A5037498451- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
Guizhou Provincial People's Hospital
2012-2023
Guiyang Medical University
2017-2020
Guizhou University
2020
Affiliated Hospital of Guizhou Medical University
2017
The proliferation and migration of vascular smooth muscle cells are significant in the development progression atherosclerosis plaque rupture. Metformin is a widely used antidiabetic drug, which has been reported to inhibit cell growth migration. antiproliferative antimigratory effects metformin have attributed 5' adenosine monophosphate-activated protein kinase (AMPK) activation. purpose present study was investigate on primary human aortic (HASMCs) vitro clarify underlying mechanism. We...
Metformin has been shown to inhibit the proliferation and migration of vascular wall cells. However, mechanism through which metformin acts on atherosclerosis (AS) via long non-coding RNA taurine up-regulated gene 1 (lncRNA TUG1) is still unknown. Thus, this research investigated effect lncRNA TUG1 AS.First, qRT-PCR was used detect expression in patients with coronary heart disease (CHD). Then, correlation between vitro their effects proliferation, migration, autophagy cells were examined....
Abstract Apoptosis of vascular endothelial cells (VECs) is highly important in the occurrence and development atherosclerosis (AS). HomeboxC6 (HOXC6) expressed higher levels multiple malignant tissues, it influences biological behavior cancer cells. However, effects HOXC6 on AS apoptosis VECs have not been fully elucidated. In this study, we demonstrated that expression was increased aortic wall rats peripheral blood monocytes patients with coronary heart disease. Furthermore, uncovered BAX...
Homeobox c6 (Hoxc6) affects the proliferation, migration, and infiltration of malignant tumor cells; however, effect Hoxc6 on atherosclerosis (AS) as well proliferation migration vascular smooth muscle cells (VSMCs), which play a role in promoting AS, has not yet been clarified. In present study, we tested hypothesis that rat VSMCs, hence is involved AS. The results showed expression mRNA protein was higher normal aortic wall than myocardium. Subsequently, model AS established by high-fat...
Abstract Despite the substantial progress in deciphering pathogenesis of atherosclerosis (AS), cardiovascular mortality is still increasing. Therefore, atherosclerotic disease remains a sweeping epidemic that jeopardizes human health. Disentangling molecular underpinnings AS imperative cardiology field. Overwhelming evidence has indicated recognition fascinating class players, known as long non-coding RNAs (lncRNAs), provides causality for coordinating AS. However, function and mechanism...