A5002005990- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Iron Metabolism and Disorders
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Hemoglobinopathies and Related Disorders
- Cancer therapeutics and mechanisms
- Cardiovascular Health and Disease Prevention
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Lysosomal Storage Disorders Research
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Heparin-Induced Thrombocytopenia and Thrombosis
- Viral-associated cancers and disorders
- PI3K/AKT/mTOR signaling in cancer
Walter and Eliza Hall Institute of Medical Research
2016-2025
The University of Melbourne
2013-2025
Monash Health
2016-2025
Monash University
2016-2025
Monash Medical Centre
2020-2022
Australian Regenerative Medicine Institute
2021
Hudson Institute of Medical Research
2018-2019
Monash Children’s Hospital
2019
The Alfred Hospital
2012-2015
Alfred Health
2014-2015
The transcription factor interferon regulatory 4 (IRF4) is critical for the development, maintenance, and function of plasma cells. mechanism by which IRF4 exerts its action in mature cells has been elusive due to death all such upon loss. While we identify apoptosis as a pathway caused loss, also determine that did not regulate intrinsic apoptotic directly. By using an inducible deletion system presence overexpression anti-apoptotic BCL2, genes whose expression coordinated turn specify cell...
Fabry disease is a rare X-linked inborn error of glycosphingolipid metabolism. The aim this study was to document the ophthalmological manifestations patients attending Royal Melbourne Hospital treatment centre.Patients at centre had full examination performed. This included best corrected visual acuity, ocular motility and adnexae. Patients also underwent slit-lamp looking for presence features disease, particularly examining bulbar conjunctiva, cornea, lens fundus.Thirty-four hemizygous...
Abstract B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature cells. This highly regulated process generates clonal immunological diversity via recombination immunoglobulin V, D and J gene segments. While several transcription factors that control cell V(D)J have been defined, how these processes are coordinated a precise regulatory network remains poorly understood. Here, we show factor ETS...
Flow characteristics are examined in two lateral model aneurysms by means of numerical simulation. The study concentrates on basic flow and stress patterns a rigid wall distensible aneurysm. solution the governing Navier-Stokes equations describing incompressible, pulsatile, three-dimensional non-Newtonian is accomplished with use finite element method together pressure correction technique. inflow into aneurysm seen to arise from downstream lip orifice be directed backward center. Backflow...
Abstract Background: Fabry disease has diverse neurological manifestations, many of which influence morbidity and quality life. Aims: The aim the study was to document clinical subclinical manifestations in a cohort Australian patients with disease, using multiple tools multidisciplinary approach. Methods: Participants completed focused questionnaires underwent examination, Neurocognitive testing Mini Mental State Examination Neuropsychiatry Unit Cognitive Screen, Quantitative Sensory...
Summary Central nervous system ( CNS ) multiple myeloma MM is exceedingly rare and portends a dismal prognosis. While immunomodulators have contributed to the improvement in survival , they appear limited activity against and, paradoxically, may contribute evolution of resistant clones capable surviving within . We undertook retrospective analysis characterize features outcome 17 patients from four institutions identified between 2000 2011. The median age was 58 years. Patients had received...
After pharmaceutical benefits scheme approval of midostaurin for fms-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukaemia (AML) in 2018, the Australasian Leukaemia & Lymphoma Group (ALLG) proposed a consensus approach to AML induction with 7+3 chemotherapy (7 days infusional cytarabine three doses anthracycline) align future clinical trial protocols. To determine efficacy and safety idarubicin-based ± (per ALLG recommendations) real-world, tertiary hospital setting. Data were...
Abstract BH3 mimetic drugs that selectively target the pro-survival BCL2 proteins are highly promising for cancer treatment, most notably treating blood cancers. Venetoclax, which inhibits BCL2, is now approved chronic lymphocytic leukemia (CLL) and acute myeloid (AML). Preferably, robust validated assays would identify patients likely to benefit from therapy with venetoclax itself or inhibitors of other proteins. A sophisticated method has been developed profiling assay. In this assay,...
There is limited data describing dexamethasone, cyclophosphamide, etoposide, and cisplatin (DCEP) in relapsed refractory multiple myeloma (RRMM). We reviewed 65 patients with RRMM receiving DCEP between 2005 2017 two Melbourne Hospitals. Patients had received a mean of three prior treatment lines (range, 1-11). The number cycles was 1-4). Overall response rate (ORR) 55% whilst 19% achieved MR SD. Median overall survival (OS) 9.6 months. Those bridged to autologous stem cell transplant (ASCT)...
Coronavirus disease 2019 (COVID-19) infection in patients with haematological neoplasms has been associated increased mortality; however, many studies this patient group were reported early the pandemic. The authors evaluated outcomes of COVID-19 conditions following widespread vaccination, newer viral variants and increasingly effective antiviral therapies. A 4% mortality rate was found contemporary risk factors for hospitalisation including older age, nonvaccination or partial vaccination...
The prognostic impact of t(11;14) in multiple myeloma (MM) needs to be better understood inform future treatment decisions. Australian Lymphoma Leukaemia Group embarked on a retrospective, observational cohort study using real-world data interrogate patterns and outcomes 74 MM patients with [t(11;14)-MM] diagnosed over 10 years. This was compared 159 111 high-risk IgH translocations (IgH HR-MM) hyperdiploidy (Hyperdiploid-MM), respectively, from the Myeloma Related Diseases Registry. No...
Background: Indolent T cell lymphoproliferation of the gastrointestinal tract is a novel entity recently added to 2016 WHO classification lymphoid neoplasms. Classically, these patients demonstrate an immunophenotype consistent with proliferation and can be either CD4-positive or CD8-positive but low Ki67 index, highlighting indolent nature this disease compared its more aggressive lymphoma counterparts such as enteropathy-associated monomorphic epitheliotropic intestinal lymphoma. Methods:...