A5034146453- Angiogenesis and VEGF in Cancer
- Protein Tyrosine Phosphatases
- Axon Guidance and Neuronal Signaling
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
Indian Institute of Science Education and Research Kolkata
2024
Abstract Ligand-independent activation of VEGFRs is a hallmark diabetes and several cancers. Like EGFR, VEGFR2 activated spontaneously at high receptor concentrations. VEGFR1, on the other hand, remains constitutively inactive in unligated state, making it an exception among VEGFRs. Ligand stimulation transiently phosphorylates VEGFR1 induces weak kinase endothelial cells. Recent studies, however, suggest that signaling indispensable regulating various physiological or pathological events....
Abstract Ligand-independent activation of VEGFR is a hallmark in diabetes and several cancers. Like most RTKs, the VEGFR2, primary VEGF receptor, activated spontaneously at higher receptor concentrations. An exception VEGFR1, which remains constitutively inactive basal state. Ligand stimulation transiently phosphorylates VEGFR1 induces weak kinase endothelial cells. Recent studies, however, suggest that signaling indispensable regulating various physiological or pathological events,...