A5079861099- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Laser Applications in Dentistry and Medicine
- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Neuroscience of respiration and sleep
- Ion channel regulation and function
- Cleft Lip and Palate Research
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Arrhythmias and Treatments
- Cell death mechanisms and regulation
- Temporomandibular Joint Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Nerve injury and regeneration
- ATP Synthase and ATPases Research
- Ion Channels and Receptors
- Botulinum Toxin and Related Neurological Disorders
- Antimicrobial Peptides and Activities
- Stress Responses and Cortisol
- Sulfur Compounds in Biology
- Orthodontics and Dentofacial Orthopedics
- Trigeminal Neuralgia and Treatments
- Atrial Fibrillation Management and Outcomes
Stomatology Hospital
2023-2025
Zhejiang University
2024-2025
Sichuan University
2018-2024
State Key Laboratory of Oral Diseases
2019-2024
West China Hospital of Sichuan University
2023
University of Oklahoma Health Sciences Center
2010
Fudan University
2009
Previous studies showed that autonomic activation by high-frequency electrical stimulation (HFS) during myocardial refractoriness evokes rapid firing from pulmonary vein (PV) and atria, both in vitro vivo. This study sought to investigate the mechanism underlying firings at various sites systematic ablation of multiple ganglionated plexi (GP). In 43 mongrel dogs, firing-mediated atrial fibrillation (AF) was induced local HFS (200 Hz, impulse duration 0.1 ms, train 40 ms) PVs atria...
Abstract Inflammatory orofacial pain, in which substance P (SP) plays an important role, is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs). SGC activation emerging as key mechanism underlying inflammatory pain through different signalling mechanisms, including fibrillary acidic protein (GFAP) activation, phosphorylation of mitogen-activated kinase (MAPK) pathways, cytokine upregulation. However, TG, SP-mediated generated by SGCs...
Abstract Satellite glial cells (SGCs) activation in the trigeminal ganglia (TG) is critical various abnormal orofacial sensation nerve injury and inflammatory conditions. SGCs express several subtypes of P2 purinergic receptors contributing to initiation maintenance neuropathic pain. The P2Y 14 receptor, a G‐protein‐coupled receptor activated by uridine diphosphate (UDP)‐glucose other UDP sugars, mediates physiologic events such as immune, inflammation, However, expression, distribution,...
The cross talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs) is crucial for the regulation of inflammatory orofacial pain. Substance P (SP) plays an important role by activating neurokinin (NK)-I receptors in this talk. activation extracellular signal-regulated kinase (ERK) 1/2, protein A (PKA) C (PKC) SGCs peripheral ganglions inflammation associated with hypersensitivity. This study tested hypothesis that SP evoked SP-NK-I receptor positive feedback via...
Background: Recent studies have demonstrated the contribution of non-coding RNAs (ncRNAs) to neuropathic pain. However, expression profile ncRNAs in trigeminal ganglion (TG) and their functional mechanism underlying pain are still unclear. Methods: In present study, model induced by chronic constriction injury infraorbital nerve (CCI-ION) was used study potential regulatory miRNAs, lncRNAs, circRNAs, mRNAs TG RNA-sequencing (RNA-seq) bioinformatics analysis. CCI-ION mice suffered from...
The involvement of inwardly rectifying potassium channel 4.1 (Kir4.1) in neuropathic pain has been established. However, there is limited understanding the downstream mechanism through which Kir4.1 contributes to orofacial pain. objective this study was examine regulation on expression pannexin 3 (Panx3) trigeminal ganglion (TG) and underlying context caused by chronic constriction injury infraorbital nerve (CCI-ION). observed a significant increase Panx3 TG mice with CCI-ION. Inhibition...
This study explores the effects of oxytocin receptor (OXTR) in trigeminal ganglion (TG) on orofacial neuropathic pain. We demonstrate that OXTR activation TG relieves ectopic pain as well inhibits upregulated expression calcitonin gene-related peptide, IL-1β, and TNF-α spinal nucleus caudalis rats with inferior alveolar nerve transection.
Mechanical force–induced external root resorption is a major clinical side effect of orthodontic treatment. Recent work has revealed that M1 macrophages play vital role in promoting (ORR), but the mechanism how mechanical force stimulation increases M1/M2 macrophage ratio periodontal tissue poorly understood. In current study, we showed C-X-C motif chemokine 12 (CXCL12) + ligament cells (PDLCs) and receptor type 4 (CXCR4) monocytes (PDL) were significantly increased after application with...
Orofacial ectopic pain induced by trigeminal nerve injury is a serious complication of dental treatment. C-X-C motif chemokine ligand 1 (CXCL1) and its primary receptor 2 (CXCR2) contribute to the development maintenance neuropathic in spinal nervous system, but their roles sensation are still poorly understood.This study aimed investigate exact role CXCL1 CXCR2 regulation orofacial mechanical allodynia potential downstream mechanisms ganglion (TG).The head withdrawal threshold (HWT) C57BL/6...
Inward-rectifying K+ channel 4.1 (Kir4.1), which regulates the electrophysiological properties of neurons and glia by affecting homeostasis, plays a critical role in neuropathic pain. Metabotropic glutamate receptor 5 (mGluR5) expression Kir4.1 retinal Müller cells. However, its expressional regulatory mechanisms underlying orofacial ectopic allodynia remain unclear. This study aimed to investigate biological roles mGluR5 trigeminal ganglion (TG) mechanical regulation. An animal model nerve...
Objective: To measure the validity and reliability of a Chinese version Child Oral Health Impact Profile (COHIP) to assess oral health-related quality life (OHRQoL) with regard gender, age, cleft types in children orofacial (OFC). Design: A total 120 patients OFC (8-15 years old) their parents were investigated COHIP West China Hospital Stomatology. Items divided into symptoms, functional well-being, emotional school, peer interaction subscales, scores on all subscales compared between...