A5050132420- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Liver Disease and Transplantation
- Clinical Nutrition and Gastroenterology
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Poisoning and overdose treatments
- Cancer Immunotherapy and Biomarkers
- Economic and Financial Impacts of Cancer
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
Hadassah Medical Center
2017-2025
Hebrew University of Jerusalem
2020-2025
University of Chicago
2022-2025
Cancer Care Specialists of Illinois
2024
University Medical Center
2019-2023
Zero to Three
2022
Hadassah Academic College
2021
Advocate Lutheran General Hospital
2020
Northwestern University
1992-2005
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
1993-2005
PURPOSE Since the only three cases of granulocytic sarcoma among patients with acute myeloid leukemia (AML) seen at our institution during last 12 years were each associated 8;21 translocation [t(8;21)], we sought to determine if this association is specific and more frequent than previously recognized. PATIENTS AND METHODS We report AML t(8;21) who developed sarcomas, review world literature. RESULTS Between 1980 1992, 53 French-American-British (FAB) M2 identified institution. Eight (15%)...
Summary Background Namodenoson, an A3 adenosine receptor (A3AR) agonist, improved liver function/pathology in non‐alcoholic steatohepatitis (NASH) preclinical models. Aim To evaluate the efficacy and safety of namodenoson for treatment fatty disease (NAFLD) with or without NASH Methods This phase 2 study included 60 patients NAFLD (ALT ≥60 IU/L) who were randomised (1:1:1) to oral 12.5 mg b.d. (n = 21), 25 19), placebo 20) 12 weeks (total follow‐up: 16 weeks). The main endpoint involved...
PURPOSE To determine the response rate to 2-chlorodeoxyadenosine (2-CdA; cladribine) in patients with advanced indolent non-Hodgkin's lymphoma (NHL) who fail respond or progress after a standard chemotherapy drugs. PATIENTS AND METHODS Twenty-one were treated at least one cycle of 2-CdA 0.1 mg/kg/d by continuous infusion for 5 7 days. RESULTS The overall (complete [CR] and partial [PR]) was nine 21 (43%; 95% confidence interval, 22% 64%). Unmaintained durable responses (longest follow-up,...
Stroke and thromboembolic events occurring among patients taking direct oral anticoagulants (DOACs) have been associated with low concentrations of DOACs. Enzyme-inducing antiseizure medications (EI-ASMs) are enhanced cytochrome-P450-mediated metabolism P-glycoprotein-mediated transport.The aim this study was to evaluate the effect concomitant EI-ASM use on DOAC peak in treated clinical care.We performed a retrospective cohort DOACs for atrial fibrillation venous disease an academic general...
PURPOSE Cladribine (2-CdA), a purine analog resistant to adenosine deaminase, has significant activity in variety of lymphoproliferative diseases. This study was designed determine the efficacy 2-CdA patients with relapsed or refractory chronic lymphocytic leukemia (CLL). PATIENTS AND METHODS Twenty-six aged 40 88 years (median, 64) who either had after an initial response were conventional chemotherapy at least alkylating agent treated 0.1 mg/kg/d by continuous intravenous infusion for 5 7...
9109 Background: The MYLUNG (Molecularly Informed Lung Cancer Treatment in a Community Network) consortium pragmatic study aims to identify and overcome barriers timely appropriate biomarker testing patients (pts) with NSCLC. We previously reported retrospective real-world rates for 5 biomarkers from 2018-2020 metastatic pts. now report results the prospective observational phase, including additional pts both early advanced Methods: This was prospective, non-interventional cohort of newly...
PURPOSE To determine the role of computed tomography (CT) in patients with hairy cell leukemia (HCL), we report a series 43 prospectively evaluated for internal adenopathy by CT before and after treatment 2-chlorodeoxyadenosine (2-CdA). PATIENTS AND METHODS was performed on consecutive HCL 3 months single cycle 2-CdA. Twenty-four were previously diagnosed 19 newly diagnosed. Adenopathy considered bulky if greatest dimension any confluent mass between 5 10 cm massive greater than cm. RESULTS...
The aim of this study was to determine the long term outcome and toxicities after administration 2-chlorodeoxyadenosine (2-CdA) patients with previously treated, advanced, indolent non-Hodgkin's lymphoma (NHL).Twenty-two (median age, 55 years) relapsed or refractory low grade NHL disease duration, 2.8 were treated 2-CdA by continuous infusion at 0.1 mg/kg/day over 5 7 days every 28 days, for a maximum 6 cycles.The overall response rate 45%. Two (9%) achieved complete (CR), 8 (36%) partial...
A majority of acutely ill Crohn's disease [CD] patients who present to Emergency Department [ED] will undergo an abdominal CT rule out complications. We aimed generate a simple non-invasive scoring model predict the presence intra-abdominal abscess in CD ED.We performed retrospective case-control study at four Israeli hospitals from January 1, 2010 May 30, 2018. Inclusion criteria included with established diagnosis that had cross-sectional imaging performed. total 322 were included, and 81...