A5100704563- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Effects and risks of endocrine disrupting chemicals
- Protein Tyrosine Phosphatases
- Glycosylation and Glycoproteins Research
- Water Quality Monitoring and Analysis
- Advanced Fluorescence Microscopy Techniques
- Galectins and Cancer Biology
- Single-cell and spatial transcriptomics
- Spectroscopy and Chemometric Analyses
- Pharmacological Effects and Assays
- Pharmaceutical and Antibiotic Environmental Impacts
- Cell Image Analysis Techniques
- Axon Guidance and Neuronal Signaling
Chan Zuckerberg Initiative (United States)
2025
University of Illinois Urbana-Champaign
2024-2025
Indian Institute of Science Education and Research Kolkata
2020-2024
Abstract Ligand-independent activation of VEGFRs is a hallmark diabetes and several cancers. Like EGFR, VEGFR2 activated spontaneously at high receptor concentrations. VEGFR1, on the other hand, remains constitutively inactive in unligated state, making it an exception among VEGFRs. Ligand stimulation transiently phosphorylates VEGFR1 induces weak kinase endothelial cells. Recent studies, however, suggest that signaling indispensable regulating various physiological or pathological events....
Hepatocyte polyploidy and maturity are critical to acquiring specialized liver functions. Multiple intracellular extracellular factors influence ploidy, but how they cooperate temporally steer polyploidization maturation or post-transcriptional mechanisms integrate into these paradigms is unknown. Here, we identified an important regulatory hierarchy in which postnatal activation of epithelial splicing protein 2 (ESRP2) stimulates processing liver-specific microRNA ( miR-122 ) facilitate...
SUMMARY Hepatocyte polyploidy and maturity are critical to acquiring specialized liver functions. Multiple intra- extracellular factors influence ploidy, but how they cooperate temporally steer polyploidization maturation or post-transcriptional mechanisms integrate into these paradigms is unknown. Here, we identified an important regulatory hierarchy in which postnatal activation of Epithelial-Splicing-Regulatory-Protein-2 (ESRP2) stimulates biogenesis liver-specific microRNA (miR-122),...
Various types of naturally occurring and artificially made chemicals cause disruption endocrine processes among animals. They mimic biochemically with hormones interfere the normal signaling activity system, causing enormous changes at cellular level animals from lower to higher organisms, including human being. These modified regulations activities as a result disruptors have severe implications organismal level. Types adverse effects these natural synthetic agents, especially estrogenic...
ABSTRACT Individuals with progressive liver failure are at a high risk of mortality without transplantation. However, our understanding derailed regenerative responses in failing livers is limited. Here, we performed comprehensive multi-omic profiling healthy and diseased human using bulk single-nucleus RNA-plus ATAC-seq. We report that hepatic immune milieu alterations alcohol-associated disease (ALD) prevent hepatocytes from transitioning to proliferative progenitor-like state, trapping...
Abstract Ligand-independent activation of VEGFR is a hallmark in diabetes and several cancers. Like most RTKs, the VEGFR2, primary VEGF receptor, activated spontaneously at higher receptor concentrations. An exception VEGFR1, which remains constitutively inactive basal state. Ligand stimulation transiently phosphorylates VEGFR1 induces weak kinase endothelial cells. Recent studies, however, suggest that signaling indispensable regulating various physiological or pathological events,...