters have been explored and demonstrated the capability or potential to evaluate acute stroke injury, providing anatomical, microstructural, functional, neurochemical information for diagnostic purposes therapeutic development. However, application of multiparameter approach is hindered in clinic due very limited time window after insult. Parallel imaging technique can accelerate data acquisition dramatically has incorporated modern clinical scanners increasingly applied...
Based on uncertainty measure theory, a stability classification and order-arranging model of surrounding rock was established. Considering the practical engineering geologic condition, 5 factors that influence were taken into account function obtained based in situ data. In this model, analyzed quantitatively qualitatively real situation; weight index given information entropy theory; level judged credible degree recognition criterion; ordered criterion. Furthermore, employed to evaluate...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most frequent autoimmune in children, and its presentation various. The disease can be triggered by various infections.Case 1 was a 7-year-old female with of seizure, repeated fever, language disorder, decreased muscle strength right limbs; Case 2 male manifestation emesis, headache, involuntary movement, altered personality, seizures, cognitive impairment; 3 2-year-old coma, limbs. Anti-NMDAR antibody identified cerebrospinal...