A5102921685- Agricultural Science and Fertilization
- Clay minerals and soil interactions
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Soil and Land Suitability Analysis
- Mine drainage and remediation techniques
- RNA and protein synthesis mechanisms
- Pharmacological Effects of Natural Compounds
- Global Public Health Policies and Epidemiology
- Soil and Unsaturated Flow
- Tryptophan and brain disorders
- Mosquito-borne diseases and control
- Colorectal Cancer Surgical Treatments
- Geomagnetism and Paleomagnetism Studies
- Phytochemical compounds biological activities
- Estrogen and related hormone effects
- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- Bioactive Compounds and Antitumor Agents
- Cancer-related molecular mechanisms research
- Advanced Welding Techniques Analysis
- Nutrition, Genetics, and Disease
- Geophysical and Geoelectrical Methods
- Phagocytosis and Immune Regulation
- Indigenous Knowledge Systems and Agriculture
Institute of Genomics and Integrative Biology
2024-2025
Indian Institute of Science Education and Research Kolkata
2024
Netaji Subhas Chandra Bose Cancer Research Institute
2012-2015
Geological Survey of India
2012
Abstract The clinical success of CRISPR therapies hinges on the safety and efficacy Cas proteins. Cas9 from Francisella novicida (FnCas9) is highly precise, with a negligible affinity for mismatched substrates, but its low cellular targeting efficiency limits therapeutic use. Here, we rationally engineer protein to develop enhanced FnCas9 (enFnCas9) variants broaden their accessibility across human genomic sites by ~3.5-fold. enFnCas9 proteins single mismatch specificity expanded target...
Abstract Ligand-independent activation of VEGFRs is a hallmark diabetes and several cancers. Like EGFR, VEGFR2 activated spontaneously at high receptor concentrations. VEGFR1, on the other hand, remains constitutively inactive in unligated state, making it an exception among VEGFRs. Ligand stimulation transiently phosphorylates VEGFR1 induces weak kinase endothelial cells. Recent studies, however, suggest that signaling indispensable regulating various physiological or pathological events....
Aluminium Metal Matrix Composite (MMC) is gradually gaining popularity in various engineering applications. This due to their light weight and favourable physical chemical properties. Weldability study of them is, therefore, important facilitate fabrication components. In this work, autogeneous bead-on-plate TIG welding Al-7.7%-SiC MMC was performed using Argon as the shielding gas. Heat input gas flow rate were variables. Central Design (CCD) Response Surface Methodology (RSM) design...
Megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare and progressive neurodegenerative disorder involving the white matter, is not adequately recapitulated by current disease models. Somatic cell reprogramming, along advancements in genome engineering, may allow establishment of in-vitro human models MLC for modeling drug screening. In this study, we utilized cellular reprogramming gene-editing techniques to develop induced pluripotent stem (iPSC) recapitulate context...
Abstract Ionic imbalance in the tumor microenvironment alters tumor-infiltrating T lymphocyte function. High extracellular K + suppresses cell function by negatively regulating receptor (TCR) signaling. In contrast, elevated Na enhances effector boosting phosphorylation of TCR signaling modules. Here, we presented a mechanism explaining how two monovalent cations differently regulate At rest, high intracellular uncouples allosteric recruitment ZAP-70, key module, to complex. The formation...
Background: Subfertility is a growing reproductive health concern globally, with obesity increasingly recognized as contributing factor affecting ovarian reserve. Anti-Mullerian Hormone (AMH) serves reliable marker of reserve, and its relationship body mass index (BMI) remains subject clinical significance. Aim the Study: To find out association between BMI categories serum AMH levels in sub fertile women. Methods: A cross-sectional analytical study was conducted at Department Obstetrics...
There are surprisingly few RNA intramolecular triple helices known in the human transcriptome. The structure has been most well-studied as a stability-element at 3' end of lncRNAs such
Abstract Ligand-independent activation of VEGFR is a hallmark in diabetes and several cancers. Like most RTKs, the VEGFR2, primary VEGF receptor, activated spontaneously at higher receptor concentrations. An exception VEGFR1, which remains constitutively inactive basal state. Ligand stimulation transiently phosphorylates VEGFR1 induces weak kinase endothelial cells. Recent studies, however, suggest that signaling indispensable regulating various physiological or pathological events,...