A5090328090- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Advanced Image and Video Retrieval Techniques
- Autonomous Vehicle Technology and Safety
- Image Retrieval and Classification Techniques
- Handwritten Text Recognition Techniques
- Educational Research and Pedagogy
- Asthma and respiratory diseases
- Video Surveillance and Tracking Methods
- Molecular Biology Techniques and Applications
- Robotics and Sensor-Based Localization
- Technology Adoption and User Behaviour
- Medical Image Segmentation Techniques
- Digital Economy and Work Transformation
- Educational Systems and Policies
- Phase Equilibria and Thermodynamics
- Gut microbiota and health
- Additive Manufacturing Materials and Processes
- Extracellular vesicles in disease
- Technology and Data Analysis
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Image and Object Detection Techniques
- Welding Techniques and Residual Stresses
- Plant-Microbe Interactions and Immunity
Myongji Hospital
2022-2025
Korea University
2000-2024
Kyung Hee University
2023-2024
Inha University
2023-2024
Korea Institute of Industrial Technology
2023-2024
Brigham and Women's Hospital
2022
Albany Medical Center Hospital
2022
Harvard University
2022
Seoul National University
2011-2021
Seoul National University Hospital
2015-2021
Despite recent advances in commercially optimized identification systems, bacterial remains a challenging task many routine microbiological laboratories, especially situations where taxonomically novel isolates are involved. The 16S rRNA gene has been used extensively for this when coupled with well-curated database, such as EzTaxon, containing sequences of type strains prokaryotic species validly published names. Although the EzTaxon database widely isolates, from uncultured prokaryotes...
Among available genome relatedness indices, average nucleotide identity (ANI) is one of the most robust measurements genomic between strains, and has great potential in taxonomy bacteria archaea as a substitute for labour-intensive DNA-DNA hybridization (DDH) technique. An ANI threshold range (95-96%) species demarcation had previously been suggested based on comparative investigation DDH values, albeit with rather limited datasets. Furthermore, its generality was not tested all lineages...
Species demarcation in Bacteria and Archaea is mainly based on overall genome relatedness, which serves a framework for modern microbiology. Current practice obtaining these measures between two strains shifting from experimentally determined similarity obtained by DNA-DNA hybridization (DDH) to genome-sequence-based similarity. Average nucleotide identity (ANI) simple algorithm that mimics DDH. Like DDH, ANI values sequences may be different each other when reciprocal calculations are...
EzEditor is a Java-based molecular sequence editor allowing manipulation of both DNA and protein alignments for phylogenetic analysis. It has multiple features optimized to connect initial computer-generated alignment subsequent analysis by providing manual editing with reference biological information specific the genes under consideration. provides various functionalities rRNA using secondary structure information. In addition, it supports simultaneous sequences their translated...
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For more than a decade, pan-genome analysis has been applied as an effective method for explaining the genetic contents variation of prokaryotic species. However, genomic characteristics and detailed structures gene pools have not fully clarified, because most studies used small number genomes. Here, we constructed pan-genomes seven species in order to elucidate variations >27,000 genomes belonging Streptococcus pneumoniae, Staphylococcus aureus subsp. aureus, Salmonella enterica enterica,...
Taxonomic identification is fundamental to all microbiology studies. Particularly in metagenomics, which identifies the composition of microorganisms using thousands sequences, its importance even greater. Identification inevitably affected by choice database. This study was conducted evaluate accuracy three widely used 16S databases—Greengenes, Silva, and EzBioCloud—and suggest basic guidelines for selecting reference databases. Using public mock community data, each database assign...
Background: Constipation is a common gastrointestinal disorder and often accompanied by alteration in the gut microbiota. Recently, several studies have disclosed its association with an increased risk of cardiovascular disease mortality general population. Despite high prevalence constipation, data on clinical impact constipation patients chronic kidney are limited. We aimed to explore using nationally representative cohort hemodialysis patients. Methods: This study used quality assessment...
