A5101810963- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Acute Kidney Injury Research
- Pain Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Memory and Neural Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Intergenerational Family Dynamics and Caregiving
- Dialysis and Renal Disease Management
- Pain Management and Placebo Effect
- Respiratory Support and Mechanisms
- Platelet Disorders and Treatments
- Neonatal and fetal brain pathology
- Demographic Trends and Gender Preferences
- Neural dynamics and brain function
- Korean Urban and Social Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiovascular Conditions and Treatments
- Infant Nutrition and Health
- RNA regulation and disease
- Preterm Birth and Chorioamnionitis
- Immunotherapy and Immune Responses
Celltrion (South Korea)
2025
National Cancer Center
2025
Kyung Hee University Hospital at Gangdong
2015-2024
Soonchunhyang University
2023
Kyung Hee University
2019-2022
Seoul National University
2017-2022
Neuroelectronics Research Flanders
2019-2022
Hanyang University
2021
Asan Medical Center
2017-2020
University of Ulsan
2017-2020
Oxidative stress and mitochondrial dysfunction have been believed to play an important role in the pathogenesis of aging neurodegenerative diseases, including Parkinson's disease (PD). The excess reactive oxygen species (ROS) increases with age causes a redox imbalance, which contributes neurotoxicity PD. Accumulating evidence suggests that NADPH oxidase (NOX)-derived ROS, especially NOX4, belong NOX family is one major isoforms expressed central nervous system (CNS), associated progression...
In Korea, the birth rate is declining at an alarming pace. This study aimed to investigate changes and trends in population count, number of births, past future.Data regarding total crude rate, fertility were collected from "Statistics Korea Census" national statistical portal, census report, Statistics Korea's "2020 Population Trend Survey for 1981-2020, provisional results death statistics." We used Organisation Economic Co-operation Development 2019 Family Database TFR. To develop a...
Here, we evaluated the safety and immunogenicity of hepatitis B virus (HBV) DNA vaccine, HB-110, in mice Korean patients with chronic (CHB) undergoing adefovir dipivoxil (ADV) treatment.For animal study, (BALB/c or HBV transgenic) were immunized mHB-110, T-cell antibody responses evaluated. For clinical 27 randomly received either ADV alone combination HB-110. Liver function tests, serum levels presence HBeAg/anti-HBe analysed. estimated by ELISPOT FACS analysis.mHB-110 induced higher than...
Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, these disturbances in turn affect aversive perception of pain. However, underlying mechanisms are largely unknown. We hypothesized that alteration metabotropic glutamate receptor 5 (mGluR5) brain region underlies a comorbidity states. scanned neuropathic model rats using positron emission tomography (PET) technique an mGluR5-selective radiotracer [11C] ABP688 found various regions higher or...
Abstract Purpose: We found that most ATP production in cancer cells depends on fatty acid oxidation (FAO). Most chemotherapeutic reagents including FOLFIRINOX regimen targeted anabolic metabolism of such as DNA replication. All synthesis mechanisms require for chemical reactions. Therefore, we proposed blocking FAO together with chemotherapeutics may synergize anti-cancer effect by suppressing growth metabolism. Experimental Design: To block FAO, CAC (carnitine-acylcarnitine carrier, gene:...
Abstract Background Superior efficacy of subcutaneous infliximab (CT-P13 SC) over placebo for maintenance therapy in patients with Crohn’s disease (CD) and ulcerative colitis (UC) was demonstrated the randomized LIBERTY-CD LIBERTY-UC studies. The current post hoc analysis compared outcomes CT-P13 SC by baseline immunosuppressant use. Methods Patients moderately to severely active CD or UC arm 54-week LIBERTY trials at week 10 who were treated open-label extension (weeks 56–102) included....
Pulmonary surfactants, a complex assembly of phospholipids and surfactant proteins such as SP-B SP-C, are critical for maintaining respiratory system functionality by lowering surface tension (ST) preventing alveolar collapse. Our study introduced five synthetic peptides one SP-C peptide, leading to the synthesis CHAsurf candidates (CHAsurf-1 CHAsurf-5) evaluation. We utilized modified Wilhelmy balance test assess properties measuring spreading rate, adsorption, ST-area diagrams...
Respiratory distress syndrome (RDS) is a disease that commonly affects premature infants whose lungs are not fully developed. RDS results from lack of surfactant in the lungs. The more infant is, greater likelihood having RDS. However, even though all have RDS, preemptive treatment with artificial pulmonary administered most cases.We aimed to develop an intelligence model predict avoid unnecessary treatment.In this study, 13,087 very low birth weight who were newborns weighing less than 1500...
