A5018141663- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Inflammatory Myopathies and Dermatomyositis
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Genital Health and Disease
- Autoimmune and Inflammatory Disorders
- interferon and immune responses
- Autoimmune Bullous Skin Diseases
- Dermatologic Treatments and Research
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- COVID-19 and healthcare impacts
- HIV/AIDS drug development and treatment
- Cutaneous lymphoproliferative disorders research
- Hair Growth and Disorders
- Immunodeficiency and Autoimmune Disorders
- Cancer and Skin Lesions
- Craniofacial Disorders and Treatments
- Inflammatory Bowel Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dupuytren's Contracture and Treatments
- Viral Infections and Vectors
- Social Media in Health Education
University of Pennsylvania
2016-2025
Children's Hospital of Philadelphia
2023-2025
Brigham and Women's Hospital
2023-2024
Harvard University
2023
New York University
2020-2022
NYU Langone Health
2022
Memorial Sloan Kettering Cancer Center
2016-2018
Columbia University
2018
Cornell University
2016
Rockefeller University
2015
Identification of full-length transmitted HIV-1 genomes could be instrumental in pathogenesis, microbicide, and vaccine research by enabling the direct analysis those viruses actually responsible for productive clinical infection. We show 12 acutely infected subjects (9 clade B 3 C) that complete transmitted/founder can inferred single genome amplification sequencing plasma virion RNA. This allowed molecular cloning biological a comprehensive genome-wide assessment genetic imprint left on...
The nucleotide sequences of the large open reading frame (ORF) from segment A three European strains infectious bursal disease virus (IBDV) have been determined using cDNA clones. This ORF 3036 nucleotides encodes virion proteins as a polyprotein in following order: VP2, VP4, VP3. compared to each other and published sequence an Australian strain. four are closely related, greatest difference between two being 7.7% at level 2.7% amino acid level. Comparisons show that there is tight cluster...
Abstract African apes harbour at least six Plasmodium species of the subgenus Laverania , one which gave rise to human falciparum . Here we use a selective amplification strategy sequence genome chimpanzee parasites classified as reichenowi and gaboni based on subgenomic fragments. Genome-wide analyses show that these indeed represent distinct species, with no evidence cross-species mating. Both P. are 10-fold more diverse than indicating very recent origin parasite. We also find remarkable...
<h3>Importance</h3> To date, no study has characterized the mucocutaneous features seen in hospitalized children with multisystem inflammatory syndrome (MIS-C) or temporal association of these findings onset systemic symptoms. <h3>Objective</h3> describe MIS-C during height coronavirus disease 2019 (COVID-19) pandemic New York City 2020. <h3>Design, Setting, and Participants</h3> A retrospective case series was conducted 35 admitted to 2 hospitals between April 1 July 14, 2020, who met...
ABSTRACT This single‐institution retrospective cohort study evaluates the risk of thromboembolic events (TE) in patients with juvenile dermatomyositis (JDM) treated intravenous immunoglobulin (IVIg). We found no difference occurrence TE JDM IVIg as compared to those without exposure; both cohorts had TEs. Patients matched levels other clotting factors, such periods limited mobility and hormonal contraceptive use. research supports growing body evidence adult DM population demonstrating...
ABSTRACT Background Cutaneous Crohn's disease (CCD) is a granulomatous condition of the skin discontiguous from gastrointestinal tract. rarely correlates with intestinal and often requires separate treatment. While use interleukin‐12/23 (IL‐12/IL‐23) interleukin‐23 (IL‐23) inhibitors FDA‐approved for (CD), there limited data CCD. We retrospectively reviewed clinical features 24 cases CCD treated risankizumab as monotherapy, ustekinumab or in combination vedolizumab seven academic...
Importance Metastatic cutaneous Crohn disease (MCD) is a rare condition for which there are currently no published diagnostic criteria. Formal MCD criteria will expand clinical care and research by enabling future code validation, crystallizing more uniform entity the purposes of translational research, allowing development formalized outcome measures aimed at treatment response. Objective To define set diagnosis MCD. Evidence Review In this consensus statement, panel experts on related...
Penile intraepithelial neoplasia (PIN) is a rare disease that can be associated with great morbidity and mortality. Historically, the term PIN has been used to refer 3 premalignant penile lesions: Bowen (BD), erythroplasia of Queyrat (EQ), Bowenoid papulosis (BP). Although these clinical variants share similar histopathologic features squamous cell carcinoma in situ—namely, transepidermal keratinocyte atypia, numerous mitotic figures, nuclear crowding—they vary their presentation.