Mobilisation within the first day following hip fracture surgery is recommended. However, an in-depth analysis of association between early mobilisation and risk infection lacking. To examine subsequent hospital-treated infections surgery. Using nationwide registries, we included 36 229 patients aged ≥65 who underwent for (2016-21). Exposure was time from to in hours. Outcomes were any infection, pneumonia, urinary tract sepsis 2-30 days reoperation due surgical-site 2-365 We calculated...

The health-care databases may be a valuable source for epidemiological research in hip fracture surgery, if the diagnoses are valid. We examined validity of and surgical procedure codes Danish Multidisciplinary Hip Fracture Registry (DMHFR) National Patient (DNPR) by calculating positive predictive value (PPV).We identified random sample 750 patients registered DMHFR between 2014 2017. Diagnoses have been coded 10th revision International Classification Diseases, while procedures Nordic...

Abstract Objective to develop a user-friendly prediction tool of 1-year mortality for patients with hip fracture, in order guide clinicians and on appropriate targeted preventive measures. Design population-based cohort study from 2011 2017 using nationwide data the Danish Hip Fracture Registry. Subjects total 28,791 age 65 above undergoing surgery first-time fracture. Methods patient-related prognostic factors at time admission were assessed as potential predictors: Nursing home residency,...

Toll-like receptor (TLR) agonists can reactivate HIV from latently infected cells in vitro. We aimed to investigate the TLR-9 agonist, CPG 7909's vivo effect on proviral reservoir and HIV-specific immunity. This was a post-hoc analysis of double-blind randomized controlled vaccine trial. HIV-infected adults were 1∶1 receive pneumococcal vaccines with or without 1 mg 7909 as adjuvant at 0, 3 9 months. In patients suppressive antiretroviral therapy we quantified DNA 3, 4, 9, 10 months (31...

We examined whether the comorbidity burden of patients with hip fracture was associated quality in-hospital care reflected by fulfillment process performance measures.Population-based cohort study using prospectively collected data from Danish Multidisciplinary Hip Fracture Registry (DMHFR).Patients aged 65 years or older an incident 2014 to 2018 registered in DMHFR (n = 31,443).Comorbidity measured Charlson Comorbidity Index based on hospital diagnoses. Quality defined as eligible measures,...

Purpose: It remains uncertain how a history of stroke impacts the prognosis for patients with hip fracture. This study aimed to evaluate mortality following fracture surgery by comparing and without stroke. Patients Methods: All aged 65 years or above in Denmark receiving between 2010 2018. For every patient, 10 individuals from general population were sampled. Comparators had similar history, age, sex on date (index date). We established four cohorts: with/without non-hip Outcomes all-cause...

Comorbidity has an important role in risk prediction and adjustment modelling observational studies. However, it is unknown which comorbidity index most accurate to predict mortality hip fracture patients. We aimed evaluate the ability, including discrimination calibration of Charlson (CCI), Elixhauser (ECI) Rx-risk for 30 day- 1 year a population-based cohort surgery patients.Using Danish Multidisciplinary Hip Fracture Registry period 2014-2018, 31,443 patients were included. CCI ECI based...

The aim of this study was to investigate the association between Parkinson's disease (PD) and postoperative complications, mortality, quality in-hospital care in patients with hip fracture.We included aged 65+ years an incident fracture from 2004-2017, registered Danish Multidisciplinary Hip Fracture Registry. Patients PD were identified using diagnosis codes prior fracture. Using log-binomial regression, we calculated both 30-day crude adjusted risk ratios (aRR) 95% confidence intervals...

Background and Purpose: Patients with hip fractures often have comorbidities, but detailed data on comorbidity its impact prognosis are lacking. We described the current trends in prevalence of magnitude associated mortality. Methods: From Danish Multidisciplinary Hip Fracture Registry we included 31,443 fracture patients (diagnosed 2014– 2018). calculated individual diseases measured Charlson Comorbidity Index (CCI), Elixhauser Index, Rx-Risk Index. sex age-adjusted odds ratios (aORs) for...

Patients undergoing hip fracture surgery have a 10 times increased risk of stroke compared with the general population. We aimed to evaluate association between CHA2 DS2 -VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke/TIA [transient ischemic attack]/systemic embolism (2 points), vascular disease, 65-74 and female sex) score stroke, thromboembolism, all-cause mortality in patients or without atrial fibrillation (AF).Nationwide prospective cohort...

Anticholinergic (AC) drugs are associated with various determinantal outcomes. Data regarding the effect of AC on mortality among geriatric hip fracture patients limited and inconsistent.Using Danish health registries, we identified 31,443 aged ≥65 years undergoing surgery. burden was assessed 90 days before surgery by Cognitive Burden (ACB) score number drugs. Logistic Cox regression producing odds ratios (OR) hazard (HR) for 30- 365- day mortality, adjusting age, sex, comorbidities were...

ABSTRACT Considerable uncertainty prevails regarding risk factors for recurrent fracture among older patients with hip fracture. We aimed to investigate the relationship between prefracture stroke history, baseline mobility, and of This cohort study was based on Danish Multidisciplinary Hip Fracture Registry, 2011–2018 (n = 48,230). estimated cumulative incidence (competing death) major osteoporotic fractures within 1 2 years comparing with/without history. Analyses were performed overall...

Benign prostatic hyperplasia comprises a significant burden to ageing men due frequently associated lower urinary tract symptoms and the risk of developing serious complications, such as acute retention. Healthcare databases are valuable source epidemiological research; however, continuous validation definitions is imperative. We examined positive predictive values International Classification Diseases, 10th Revision (ICD-10), diagnostic coding for benign retention in Danish National Patient...

Objectives Risk of infections in patients with solid cancers and bone metastases (BM) the subsequent impact on prognosis is unclear. We examined risk among cancer diagnosed BM mortality. Design Population-based cohort study. Setting Danish medical databases holding information all hospital contacts Denmark. Participants Adult between 1 January 1994 30 November 2013. Outcome measures In analyses, outcome was time to hospitalisation for common severe infections, pneumonia, sepsis urinary tract...

<h3>Introduction</h3> Older patients with frailty are vulnerable to hospitalisation and transitional care due limited intrinsic resources overcome stressors.¹ Thus, specialized interdisciplinary cross-sectoral approaches needed provide high-quality care. Despite well-documented interventions, healthcare systems still struggle fulfil patients' needs. To address deficiencies, a national clinical database is being established monitor variation in The Danish Clinical Quality Program...

Purpose: Anticholinergic (AC) drugs are known to cause several adverse effects. The problem may be even greater among patients with hip fracture.Methods: Using Danish health registries, we identified 31,443 aged ≥65 years undergoing fracture surgery. AC burden was assessed by the Cognitive Burden (ACB) score and number of drugs. logistic Cox regression computed odds ratios (OR) hazard (HR) for 30- 365- day mortality, adjusting age, sex, comorbidities.Results: were redeemed 24% 0-3 months...