A5102737479- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Bone Tissue Engineering Materials
- Bone health and treatments
- Immune Response and Inflammation
- Titanium Alloys Microstructure and Properties
- Osteoarthritis Treatment and Mechanisms
- Network Security and Intrusion Detection
- Orthopaedic implants and arthroplasty
- NF-κB Signaling Pathways
- Network Packet Processing and Optimization
- Access Control and Trust
- Cleft Lip and Palate Research
- Cytokine Signaling Pathways and Interactions
- Developmental Biology and Gene Regulation
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Software-Defined Networks and 5G
- S100 Proteins and Annexins
- Bone and Dental Protein Studies
- Craniofacial Disorders and Treatments
- Congenital limb and hand anomalies
- Nuclear Receptors and Signaling
- Cell Adhesion Molecules Research
- Congenital heart defects research
Tohoku University
2012-2025
Fujitsu (Japan)
2010-2020
Showa University
2010-2019
Western University
2017
Niigata University
2012
University of Fukui
2010
Various retinoid X receptor (RXR) agonists have recently been developed, and some of them shown anti-tumor effects both in vivo vitro. However, there has no report showing the RXR on Cushing's disease, which is caused by excessive ACTH secretion a corticotroph tumor pituitary gland. Therefore, we examined synthetic pan-agonists HX630 PA024 proliferation, apoptosis, secretion, pro-opiomelanocortin (Pomc) gene expression murine AtT20 cells. We demonstrated that induced apoptosis...
Cdc42 is a widely expressed protein that belongs to the family of Rho GTPases and controls broad variety signal transduction pathways in cell types. To investigate physiological functions during cartilage development, we generated chondrocyte-specific inactivated mutant mice (Cdc42(fl/fl); Col2-Cre). The gross morphology neonates showed shorter limbs body as compared with control (Cdc42(fl/fl)). Skeletal preparations stained alcian blue alizarin red also revealed long bone length mutants...
The processing suitability as a material for rice crackers was characterized in the present study, based on physicochemical measurements and sensory testing of high-quality premium rice, low-amylose Japonica-Indica hybrid red cultivar samples. Puffed were prepared relationship between properties grains quality resulting products investigated. It possible to estimate physical cracker by using multiple-regression analysis chemical components, pasting constituent rice. A formula estimating...
Nephronectin (Npnt), also called POEM, is an extracellular matrix protein considered to play critical roles as adhesion molecule in the development and functions of various tissues, such kidneys, liver, bones. In present study, we examined molecular mechanism Npnt gene expression found that oncostatin M (OSM) strongly inhibited mRNA MC3T3‐E1 cells from a mouse osteoblastic cell line. OSM induced decrease both time‐ dose‐dependent manners via JAK/STAT MAPK pathways. addition, OSM‐induced...
Interferon regulatory factor 8 (Irf8) is a transcription that negatively regulates osteoclast differentiation and Irf8 global knockout (Irf8 −/−) mice have been shown to reduced bone volume resulting from increased numbers. However, detailed analysis of the functions in precursors with monocyte/macrophage linage difficult, because population properties hematopoietic cells −/− are severely altered. Therefore, clearly elucidate during osteoclastogenesis, we established myeloid cell-specific...
POEM, also called nephronectin, is an extracellular matrix protein that considered to play a critical role as adhesion molecule in the development and functioning of various tissues, such kidneys bones. In present study, we examined molecular mechanism POEM gene expression, found transforming growth factor‐β (TGF‐β) strongly inhibited expression mouse osteoblastic cell line, MC3T3‐E1. TGF‐β‐induced decrease occurred both time‐ dose‐dependent manners through activation TGF‐β receptor I...
Bone morphogenetic proteins (BMPs) regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage bone formation, cranial limb development. Among them, BMP-2, one the most potent osteogenic signaling molecules, stimulates while it inhibits myogenic differentiation in C2C12 cells. To evaluate genes involved BMP-2-induced we performed cDNA microarray analyses to compare BMP-2-treated -untreated We focused on Alx3 (aristaless-like homeobox 3)...
Monocarboxylate transporter-1 (MCT-1) is a transmembrane transporter for monocarboxylates including lactate and pyruvate. Silencing Mct1 by its small interfering RNA (siRNA) suppressed the expression of marker genes osteoblast differentiation, namely, Tnap, Runx2, Sp7, induced BMP-2 in mouse myoblastic C2C12 cells. siRNA also alkaline phosphatase activity, as well expressions Tnap Bglap mRNAs primary osteoblasts. On other hand, did not have effects on Smad1/5 or ERK/JNK pathways...
Craniofacial deformities with multifactorial etiologies, such as cleft palate and facial dysmorphism, represent some of the most frequent congenital birth defects seen in humans. Their pathogeneses are often related to cranial neural crest (CNC) cells. During CNC cell migration, changes shape formation, well maintenance subcellular structures, filopodia lamellipodia, dependent on complex functions Rho family small GTPases, which regulators actin cytoskeletal organization. Cdc42, a member is...
Aldosterone synthase is the key rate‐limiting enzyme in adrenal aldosterone production, and induction of its gene ( CYP 11B2 ) results progression hypertension. As hypertension a frequent complication among patients with diabetes, we set out to elucidate link between diabetes mellitus We examined effects high glucose on expression production using human H295R cells stable cell line expressing 5′‐flanking region/luciferase cDNA chimeric construct. d ‐glucose ‐glu), but not enantiomer l...
The effects of retinoids on adrenal aldosterone synthase gene (CYP11B2) expression and secretion are still unknown. We therefore examined the nuclear retinoid X receptor (RXR) pan-agonist PA024 CYP11B2 expression, blood pressure, to elucidate its potential as a novel anti-hypertensive drug. demonstrated that significantly suppressed angiotensin II (Ang II)-induced mRNA promoter activity in human adrenocortical H295R cells. Human functional analyses using deletion point mutants indicated...