A5100731293- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Bone Tissue Engineering Materials
- Advanced Drug Delivery Systems
- Intraocular Surgery and Lenses
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Corneal surgery and disorders
- Advanced Chemical Sensor Technologies
- Hydrogels: synthesis, properties, applications
- Photonic Crystals and Applications
- Nerve injury and regeneration
- Gas Sensing Nanomaterials and Sensors
- Spectroscopy and Laser Applications
- Nanoparticle-Based Drug Delivery
- Simulation and Modeling Applications
- Fungal Biology and Applications
- 3D Printing in Biomedical Research
- Graphene research and applications
- Facial Trauma and Fracture Management
- Polymer Surface Interaction Studies
- Periodontal Regeneration and Treatments
- Vascular Malformations and Hemangiomas
- Corporate Identity and Reputation
- Mycorrhizal Fungi and Plant Interactions
University of Chinese Academy of Sciences
2013-2025
Wenzhou Medical University
2015-2025
Anqing Normal University
2016-2025
Shenzhen Institutes of Advanced Technology
2021-2025
Chinese Academy of Sciences
2010-2025
Affiliated Eye Hospital of Wenzhou Medical College
2014-2025
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Zhejiang University
2024
Hangzhou Seventh Peoples Hospital
2024
In this study, an injectable, photocurable gelatin system, consisting of acrylated and thiolated gelatin, with tunable mechanical, biodegradation, biological properties was used as a potential cell-supportive scaffold for the repair focal corneal wounds. The mechanical property hydrogels can be readily modified (postcure shear modulus between 0.3 22 kPa) by varying ratio acrylate to thiol groups, photointensity, solid content, biodegradation times also varied change content. More...
Due to the limitations in autogenous nerve grafting or Schwann cell transplantation, large gap peripheral injuries require a bridging strategy supported by conduit. Cell based therapies provide novel treatment for injuries. In this study, we first experimented an optimal scaffold material synthesis protocol, from where selected 10% GFD formula (10% GelMA hydrogel, recombinant human basic fibroblast growth factor and dental pulp stem cells (DPSCs)) fill cellulose/soy protein isolate composite...
Stable graphene oxide monoliths (GOMs) have been fabricated by exploiting epoxy groups on the surface of (GO) in a ring opening reaction with amine poly(oxypropylene) diamines (D 400 ). This method can rapidly form covalently bonded GOM D within 60 s. FTIR and XPS analyses confirm formation covalent C‐N bonds. Investigation mechanism reveals that interaction GO diamine cross‐linker result 3 different assemblies depending ratio to GO, which proven both experiment molecular dynamics...
Because of their ease handling and excellent biocompatibility, injectable macroporous hydrogels have received a considerable interest in the fields tissue engineering drug delivery systems because unique application minimally invasive surgical procedures. In this study, situ forming, injectable, macroporous, self-healing gelatin (GE)/oxidized alginate (OSA)/adipic acid dihydrazide (ADH) were prepared using high-speed shearing treatment stabilized by Schiff base reaction acylhydrazone bonds....
Abstract The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half‐life in vivo. Thus there is a need for drug delivery system that acts as reservoir and releases the remotely “on demand”. Here we demonstrate simple light‐triggered local through photo‐thermal interactions polymer‐coated gold nanoparticles (AuNPs) inside an agarose hydrogel therapeutic depot. Localized temperature increase induced by visible...
Bacterial infections and biofilm formation on the surface of implants are important issues that greatly affect biomedical applications even cause device failure. Construction high drug loading systems control release on-demand is an efficient way to lower development resistant bacteria formation. In present study, (montmorillonite/hyaluronic acid-gentamicin)10 ((MMT/HA-GS)10) organic/inorganic hybrid multilayer films were alternately self-assembled substrates. The dosage GS was as 0.85...
An innovative and miniature photoacoustic spectroscopy (PAS) gas sensor based on a multivariate-coupled amplification cell (MVCA-PAC) with total length of 100 mm was developed to achieve ultra-sensitive trace CH4 detection. Acoustic pressure distribution simulations reveal that at the first-order resonance frequency, MVCA-PAC achieves maximum acoustic approximately 3.9 times higher than conventional cell. The absorption optical path reached 2068 through 22 reflections, resulting in 2-fold...
Vascularization is an essential step in successful bone tissue engineering. The induction of angiogenesis engineering can be enhanced through the delivery therapeutic agents that stimulate vessel and formation. In this study, we show cucurbitacin B (CuB), a tetracyclic terpene derived from Cucurbitaceae family plants, facilitates vitro.We incorporated CuB into biodegradable poly (lactide-co-glycolide) (PLGA) β-tricalcium phosphate (β-TCP) biomaterial scaffold (PT/CuB) Using 3D...
Nitrogen-doped graphene nanoribbon aerogel (N-GNRA) fabricated through self-assembly of oxide nanoribbons shows potential applications in lithium storage and the biomedical field.
Abstract The use of biomacromolecular therapeutics has revolutionized disease treatment, but frequent injections are required owing to their short half‐life in vivo. Thus there is a need for drug delivery system that acts as reservoir and releases the remotely “on demand”. Here we demonstrate simple light‐triggered local through photo‐thermal interactions polymer‐coated gold nanoparticles (AuNPs) inside an agarose hydrogel therapeutic depot. Localized temperature increase induced by visible...
This paper presents a novel double network scaffold and its preparation methods, in which cell-affinitive hydrogel was made by poly(2-hydroxyethyl methacrylate) modified gelatin.
Large bone defect repair is a challenging clinical problem due to limited self-repair ability. A well-designed filling product should possess the ability induce tissue in-growth and facilitate neovascularization new formation. Puerarin has been used in clinics for long time, recently it was found be able promote osteogenesis. This study aimed investigate puerarin-based drug/delivery combination implant promoting large repair.Puerarin incorporated into poly (lactic-co-glycolic acid)/β-calcium...
Targeted delivery of cytotoxic drugs to tumour tissue has great importance for successful chemotherapy. Legumain is an asparaginyl endopeptidase that highly up-regulated in a number solid tumours. The aim this work was prepare novel hyaluronic acid (HA) based legumain sensitive nanogel the doxorubicin with high targeting efficiency both vitro and vivo. property achieved by conjugation HA via substrate peptide bridge. This derivative further crosslinked water/oil solvent system form polygonal...
This study presents a cornea-on-a-chip model for bacterial keratitis, elucidating antibiotic effectiveness in terms of eradication, cellular apoptosis reduction, and scar formation mitigation, offering new insights ocular drug testing.