A5102827229- Peptidase Inhibition and Analysis
- HIV Research and Treatment
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Enzyme Structure and Function
- Antimicrobial Peptides and Activities
- HIV, Drug Use, Sexual Risk
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Clinical Reasoning and Diagnostic Skills
- Cancer, Lipids, and Metabolism
- Innovations in Medical Education
- Simulation-Based Education in Healthcare
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Medical Education and Admissions
- Hepatitis B Virus Studies
- Histone Deacetylase Inhibitors Research
- Genomics, phytochemicals, and oxidative stress
- HIV, TB, and STIs Epidemiology
- Pelvic floor disorders treatments
- Natural Compounds in Disease Treatment
- Tuberculosis Research and Epidemiology
Shanghai Institute of Materia Medica
2022-2025
Chinese Academy of Sciences
2022-2025
Gansu Provincial Center for Disease Control and Prevention
2013-2025
State Key Laboratory of Drug Research
2025
Nanjing University of Chinese Medicine
2022-2024
University of Chinese Academy of Sciences
2024
Fudan University
2024
Nanjing University
2024
First Affiliated Hospital of Jinan University
2015-2023
Nanjing Tech University
2018-2021
BackgroundModern medical education promotes students' clinical operating capacity rather than the mastery of theoretical knowledge. To accomplish this objective, skill training using various simulations was introduced into to cultivate creativity and develop practical ability students. However, quantitative analysis efficiency with is lacking.MethodsIn present study, we compared mean scores students (Jinan University) who graduated in 2013 2014 on 16 stations between traditional (control)...
The purpose of this study was to analyze the epidemiological characteristics and spatial-temporal distribution hepatitis C in Fujian Province, China, from 2015 2022, provide reference for risk identification, early warning prevention control measures Province. incidence data Province 2022 were collected China Information System Disease Control Prevention. Descriptive epidemiology method JRP 4.9.1.0 software used 2022. ArcGIS 10.8 spatial autocorrelation analysis reported C, SaTScan 10.1.3...
Molecular glue (MG) degraders, small molecules with significant therapeutic potential for targeting undruggable proteins, are emerging as new modality in drug discovery. Profiling the E3 ligase interactome induced by MG degraders provides insights into their mechanism of action and identifies clinically relevant neo‐substrates degradation, thereby offering opportunities. However, established methods face challenges comprehensive accurate profiling degrader‐induced interactome. Herein, we...
Molecular glue (MG) degraders, small molecules with significant therapeutic potential for targeting undruggable proteins, are emerging as new modality in drug discovery. Profiling the E3 ligase interactome induced by MG degraders provides insights into their mechanism of action and identifies clinically relevant neo‐substrates degradation, thereby offering opportunities. However, established methods face challenges comprehensive accurate profiling degrader‐induced interactome. Herein, we...
Lysine acylation has been extensively investigated due to its regulatory role in a diverse range of biological functions across prokaryotic and eukaryotic species. In-depth acylomic profiles have the potential enhance comprehension implications organisms. However, extent research on global microorganisms is limited. Here, four lysine acylomes were conducted Bacillus thuringiensis by using LC-MS/MS based proteomics combined with antibody-enrichment strategies, total 3438 acetylated sites,...
Targeting histone epigenetic modification is an important strategy for anticancer therapy. Histone deacetylase inhibitors (HDACis) have been clinically approved in the treatment of diverse hematological cancers, but mechanisms drug resistance and poor therapeutic efficacy solid malignancies remain largely unknown. In this study, we applied a mass spectrometry-based quantitative proteomic to investigate molecular differences HDACi vorinostat (SAHA) sensitive resistant cell lines. The results...
Backgrounds Training in the basic interview skills of clinical history-taking has always been a significant component medical education. Purpose This study was designed to identify factors influence students’ learning and develop way improve these skills. Methods We firstly analysed academic performance students at Jinan University School Medicine different disciplines Clinical Level Test (CMLT), ensure have obtained comprehensive education prior beginning their internships. Next, we...
BackgroundAt the end of 2009, a total 501 AIDS patients were receiving antiretroviral therapy (ART) in Fujian Province China, yet there no assessments to determine treatment efficacy and HIV-1 preventive potency under current health care delivery system. MethodsDuring period 2005–2009, we assessed outcomes initial ART by following up 381 for 12 months Province. CD4+ T-lymphocyte (CD4) count, plasma viral load (VL), patient characteristics analysed. The results compared between 4 groups...
A great number of overseas students have studied medicine at Jinan University Medical School over the past decade. Statistics from ten years show that these students’ test scores on diagnosis and I & II are lower than those their classmates mainland China. To address underlying causes this phenomenon, we implemented a series questionnaires for Chinese medical students. The results indicate there no significant differences between with regard to attitude towards study medicine, approval...
目的 了解福建省艾滋病病毒感染者/艾滋病（HIV/AIDS）病例生存状况的分布特征，探讨生存时间的影响因素。 方法 将1987年1月1日 — 2 017年12月31日符合条件的福建省HIV/AIDS诊断病例共计12 079例纳入研究队列，采用回顾性队列研究方法收集HIV/AIDS病例生存状况的相关信息，计算病例的全死因死亡率和标化死亡率。通过寿命表法和Kaplan-Meier法计算病例的生存率和生存时间，利用Cox比例风险模型探索病例生存时间的影响因素。 结果 福建省HIV/AIDS病例的全死因死亡率为5.37/100人.年（95 % CI = 5.10～5.64），标化全死因死亡率7.99/100人.年（95 7.40～8.58）。HIV/AIDS病例的平均生存时间为17.0年（95 16.1～17.9），1、5、10和15年的生存率分别为92 %、82 %、73 %和68...