A5067274607- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Lipid Membrane Structure and Behavior
- Cardiovascular Syncope and Autonomic Disorders
- Cancer Immunotherapy and Biomarkers
- Consumer Behavior in Brand Consumption and Identification
- Inflammation biomarkers and pathways
- Behavioral Health and Interventions
- vaccines and immunoinformatics approaches
- Hemophilia Treatment and Research
- Neurological and metabolic disorders
- Thermal Regulation in Medicine
- Bladder and Urothelial Cancer Treatments
- Phagocytosis and Immune Regulation
- Sphingolipid Metabolism and Signaling
- Neutropenia and Cancer Infections
- Cardiac Imaging and Diagnostics
- Genetics and Physical Performance
- Renal function and acid-base balance
- Blood Coagulation and Thrombosis Mechanisms
- Erythrocyte Function and Pathophysiology
- Pain Management and Treatment
- Intensive Care Unit Cognitive Disorders
University of Lausanne
2003-2022
Klinički Bolnički Centar Rijeka
2021
Ludwig Cancer Research
2003-2018
Data Harbor (United States)
2015
Ludwig-Maximilians-Universität München
2000
University of Tübingen
1991
We conducted a pilot clinical trial testing personalized vaccine generated by autologous dendritic cells (DCs) pulsed with oxidized whole-tumor cell lysate (OCDC), which was injected intranodally in platinum-treated, immunotherapy-naïve, recurrent ovarian cancer patients. OCDC administered alone (cohort 1, n = 5), combination bevacizumab 2, 10), or plus low-dose intravenous cyclophosphamide 3, 10) until disease progression exhaustion. A total of 392 doses were without serious adverse events....
Through a rational design approach, we generated panel of HLA-A*0201/NY-ESO-1(157-165)-specific T cell receptors (TCR) with increasing affinities up to 150-fold from the wild-type TCR. Using these TCR variants which extend just beyond natural affinity range, along an extreme supraphysiologic one having 1400-fold enhanced affinity, and low-binding one, sought determine effect binding properties cognate peptide concentration on CD8(+) responsiveness. Major histocompatibility complexes (MHC)...
PurposeAlthough localized prostate cancer (PCa) is multifocal, the dominant intraprostatic nodule (DIN) responsible for disease progression after radiation therapy. PCa expresses antigens that could be recognized by immune system. We therefore hypothesized stereotactic dose escalation to DIN safe, may increase local control, and initiate tumor-specific responses.Patients MethodsPatients with were treated extreme hypofractionated doses of 36.25 Gy in 5 fractions whole while simultaneously...
Myeloid-derived suppressor cells (MDSCs) are immature myeloid with immunosuppressive functions sub-classified into monocytic and polymorphonuclear MDSCs (M-MDSCs PMN-MDSCs). Clinical studies reported increased levels of that were associated poor outcome in sepsis patients. Since patients exhibit signs inflammation immunosuppression, may provide benefit by dampening deleterious some To test this hypothesis, we measured critically ill pneumonia multi-organ dysfunctions a high likelihood...
Background: Inflammation plays an important role in the initiation of atrial fibrillation (AF) and development fibrosis following pulmonary vein isolation (PVI). We aimed to investigate whether early post-PVI levels C-reactive protein (CRP), white blood cells, tumour necrosis factor alpha (TNF-α) transforming growth beta 1 (TGF-ß1) are associated with long-term arrhythmia recurrence. Methods: This prospective observational study included 48 patients paroxysmal AF undergoing PVI. Peripheral...
Although their contribution remains unclear, lipids may facilitate noncanonical routes of protein internalization into cells such as those used by cell-penetrating proteins. We show that C inhibitor (PCI), a serine protease (serpin), rapidly transverses the plasma membrane, which persists at low temperatures and enables its nuclear targeting in vitro vivo. Cell membrane translocation PCI necessarily requires phosphatidylethanolamine (PE). In parallel, acts lipid transferase for PE. The...
Abstract In HLA-A2 individuals, the CD8 T cell response against differentiation Ag Melan-A is mainly directed toward peptide Melan-A26–35. The murine Melan-A24–33 sequence encodes a that identical with human Melan-A26–35 decamer, except for Thr-to-Ile substitution at penultimate position. Here, we show naturally processed and presented by molecules. Based on these findings, compared to immunizing transgenic mice. Even though magnitude of CTL elicited was lower than one peptide, both...
The effects of exogenous cytokines on the generation alloindifferent, MHC-unrestricted suppressive activity early in mixed lymphocyte culture interactions have been investigated. Interleukin 4 strongly blocked suppression, whereas IL-1, IL-2, and IL-6 enhanced it to some extent. Tumor necrosis factor-α, interferons-α -γ, granulocyte/macrophage colonystimulating factor, granulocyte CSF, IL-3 IL-5, a number combinations these factors were without effect this system. Insofar as alloindifferent...
Meeting abstracts Although promising, the combination of long synthetic peptides and CpG-B oligodeoxynucleotides has not yet been tested as cancer vaccine. In this Phase I trial, 19 patients received a mean 8 (range 1-12) monthly vaccines s.c. composed NY-ESO79-108 peptide
Pojam trombofilija podrazumijeva nasljedne i/ili stečene poremećaje sustava zgrušavanja krvi koji predisponiraju razvoj tromboze. Nasljedna obuhvaća stanja u kojima naslijeđene genetske mutacije dovode do abnormalne količine ili funkcije proteina uključenih sustav koagulacije, što za posljedicu može imati povećanu sklonost venskim i, znatno rjeđe, arterijskim trombozama. Nedvojbeno definirana nasljedna trombofilna nedostatak su antitrombina, C i S te pojava faktora V Leiden protrombinskih...