A5001379147- Biomarkers in Disease Mechanisms
- Immune responses and vaccinations
- Immune cells in cancer
- Inflammation biomarkers and pathways
- COVID-19 Impact on Reproduction
- Healthcare Systems and Public Health
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Calcium signaling and nucleotide metabolism
- Neonatal Respiratory Health Research
- Vaccine Coverage and Hesitancy
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Inflammatory Biomarkers in Disease Prognosis
- Intensive Care Unit Cognitive Disorders
- Adenosine and Purinergic Signaling
- Macrophage Migration Inhibitory Factor
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
University of Lausanne
2017-2023
University Hospital of Lausanne
2023
Abstract Background The innate immune system recalls a challenge to adapt secondary challenge, phenomenon called trained immunity. Training involves cellular metabolic, epigenetic and functional reprogramming, but how broadly immunity protects from infections is unknown. For the first time, we addressed whether provides protection in large panel of preclinical models infections. Methods Mice were subjected systemic infections, peritonitis, enteritis, pneumonia induced by Staphylococcus...
Sirtuin 2 (SIRT2) is one of the seven members family NAD+-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides mainly in cytoplasm regulates cytoskeleton dynamics, cell cycle metabolic pathways. As such, has been implicated pathogenesis neurodegenerative, metabolic, oncologic chronic inflammatory disorders. This motivated development SIRT2-directed therapies for...
Constitutively expressed by innate immune cells, the cytokine macrophage migration inhibitory factor (MIF) initiates host responses and drives pathogenic in infectious, inflammatory, autoimmune diseases. Dendritic cells (DCs) express high levels of MIF, but role MIF DC function remains poorly characterized. As is critical for surveillance, we investigated whether promoted DCs. In classical transwell experiments, MIF−/− bone marrow-derived DCs (BMDCs) or MIF+/+ BMDCs treated with ISO-1, an...
Trained immunity refers to the ability of innate immune system exposed a first challenge provide an enhanced response secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection confers protection against broad-spectrum lethal bacterial infections. Whether this persists over time is unknown. To tackle question, we analyzed status and Listeria monocytogenes (L. monocytogenes) mice trained 9 weeks analysis. The induction increased...
Myeloid-derived suppressor cells (MDSCs) are immature myeloid with immunosuppressive functions sub-classified into monocytic and polymorphonuclear MDSCs (M-MDSCs PMN-MDSCs). Clinical studies reported increased levels of that were associated poor outcome in sepsis patients. Since patients exhibit signs inflammation immunosuppression, may provide benefit by dampening deleterious some To test this hypothesis, we measured critically ill pneumonia multi-organ dysfunctions a high likelihood...
Sirtuin 5 (SIRT5) is a member of the family NAD+-dependent lysine/histone deacetylases. SIRT5 resides mainly in mitochondria where it catalyses deacetylation, demalonylation, desuccinylation and deglutarylation lysine to regulate metabolic oxidative stress response pathways. Pharmacologic inhibitors are under development for oncologic conditions, but nothing known about impact on antimicrobial innate immune defenses. Using knockout mice, we show that deficiency does not affect cell...
Streptococcus pneumoniae is a major pathogen in children, elderly subjects, and immunodeficient patients. Pentraxin 3 (PTX3) fluid-phase pattern recognition molecule (PRM) involved resistance to selected microbial agents regulation of inflammation. The present study was designed assess the role PTX3 invasive pneumococcal infection. In murine model infection, strongly induced non-hematopoietic (particularly, endothelial) cells. IL-1β/MyD88 axis played Ptx3 gene expression. −/− mice presented...
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS R848. show that COVID-19 induces a rapid, transient upregulation myeloid-derived suppressor cells (MDSCs) accompanied sustained (up 3 months) hyporesponsiveness dendritic monocytes. Blood MDSCs may represent biomarkers targets for intervention strategies in patients.
Abstract Streptococcus pneumoniae is a major pathogen in children, elderly subjects and immunodeficient patients. PTX3 fluid phase pattern recognition molecule (PRM) involved resistance to selected microbial agents regulation of inflammation. The present study was designed assess the role invasive pneumococcal infection. In murine model infection, strongly induced non-hematopoietic (particularly, endothelial) cells. IL-1β/MyD88 axis played Ptx3 gene expression. -/- mice were more susceptible...