A5013032444- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
- Cerebrovascular and Carotid Artery Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Atherosclerosis and Cardiovascular Diseases
- Frailty in Older Adults
- Elasticity and Material Modeling
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Mechanical Circulatory Support Devices
- Adipokines, Inflammation, and Metabolic Diseases
- Lattice Boltzmann Simulation Studies
University of Sheffield
2016-2025
Insigneo
2016-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2016-2025
The University of Texas Medical Branch at Galveston
2024-2025
University Hospitals Bristol NHS Foundation Trust
2023-2024
Northern General Hospital
2013-2023
Eindhoven University of Technology
2022
Daresbury Laboratory
2021
Sheffield Hallam University
2021
National Health Service
2017-2021
AimsAcute coronary syndromes (ACSs) are driven by inflammation within plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation. We hypothesized that if IL-1 is a driving influence non-ST elevation (NSTE-ACS), inhibition would reduce inflammatory response at time ACS.
Background —Cytokine gene variations are contributory factors in inflammatory pathology. Allele frequencies of interleukin (IL)-1 cluster genes [IL-1A(-889), IL-1B(-511), IL-1B(+3953), IL-1RN Intron 2 VNTR] and tissue necrosis factor (TNF)-α [TNFA(-308)] were measured healthy blood donors (healthy control subjects), patients with angiographically normal coronary arteries (patient single-vessel disease (SVD), those multivessel (MVD). Methods Results —Five hundred fifty-six attending for...
Background— There is a paucity of data on the use optimal medical therapy (OMT) in patients with complex coronary artery disease undergoing revascularization percutaneous intervention or bypass grafting (CABG) and its long-term prognostic significance. Methods Results— The Synergy Between Percutaneous Coronary Intervention With TAXUS Cardiac Surgery (SYNTAX) trial multicenter, randomized, clinical (n=1800) randomized to CABG. Detailed drug history was collected for all at discharge 1-month,...
Background Average life expectancy is rising, resulting in increasing numbers of elderly, frail individuals presenting with coronary artery disease and requiring percutaneous intervention (PCI). PCI can be value for this population, but little known about the balance benefit versus risk, particularly frail. Objective To determine relationship between frailty clinical outcomes patients undergoing PCI. Methods Patients PCI, either stable angina or acute syndrome, were prospectively assessed...
Measurement of fractional flow reserve (FFR) has an established role in guiding percutaneous coronary intervention. We tested the hypothesis that, at stage diagnostic invasive angiography, systematic FFR-guided assessment artery disease would be superior, terms resource use and quality life, to by angiography alone.We performed open-label, randomized, controlled trial 17 UK centers, recruiting 1100 patients undergoing for investigation stable angina or non-ST-segment-elevation myocardial...
We have read the research article “Rapid and Precise Computation of Fractional Flow Reserve from Routine Two-Dimensional Coronary Angiograms Based on Fluid Mechanics: The Pilot FFR2D Study” by Tsigkas et al [...]
Background —Angioplasty initiates a number of responses in the vessel wall including cellular migration, proliferation, and matrix accumulation, all which contribute to neointima formation restenosis. Cellular homeostasis within tissue depends on balance between cell proliferation apoptosis. Methods Results —Profiles apoptosis were therefore examined porcine PTCA injury model over 28-day period. Forty-two arteries from 21 pigs, harvested at site maximal 1, 6, 18 hours, 3, 7, 14, 28 days...
1. A meta-analysis of 17 years literature on erythrocyte Na+/Li+ countertransport (NLCT) and Na+/K+ co-transport (COT) measurements in relation to essential hypertension is presented. The analysis aimed answer two questions: (i) Which clinical or laboratory variables influence NLCT COT flux values? (ii) How useful are as a diagnostic aid hypertension? 2. Regression was performed the mean values relevant values. Studies both normotensive hypertensive subjects were stratified for which showed...
The inherent complexity of biomedical systems is well recognized; they are multiscale, multiscience systems, bridging a wide range temporal and spatial scales. While the importance multiscale modelling in this context increasingly recognized, there little underpinning literature on methodology generic description process. COAST (complex autonoma simulation technique) project aims to address by developing framework, coined complex (CxA), based hierarchical aggregation coupled cellular...
Average life expectancy is increasing in the western world resulting a growing number of frail individuals with coronary heart disease, often associated comorbidities. Decisions to proceed invasive interventions elderly patients challenging because they may gain benefit, but are also at risk procedure-related complications. Current scores designed predict mortality cardiac procedures mainly based on clinical and angiographic factors, limitations derived from middle-aged population, do not...
Pulmonary arterial hypertension is a devastating disease with high morbidity and mortality limited treatment options. Recent studies have shown that pulmonary artery denervation improves hemodynamics in an experimental model early clinical trial. We aimed to evaluate the nerve distribution around artery, determine effect of radiofrequency on acute induced by vasoconstriction, demonstrate at histological level.Histological evaluation identified circumferential nerves proximal arteries. Nerves...
Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard assessment but remains underused. The authors have developed a novel "pseudotransient" analysis protocol for computing virtual fractional (vFFR) based upon angiographic images and steady-state computational fluid dynamics. This generates vFFR results in 189 s (cf >24 h transient analysis) using desktop PC, with <1% error relative that of full-transient dynamics analysis. Sensitivity demonstrated...
Stent thrombosis (ST) is an infrequent but potentially fatal complication of PCI. The reported incidence ST varies from 0-5%, due to differences in definition ST, inclusion/exclusion criteria, and the type stent dual antiplatelet therapy used. We aimed examine associated risk factors this "real-world, all-comers" study.All patients undergoing PCI at South Yorkshire Cardiothoracic Centre (UK) between 2007 2010 were included, with no exclusion criteria. cases divided into definite probable...
Ticagrelor has superior efficacy to clopidogrel in the management of acute coronary syndromes but not been assessed patients undergoing percutaneous intervention for stable artery disease. We compared pharmacodynamic effects ticagrelor and this population.
To investigate the relative importance of stent induced arterial stretch and deep injury to development in-stent neointima.Normal porcine coronary arteries30 BiodivYsio stents (Biocompatibles) were deployed at a artery ratio 1.25:1 (a moderate injury) harvested 28 days. Multiple serial cross sections analysed morphometrically neointimal areas correlated with type degree injury.Arterial occurred in 78% struts (77% sections) produced growth (neointimal area 1.93 (0.13) mm2). Deep (rupture...
Acute Coronary Syndromes account for 15% of deaths in the UK, and patients remain at significant risk re-admission future complications death. Pathologically underlying process atherosclerosis is driven by inflammatory mechanisms, which are activated ACS patients. Previous studies have investigated role markers this process, including interleukin 1 (IL-1) C Reactive Protein (CRP). Pre-clinical indicate that IL-1 may be a primary driver naturally occurring interleukin-1 receptor antagonist...