Active research into vehicle detection and tracking using a vision sensor are done for driver assistance systems (DAS) - collision warning avoidance, enhancement, etc. The algorithm DAS requires robust feature extraction method regardless of the light road conditions an exact estimation position velocity distance from ego-vehicle. But most was carried out in day time with good lighting little so far night assumed no interference headlights other vehicles. This paper proposes new at any sonar...
A facile hydrothermal route has been developed for the synthesis of nearly spherical copper nanoparticles, nanocubes and ribbon-like network nanostructures. The as-prepared nanostructures were characterized by X-ray diffraction (XRD), photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission (TEM), high-resolution TEM (HRTEM), UV-vis spectrum analysis. These products fabricated in presence surfactant sodium dodecyl benzenesulfonate (SDBS) acting not only as...
We hypothesized that the pharmacodynamic (PD) characteristics of metformin would change with inhibition multidrug and toxin extrusion (MATE) transporter, which mediates renal elimination metformin. Twenty healthy male subjects received two doses (750/500 mg) metformin, without 50 mg pyrimethamine (a potent MATE inhibitor), 1 week washout in between each dose. The PD were assessed using oral glucose tolerance tests (OGTTs) before after Metformin concentrations plasma urine determined liquid...
Viruses have evolved sophisticated mechanisms to manipulate host cell processes and utilize intracellular organelles facilitate their replication. These complex interactions between viruses cellular allow them hijack the machinery impair homeostasis. Moreover, viral infection alters membrane’s structure composition induces vesicle formation trafficking of components. However, research focus has predominantly been on immune response elicited by viruses, often overlooking significant...
Abstract As a result of advances in sequencing technology, the role gut microbiota mechanism type-2 diabetes mellitus (T2DM) has been revealed. Studies showing wide distribution microbiome throughout human body, even blood, have motivated investigation dynamics across humans. Particularly, extracellular vesicles (EVs), lipid bilayer structures secreted from microbiota, recently come into spotlight because microbe-derived EVs affect glucose metabolism by inducing insulin resistance. Recently,...
A group of bacterial strains formerly known as CDC M-5 are opportunistic pathogens to humans. In 1993, a name, Neisseria weaveri, was proposed by two independent studies harbor strains, namely N. weaveri Holmes et al. 1993 and Andersen with different 'type' strains. However, no study has been conducted on the relatedness although close relationship taxa long accepted unofficially. Formally, status name is illegitimate because it later homonym al., 1993; but strain still validly published....
A Gram-stain-negative, rod-shaped, pale yellow, aerobic bacterial strain, JC2902(T), was isolated from a sediment sample of Ungok Lake in Gochang, Republic Korea. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain JC2902(T) belongs to the genus Flavobacterium and forms distinct phyletic line within clade containing four recognized species Flavobacterium. The genomic relatedness between closely related strains calculated using average nucleotide identity values whole...
A Gram-stain negative, rod-shaped, non-spore-forming, obligate aerobic bacterial strain, JC2949(T), was isolated from grassland soil in Gwanak Mountain, Seoul, Republic of Korea. Phylogenetic analysis, based on 16S rRNA sequences, indicated that strain JC2949(T) belongs to the genus Burkholderia, showing highest sequence similarities with Burkholderia grimmiae R27(T) (98.8 %), cordobensis LMG 27620(T) (98.6 jiangsuensis MP-1T(T) zhejiangensis OP-1(T) (98.5 humi 22934(T) (97.5 terrestris...
We aimed to investigate the effect of internet-based and in-person cognitive interventions on cognition, mood, activities daily living (ADL) patients with mild moderate Alzheimer's disease (AD) examine whether intervention is as effective intervention. recruited 52 probable AD, whom 42 completed trial. randomly divided participants into control groups at a 1:1 ratio statistically compared neuropsychological test results two groups. In addition, in group were assigned 4 weeks or intervention,...