A5066807605- Wnt/β-catenin signaling in development and cancer
- Hair Growth and Disorders
- Hippo pathway signaling and YAP/TAZ
- Skin and Cellular Biology Research
- Cellular Mechanics and Interactions
- Cancer and Skin Lesions
- Melanoma and MAPK Pathways
- Cancer Cells and Metastasis
- Sphingolipid Metabolism and Signaling
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Gut microbiota and health
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Skin Protection and Aging
- Cytokine Signaling Pathways and Interactions
- Molecular Sensors and Ion Detection
- Cancer-related Molecular Pathways
- Advanced Chemical Sensor Technologies
- Pancreatic and Hepatic Oncology Research
- Sulfur Compounds in Biology
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
University of Cincinnati Medical Center
2013-2025
Harbin Medical University
2023-2025
ShanghaiTech University
2025
University of Cincinnati
2015-2024
Peking University
2021-2024
Kunming Medical University
2024
Peking University First Hospital
2021-2024
Xinxiang Medical University
2024
Affiliated Hospital of Southwest Medical University
2024
Xiamen University
2024
Activation of CXCL12/CXCR4 axis has been found to be associated with invasion and metastasis in many cancers. However, the underlying mechanism remains elusive. Increasing data highlight that non-coding RNAs are linked CRC progression. The effects CXCR4 were investigated using villin-CXCR4 transgenic mice model by flow cytometry assay, immunohistochemistry, Western blot. was explored through bioinformatics, luciferase reporter assay RNA immunoprecipitation assay. We high expression...
Despite the uniform mortality in pancreatic adenocarcinoma (PDAC), clinical disease heterogeneity exists with limited genomic differences. A highly aggressive tumor subtype termed 'basal-like' was identified to show worse outcomes and higher inflammatory responses. Here, we focus on microbial effect PDAC progression present a comprehensive analysis of microbiome different subtypes resectable tumors using metagenomic sequencing. We found distinctive communities basal-like an increasing...
beta-Catenin signaling is required for hair follicle development, but it unknown whether its activation sufficient to globally program embryonic epidermis fate. To address this, we mutated endogenous epithelial beta-catenin a dominant-active form in vivo. Hair placodes were expanded and induced prematurely activated mutant embryos, failed invaginate or multilayered structures. Eventually, the entire adopted fate, broadly expressing shaft keratins place of epidermal stratification proteins....
β-catenin is a multifunctional protein that plays crucial roles in embryonic development, physiological homeostasis, and wide variety of human cancers. Previously, we showed vivo targeted ablation melanoma-associated fibroblasts after melanoma formation significantly suppressed tumor growth. However, when the expression was ablated before initiation, development surprisingly accelerated. How stromal deficiency leads to opposite biological effects progression not completely understood. Here,...
The tumor stroma and its cellular components are known to play an important role in response treatment. Here, we report a novel resistance mechanism melanoma that is elicited by BRAF inhibitor (BRAFi)-induced noncanonical activation of nuclear β-catenin signaling cancer-associated fibroblasts (CAF). Treatment with BRAFi leads expanded CAF population increased accumulation enhanced biological properties. This subpopulation essential for cells proliferate acquire BRAFi/MEK inhibitors (MEKi)....
Abstract The hallmark of epithelial-to-mesenchymal transition (EMT) is the switch from epithelial cadherin (E-cadherin) to neural (N-cadherin), allowing melanoma cells form a homotypic N-cadherin-mediated adhesion with stromal fibroblasts. However, how switching initiated, maintained, and regulated in remains elusive. Here, we report novel mechanism underlying that by Yes-associated protein 1 (YAP1) signaling. progression BRAF-mutant mouse was suppressed vivo upon YAP1 ablation...
Abstract The Fas-associated death domain protein (FADD)/Mort1 is a signaling adaptor which mediates the activation of caspase 8 during receptor-induced apoptosis. Disruption FADD in germ cells results receptor-independent embryonic lethality mice. Previous studies indicated that addition to its function apoptosis, also required peripheral T cell homeostasis and TCR-induced proliferative responses. In this report, we generated B cell-specific FADD-deficient mice showed deletion at pro-B stage...
Abstract Stromal fibroblasts are an integral part of the tumor stroma and constantly interact with cancer cells to promote their initiation progression. However, role function dermal during early stage melanoma development remain poorly understood. We, therefore, designed a novel genetic approach deactivate stromal at onset formation by targeted ablation β ‐catenin. To our surprise, tumors formed from ‐catenin‐deficient group (B16F10 mixed fibroblasts) appeared earlier than control normal...
Phenolic acids are the main active ingredients in Salvia miltiorrhiza, which can be used for treatment of many diseases, particularly cardiovascular diseases. It is known that salicylic acid (SA) enhance phenolic content, but molecular mechanism its regulation still unclear. Nonexpresser PR genes 1 (NPR1) plays a positive role SA signaling pathway. In this study, we identified SmNPR1 gene responds to induction and systematically investigated function. We found positively affected...
Breast cancer is the most common affecting women across world. Tumor endothelial cells (TECs) and malignant are major constituents of tumor microenvironment (TME), but their origin role in shaping disease initiation, progression, treatment responses remain unclear due to significant heterogeneity.Tissue samples were collected from eight patients presenting with breast cancer. Single-cell RNA sequencing (scRNA-seq) analysis was employed investigate presence distinct cell subsets...
Abstract Fas-associated death domain protein (FADD)/mediator of receptor-induced toxicity-1 is required for signaling induced by receptors such as Fas. In earlier studies, FADD-deficient mice died in utero, and a FADD deficiency embryonic stem cells inhibited T cell production viable FADD−/−→RAG-1−/− chimeras. To analyze the temporal requirement development function lineage, it necessary to establish mutant producing detectable cells. We generated that express functional FADD:GFP fusion gene...
Haired skin is a defining characteristic of mammals. However, some specialized regions, such as human palms, soles and ventral wrist, mouse plantar foot, are entirely hairless. Using model system, we show that the endogenous secreted Wnt inhibitor DKK2 suppresses hair follicle development permits formation hairless skin. Plantar retains all mechanistic components needed for development, genetic deletion Dkk2 fully functional follicles give rise to external hair, contain sebaceous glands stem...
The hair follicle dermal papilla (DP) contains a unique prominin-1/CD133-positive (CD133+) cell subpopulation, which has been shown to possess follicle-inducing capability. By assaying for endogenous CD133 expression and performing lineage tracing using CD133-CreERT2; ZsGreen1 reporter mice, we find that is expressed in subpopulation of DP cells during the growth phase murine cycle (anagen), but absent at anagen onset. However, how CD133+ interact with keratinocytes induce regenerative...
Abstract Background Cultured human skin models have been widely used in the evaluation of dermato‐cosmetic products as alternatives to animal testing and expensive clinical testing. The most common vitro culture approach is maintain biopsies an airlifted condition at interface supporting medium air phase. This type ex vivo explant not, however, adequate for cleansing products, such shampoos body washes. One major deficiency that would not remain confined on top epidermis a high chance...