Due to increases in the number of infants born with younger gestational age (GA) and lower birth weight, incidence neonatal sepsis is increasing.We investigated changes prevalence bacterial pathogens, their antimicrobial susceptibility, sepsis-related mortality during 20 years at a intensive care unit.The study period was divided into two 10-year phases (1998-2007 vs. 2008-2017). Medical records were reviewed gather data on demographics, causative microbial multidrug-resistant organisms,...
Chronic placental inflammation (CPI) has been implicated in the pathogenesis of diseases premature infants, whereas retinopathy prematurity (ROP) is a major complication primarily affecting preterm and very low-birth-weight (VLBW) infants. This study aims to investigate association between CPI ROP VLBW infants.We performed retrospective review clinical records infants born 2013 2016. Placental pathology findings including cases were analyzed using logistic regression infants' morbidities...
This study examined the outcomes of children with chronic immune thrombocytopenia (ITP). We retrospectively analyzed medical records all patients diagnosed ITP from January 1992 to December 2011 at our institution. A total 128 (64%) satisfied criteria for newly ITP, 31 (15%) persistent and 41 (21%) ITP. The median age diagnosis was 4.5 years (range, 1 month 18 years). platelet count 32×10⁹/L. comparison initial treatment data 2001 those 2000 showed that number bone marrow examinations...
Purpose The importance of the neurodevelopmental outcomes very-low-birth-weight (VLBW) infants has been emphasized as their mortality rate markedly improved. This study aimed to assess validity Korean Developmental Screening Test (K-DST), a developmental screening tool approved by Society Pediatrics, for timely diagnosis delay in VLBW infants. Methods Subjects included enrolled Neonatal Network database between January 2012 and December 2014. collected data were analyzed sensitivity,...
<b><i>Background:</i></b> Management of newborn infants with congenital anomalies is challenging and requires a multidisciplinary approach. The prevalence in very-low-birth-weight (VLBWIs; birth weight &#x3c;1,500 g) has been rarely reported. <b><i>Objectives:</i></b> aim this study was to investigate the epidemiology VLBWIs association early mortality major morbidities. <b><i>Study Design:</i></b> A prospective...
This study aimed to provide morbidity and mortality information on very low birth weight (VLBW) infants with congenital heart disease (CHD-VLBWs).The used a 10-year cohort of VLBW from single institution. CHD was classified according International Classification Diseases, Version 9, Clinical Modification. Mortality neonatal outcomes were assessed by comparing the CHD-VLBWs gestational age- weight-matched controls.The prevalence 7.5% (79/1,050), mean age 31.1±3.2 weeks, 1,126.2±268.3 g; 50.6%...
This review examines the critical issues of declining total fertility rates (TFRs) and aging populations in East Asia with special focus on South Korea. It provides a comprehensive analysis TFR trends, demographics, policy responses these nations to low-fertility crisis. study highlights intricate tapestry factors contributing demographic shifts, including economic, social, cultural influences. also effectiveness various prenatal policies implemented across countries, offering insight into...
Abstract Background Peritoneal dialysis (PD) has been used occasionally in extremely-low-birth-weight (ELBW) infants with acute kidney injury (AKI). This study aimed to evaluate the clinical characteristics and outcomes of ELBW AKI treated PD. Methods In this retrospective cohort study, medical records AKI, who underwent PD from January 2008 February 2018, were reviewed. A catheter (7.5–9.0 Fr) or central venous (4 was for peritoneal access. Treatment solutions (2.5 4.25%) started at 10...
Surgical resection of large symptomatic congenital pulmonary airway malformation (CPAM) in newborns has high risks mortality and postoperative morbidity. This study aimed to report the clinical outcomes who underwent percutaneous transthoracic catheter drainage (PTCD) CPAM before surgical resection.This was a retrospective, descriptive based on review medical records newborn infants required at single tertiary hospital from 2001 2017. The were compared between patients following PTCD (PTCD...
Objective: To review trends in treatment outcomes, to determine risk factors for mortality, and present a cut-off values of observed/expected lung head ratio (O/E LHR) predicting mortality infants with congenital diaphragmatic hernia (CDH). Methods: A retrospective study CDH treated the neonatal intensive care unit at tertiary medical center over 27 years (1989 2016) was done. We analyzed associated based on significant best value O/E LHR sought. Results: total 264 patients were included...
The aim of our study was to measure the basal serum cortisol concentration immediately after birth and determine its association with perinatal factors clinical outcomes in very low weight (VLBW) infants.Basal level obtained within one hour inborn VLBW infants. between analyzed by comparing groups high versus levels.In total, 80 infants were included. median 167 nmol/L an interquartile range 98-298 nmol/L. positively correlated elapsed time from last betamethasone dose. Low associated...