A5020511668- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organic Light-Emitting Diodes Research
- Estrogen and related hormone effects
- Protein Kinase Regulation and GTPase Signaling
- Molecular Junctions and Nanostructures
- DNA and Nucleic Acid Chemistry
- Synthesis and biological activity
- TiO2 Photocatalysis and Solar Cells
- Magnetism in coordination complexes
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Advanced Photocatalysis Techniques
- Electrocatalysts for Energy Conversion
- Cytokine Signaling Pathways and Interactions
- Mast cells and histamine
- Computational Drug Discovery Methods
- Semiconductor Lasers and Optical Devices
- Photochemistry and Electron Transfer Studies
- Lanthanide and Transition Metal Complexes
- Ammonia Synthesis and Nitrogen Reduction
- Synthesis and Biological Evaluation
- Chemical Reactions and Isotopes
- Synthesis and Characterization of Heterocyclic Compounds
- Steroid Chemistry and Biochemistry
Gdańsk University of Technology
2020-2025
The feature of abundant and environmentally friendly heavy atoms (HAs) like bromine to accelerate spin-forbidden transitions in organic molecules has been known for years. In combination with the easiness incorporation, derivatives emitters showing thermally activated delayed fluorescence (TADF) emerge as a cheap efficient solution slow reverse intersystem crossing (rISC) problem such strong efficiency roll-off all-organic light-emitting diodes (OLEDs). Here, we present comprehensive...
The beauty and complexity of organic materials stem from the intricate interplay their structural effects, where same substituent can prove highly beneficial in one position yet entirely redundant...
We present here the advances achieved in development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives as potent steroid sulfatase (STS) inhibitors for treatment breast cancer. Prompted by promising biological results and silico analysis, initial series similar compounds were extended, appending a variety m-substituents at outer phenyl ring. The inhibition profiles newly synthesized evaluated using radioisotope enzymatic assay and, together with preceding reported...
When modified uridine derivatives are incorporated into DNA, radical species may form that cause DNA damage. This category of molecules has been proposed as radiosensitizers and is currently being researched. Here, we study electron attachment to 5-bromo-4-thiouracil (BrSU), a uracil derivative, 5-bromo-4-thio-2′-deoxyuridine (BrSdU), with an attached deoxyribose moiety via the N-glycosidic (N1-C) bond. Quadrupole mass spectrometry was used detect anionic products dissociative (DEA),...
In the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL from coronavirus SARS-CoV-2). Within set inhibitors, 6e demonstrated highest activity with IC50 value 8.52 ± 0.44 µM. for Nirmatrelvir (PF-07321332, used as reference) was 0.84 0.37 cytotoxic properties determined MTT MRC-5 and HEK-293 cell lines. course investigation, found...
Abstract In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within set STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl 3L demonstrated highest activity in enzymatic assay inhibiting to 7.98% at 0.5 µM concentration. Furthermore, verify whether obtained are able pass through cellular membrane effectively, cell line experiments have been...
Herein, we present the synthesis and crystal structures determination of five 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives containing halogen atoms, 6a–e, which may be used as an excellent mimic steroids in drug development process. Good quality crystals obtained for all synthesized compounds allowed analysis their molecular structures. Subsequently, determined were to calculate Hirshfeld surfaces each compounds. Furthermore, results our docking studies indicated that are able bind...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
8-Thiomethyladenine (ASCH
In the present work, we report development of a rapid, efficient, and solvent-free procedure for N-methylation secondary amines under mechanochemical conditions. After optimization milling parameters, vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives in short time 20 min (30 Hz frequency) high yields ranging from 78 95%. An exception compounds having hydroxyl group their structure, which decrease reaction efficiency observed. During our research,...
High hopes have been placed on the organic emitters, which are supposed to solve problem of low stability blue OLEDs. The phenomenon thermally activated delayed fluorescence (TADF),...
Abstract In the present work, we report development of a rapid, efficient, and solvent-free procedure for N-methylation secondary amines under mechanochemical conditions. After optimization milling parameters, vibrational ball mill was used to synthesize 26 tertiary N-methylated amine derivatives. During our research, investigated alternate reaction selectivity occurring in compounds able form ring closure products that are 3,4-dihydro-2H-1,3-benzoxazine derivatives instead products. The...