A5008876218- HIV Research and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Hepatitis Viruses Studies and Epidemiology
- HIV, Drug Use, Sexual Risk
- Assisted Reproductive Technology and Twin Pregnancy
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Bioinformatics and Genomic Networks
- RNA Interference and Gene Delivery
- Protein Degradation and Inhibitors
Saint Petersburg Pasteur Institute
2022-2025
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2023
The aim of the study was to search for candidate genes interacting with HIV attachment receptors (CCR5, CXCR4, CCR2, CD4) and potentially involved in disease pathogenesis, based on complex silico network algorithms. Materials methods. A number web applications were used analyse genetic protein-protein networks, algorithms databases which are complementary. CD4 receptor chemokine co-receptor CCR5, CXCR4 CCR2 as background/baseline all cases, their protein products play a key role process...
Background: Vietnam has made significant strides in reducing the prevalence of HIV infection and achievements its antiretroviral treatment program. However, COVID-19 pandemic financial challenges healthcare system have posed obstacles to maintaining effective monitoring, particularly among vulnerable populations. This study aims evaluate situation drug resistance patients who experienced failure Mekong Delta region compare data from 2019 2022. Methods: The material was blood plasma samples...
Healthcare workers are much more likely to be infected with HIV and hepatitis viruses compared the general population. Although healthcare aware of viruses, several countries in Africa lack a comprehensive grasp disease routes transmission risks. The aim this study was assess prevalence serological molecular biological markers viral among Republic Guinea. material 74 blood serum samples collected from who received additional training at Institute Applied Biological Research Guinea (IRBAG,...
According to the latest data released by UNAIDS, global number of people living with HIV (PLHIV) in 2021 was 38.4 million, 1.5 million new infections. In different countries, a significant proportion these cases occur adult fertile population aged 15-49 years. Vietnam had national prevalence 0.3% total at end 2019, approximately 230,000 PLHIV. The most effective way prevent mother-to-child transmission is ART reduce maternal viral load. HIV-infected pregnant women should undergo monthly...
The Vietnam Ministry of Health (MOH) has intensified efforts in its aim to eliminate AIDS by 2030. Expanding the program for prevention mother-to-child transmission (PMTCT) is a significant step towards achieving this goal. However, there are still HIV-exposed children who do not have access PMTCT services, and some participated but contracted HIV. This study focused on assessing prevalence profile HIV mutations among under 18 months age had recently tested positive HIV, while gaining...
The aim of the study was to assess occurrence serological and molecular genetic markers HIV infection, viral hepatitis B C among persons in pre-trial detention. Materials methods. material identified 138 samples blood sequences obtained from men pretrial detention center St. Petersburg. Patients were examined by ELISA for presence infection (Ag/Ab HIV), HBV (HBsAg, antiHBs IgG, anti-HBcore IgG) HCV (anti-HCV IgG). Determination RNA, as well DNA PCR with hybridization-fluorescence detection...
Introduction. The spread of the human immunodeficiency virus type 1 (HIV-1) has become a global concern and approached pandemic status. St. Petersburg, major transportation, tourist, cultural, industrial center, border city, is characterized by high migration population. growing number migrants can contribute to importation new genetic variants trigger recombination processes in population Petersburg Leningrad Region.The aim characterize present-day HIV-1 subtype-specific profile...
The aim of the work is to assess prevalence hepatitis B virus drug resistance mutations and immune escape in pregnant women Republic Guinea.
 Materials methods. Blood plasma samples obtained from 480 different regions Guinea with laboratory-confirmed viral were studied. Nucleotide sequences for genotype identification mutation detection using nested-PCR followed by Sanger sequencing, based on overlapping pairs primers spanning complete genome virus.
 Results discussion. In examined...
Background. In Vietnam, there has been an increase in efforts to monitor and prevent mother-to-child transmission of HIV since 2013. However, data on drug resistance among HIV-1 infected children younger than 18 months age remain limited. The study fills a critical knowledge gap by providing important insights into the prevalence this population Southern Central Highland provinces Vietnam. Objective. This aimed determine patterns mutation treatment-naïve under who had recently diagnosed with...
The aim of this study was to assess the prevalence and molecular genetic characteristics human immunodeficiency virus in pregnant women Republic Guinea. Materials methods. material for blood plasma samples 972 from patients were examined presence HIV infection serological (Ag+Ab) markers (RNA). For with a positive PCR result sufficient viral load (>500 c/ml), sequences pol gene fragment responsible synthesis pro rev proteins obtained by Sanger sequencing. These used phylogenetic analysis...
The aim of the study was to determine tropism human immunodeficiency virus in patients with virological failure antiretroviral therapy (ART) from Arkhangelsk Region based on analysis env gene V3 loop nucleotide sequence. Materials and methods . We used blood plasma samples obtained 76 HIV-infected persons therapy. sequences HIV C2-V3-C3 region were studied by PCR followed sequencing. genotype strains determined their phylogenetic relations reference international GenBank database, as well...
Introduction. Assessing interaction between the human immunodeficiency virus (HIV) and factors is crucial for understanding disease pathogenesis. HIV triggers an immune response that involves numerous cellular molecular processes related to inflammation, cell migration, disrupted tissue barrier functions. Such reactions build up a cascade in which chemokines cognate co-receptors, as well other molecules regulating response, play key role. However, organism cannot be reduced simple mechanism...
The problem of transfusion safety preventing parenteral viral hepatitis transmission remains relevant. Viral B (HB) is the most common infection transmitted through procedures. One natural phases a chronic (CHB) course occult (OBI) characterized by undetectable HBsAg level (regardless other serological marker levels) along with detected hepatic HBV DNA as well blood load ranging from extremely low to undetectable. In Vietnam, prevention transfusion-based focused on donor screening; it still...
The HIV-infection continues to be one of the most large-scale epidemics worldwide. Many techniques have been developed detect this disease, but Western blot based on identification specific viral proteins remains commonly used method that allows monitor ongoing processes. Despite discussions regarding criteria for a positive test assessment and selection minimum number reliably interpret data, very few studies protein profiles in HIV-infected patients, particularly Russian Federation are...
The aim of our work was to assess the occurrence serological and molecular-biological markers HIV, HBV HCV among medical workers from St. Petersburg. Materials methods . study material included 171 blood plasma samples ELISA method used qualitatively determine HIV antigen/antibodies (Ag/Ab), HBsAg, antibodies HBs HBcore proteins (anti-HBs IgG, anti-HBcore total), anti-HCV IgG. RNA, RNA DNA were detected by PCR. For all identified samples, sequencing subsequent analysis nucleotide sequences...
The aim of the work was to estimate prevalence HIV, HBV and HCV markers among pregnant women their male partners in Republic Guinea. Materials methods. material study blood plasma samples from 140 living Kindia prefecture N’Zerekore prefecture, as well 60 who reported sexual contact with HIV-infected persons. were examined for presence serological (HBsAg, HBeAg, antibodies anti-HBs IgG, anti-HBcore anti-HBe anti-HCV Ag/Ab-HIV) molecular (HBV DNA, RNA, HIV RNA) markers. Results discussion....
The aim of this study was to assess the prevalence occult hepatitis B infection among blood donors in St. Petersburg, as well characterize identified virus isolates. material represented by 2800 plasma samples collected 2019 from living Petersburg. ELISA for HBV marker rate consisted HBsAg, anti-HBs IgG, anti-HBcore IgG. DNA analyzed nested PCR with real-time hybridization-fluorescence detection on three targets allowing determine at low viral load, including HBsAg-negative chronic B....