A5100365949- Dermatologic Treatments and Research
- Vascular Malformations and Hemangiomas
- Skin Protection and Aging
- Retinal Development and Disorders
- Advanced biosensing and bioanalysis techniques
- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Vascular Tumors and Angiosarcomas
- Cancer Risks and Factors
- Laser Applications in Dentistry and Medicine
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Ear and Head Tumors
- Toxoplasma gondii Research Studies
- Cell Adhesion Molecules Research
- Treatment of Major Depression
- Vascular Malformations Diagnosis and Treatment
- Polysaccharides and Plant Cell Walls
- Eosinophilic Disorders and Syndromes
- Protein Degradation and Inhibitors
- Coffee research and impacts
- Corneal surgery and disorders
- Autophagy in Disease and Therapy
- Gastric Cancer Management and Outcomes
- Corneal Surgery and Treatments
Central South University
2024-2025
Sichuan University
2019-2025
West China Hospital of Sichuan University
2019-2025
Xiangya Hospital Central South University
2025
DePaul University
2024
Hospital Israelita Albert Einstein
2024
Universidad Nacional Autónoma de México
2024
Stanford University
2024
University of Alberta
2024
University of Lübeck
2024
Mutations in the PRPF8 gene frequently result retinitis pigmentosa (RP), an autosomal dominant inherited retinal disease that can lead to nyctalopia and progressive vision loss. Currently, no effective treatment is available. In this study, we used CRISPR/Cas9 technology introduce a heterozygous point mutation inthe of normal induced pluripotent stem cell (iPSC) line. This mirrors found previously reportedRP patient-derived iPSC line (CSUASOi006-A) from our group. Establishing...
Abstract Acne vulgaris is a prevalent cutaneous disease characterized by multifactorial pathogenic process including hyperseborrhea, inflammation, over‐keratinization of follicular keratinocytes and Propionibacterium acnes ( P ) overgrowth. Salicylic acid SA ), beta‐hydroxy acid, frequently used in the treatment acne. has been found to decrease skin lipids possess anti‐inflammatory properties. However, few studies have elucidated mechanisms pathways involved such In this study, we initially...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe potentially lethal adverse drug reaction. Its clinical complexity heterogeneity pose challenges for diagnosis management. We retrospectively reviewed the medical records of patients DRESS who were admitted to our hospital between 2013 2022. Data on demographics, culprit drugs, manifestations, laboratory findings, treatments collected. Fifty-one included in final analysis, 16 probable 35 definite cases. The most common...
Spherical culture could promote the plasticity and stemness of human corneal stromal cells (hCSCs). Here, we introduce a novel three-dimensional (3D) cell system based on polydimethylsiloxane (PDMS) microwell platform composed many V-bottom microcavities to generate spheroids stemness. We isolated hCSCs from SMILE-derived lenticules maintained their physiological phenotype by culturing them in medium supplemented with extract (hCSE). Utilizing PDMS fabricated through 3D printing technology,...
Background Papillary renal neoplasm with reverse polarity (PRNRP) is a relatively rare subtype of papillary cell carcinoma (PRCC) and considered to be tumor low malignant potential. Membranous nephropathy (MN) frequently associated tumors but rarely accompanies carcinoma. Synchronous membranous has not been reported in the current study. (We searched PubMed, Web Science databases, Embase, Medline English language from 1970 October 2024. The keywords used were “papillary polarity” “membranous...
Cannabidiol (CBD) has emerged as a phytocannabinoid with various beneficial effects for the skin, including anti-photoaging effects, but its mechanisms of action are not fully elucidated. The study assessed CBD's photoprotective against acute ultraviolet B (UVB)-induced damage in HaCaT human keratinocyte cells and murine skin tissue. CBD (8 μM) alleviated UVB-induced cytotoxicity, apoptosis, G2/M cell cycle arrest cells. contents γH2AX cyclobutane pyrimidine dimers were decreased after...
Port-wine stains are defined as congenital benign vascular lesions. The treatment of port-wine remains a challenge, worldwide. This study aimed to analyze the histological characteristics in different types and provide guidance for clinical decision-making.Biopsies were from hospital 2015 2021. H&E staining, Immunofluorescence Masson's trichrome staining Weigert performed on tissues.A total 35 patients included four distinct types, namely red (11 cases), purple (seven hypertrophic (nine...
Hematoporphyrin monomethyl ether (HMME) is a newly authorized photosensitizer for the treatment of port-wine stain (PWS) in China. However, no research on its efficacy treating PWS lesions Sturge-Weber syndrome (SWS) has been made. To assess and safety HMME-photodynamic therapy (PDT) SWS simple large segmental facial PWS. Medical records patients with were reviewed. Efficacy was evaluated according to color blanching graded as excellent (≥75%), good (50%-74%), fair (25%-49%), poor (≤24%)....
As one of the most obvious signs aging, wrinkles have long been concern many people and continue to be a major topic in dermal-cosmetic industry. Accordingly, there is need develop products with good efficacy safety profile. The Zanthoxylum bungeanum maxim (ZBM) extract natural food which may possess property toxin-like botulinum. To evaluate formulation that contains 2% ZBM pericarp treatment wrinkles. Twenty females aged 35-60 years old were enrolled this randomized, vehicle-controlled,...
In addition to invasive breast cancer, mammography screening often detects preinvasive ductal carcinoma in situ (DCIS) lesions. The natural progression of DCIS is largely unknown, leading uncertainty regarding treatment. history cancer has been studied using data. modeling more complicated because lesions might progress clinical DCIS, preclinical or may also regress a state undetectable by screening. We have here developed Markov model for progression, building on the established model.We...