A5022557620- Myasthenia Gravis and Thymoma
- Parkinson's Disease and Spinal Disorders
- Peripheral Neuropathies and Disorders
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Antifungal resistance and susceptibility
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- E-Learning and Knowledge Management
- Dementia and Cognitive Impairment Research
- Thyroid and Parathyroid Surgery
- Cancer Treatment and Pharmacology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Neurological Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Childhood Cancer Survivors' Quality of Life
Charité - Universitätsmedizin Berlin
2023-2025
Freie Universität Berlin
2023-2025
Humboldt-Universität zu Berlin
2023-2025
Humboldt State University
2024
University of Lübeck
2022-2023
German Center for Neurodegenerative Diseases
2020
University of Rostock
2020
Background Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions, leading to fluctuating muscle weakness. While many patients respond well standard immunosuppression, a substantial subgroup faces ongoing disease activity. Emerging treatments such as complement factor C5 inhibition (C5IT) and neonatal Fc receptor (FcRn) antagonism hold promise for these patients. However, the current landscape hindered by paucity of comparative data that crucial treatment...
Biologics that target pathogenic antibodies (Abs) and their effector functions such as the complement inhibitor ravulizumab neonatal Fc receptor agonist efgartigimod have recently been approved for treatment of acetylcholine (AChR)-Ab-positive myasthenia gravis (MG), but comparative studies are lacking.
Abstract Myasthenia gravis (MG) is a neuromuscular disorder resulting in exertion-dependent muscle fatigability. Affecting all age groups MG chronic disease with unpredictable fluctuations and range of symptom expression which can require costly immunosuppressive therapy intensive care critically influencing economic burden. Here we aim to elucidate both the personal societal burden MG. Data were used from two sources: (1) cross sectional study patients registered German Society (DMG)...
Myasthenia gravis (MG) is an autoimmune disorder primarily caused by autoantibodies against the acetylcholine receptor (AChR). Approximately 15% of MG patients, categorized as seronegative (snMG), lack detectable antibodies. Due to snMG status, there may be a diagnostic delay. Moreover, are limited data on treatment response in comparison AChR-Ab+ patients. This study examines burden disease, response, and quality life patients AChR-ab+ healthy controls. A questionnaire-based survey was...
Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for investigation cBF changes in-vivo. In this study we assessed alterations functional connectivity (FC), mean diffusivity (MD), and volume across spectrum AD. We further effects amyloid pathology on these changes. Participants included healthy controls, subjects subjective (SCD), mild impairment (MCI), or AD dementia (ADD) from multicenter DELCODE...
Background Myasthenia gravis (MG) is a rare autoimmune disease characterized by fatigable weakness of the voluntary muscles and can exacerbate to life-threatening myasthenic crisis (MC), requiring intensive care treatment. Routine laboratory parameters are cost-effective widely available method for estimating clinical outcomes several diseases, but so far, such have not been established detect progression in MG. Methods We conducted retrospective analysis selected related inflammation...
Abstract Purpose Myasthenia gravis (MG) is a rare, potentially life-threatening autoimmune disease with fluctuating muscle weakness frequently affecting women of childbearing age. MG can affect maternal as well neonatal outcome risk worsening myasthenic symptoms in the mothers and transient myasthenia (TNMG) arthrogryposis multiplex congenita (AMC) or foetal acetylcholine receptor antibody-associated disorders (FARAD) neonates. Methods Retrospective analysis cohort pregnant patients treated...
Einleitung: Neue Strategien zur Behandlung der Myasthenia gravis (MG) umfassen die Inhibition des Komplementfaktors C5 (C5IT) sowie den Antagonismus neonatalen Fc-Rezeptors (FcRn) und stellen vielversprechende Optionen für hochaktive Verläufe dar. Bisher verfügbare indirekte Vergleiche dieser Therapiemechanismen ergaben heterogene Resultate. Ziel Studie ist daher ein direkter Vergleich in einem Real World-Setting.
There is a growing demand for reliable biomarkers to monitor disease progression in Amyotrophic Lateral Sclerosis (ALS) that also take the heterogeneity of ALS into account. In this study, we explored association between Magnetic Resonance Imaging (MRI)-derived measures cortical thickness (CT) and subcortical grey matter (GM) volume with D50 model parameters. T1-weighted MRI images 72 Healthy Controls (HC) 100 patients were analyzed using Surface-based Morphometry structures Voxel-based...
<title>Abstract</title> Background and Aims: Recent years have seen a rapid growth in the number of online health communities targeted at patients with long-term conditions. Myasthenia Gravis (MG) is rare neurological disease for which such not been analysed before. The aim this study was to better understand needs MG population through collation categorisation questions that users social media were asking fellow on these platforms. Methodology: Systematic observation four Facebook groups...
Abstract Background Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune-mediated neuromuscular disorder leading to muscle weakness, autonomic dysregulation and hyporeflexia. Psychosocial well-being affected. Previously, we assessed burden of disease for Myasthenia gravis (MG). Here, aim elucidate by comparing health-related quality life (HRQoL) patients with LEMS the general population (genP) as well MG patients. Methods A questionnaire-based survey included sociodemographic clinical...
<sec> <title>BACKGROUND</title> Myasthenia gravis (MG) is rare, chronic autoimmune disorder of the neuromuscular junction that requires specialized care and often life-long treatment, facing challenges due to its rarity limited availability specialists. Telemedical solutions in centers hold considerable promise bridging this gap by increasing access a broader patient population timely manner. However, there no research regarding interventional remote field MG date. </sec>...
Rationale: Myasthenia gravis (MG) is a rare, chronic neurological disorder leading to fluctuating muscle weakness and potentially life-threatening crises. Patients often require life-long specialized treatment, but timely interventions are frequently hindered by the limited availability of specialists. Telemedical solutions at centers enabling patient-physician interaction hold promise in bridging this gap, not yet available for MG. We developed 'MyaLink,' remote monitoring platform tailored...
Myasthenia gravis (MG) is a rare, chronic neurological disorder leading to fluctuating muscle weakness and potentially life-threatening crises. Patients often require life-long specialized treatment, but timely interventions are frequently hindered by the limited availability of specialists. Telemedical solutions at centers enabling patient-physician interaction hold promise in bridging this gap, not yet available for MG. We developed 'MyaLink,' remote monitoring platform tailored MG,...
Myasthenia gravis (MG) is rare, chronic autoimmune disorder of the neuromuscular junction that requires specialized care and often lifelong treatment, facing challenges due to its rarity limited availability specialists. Telemedical solutions in centers hold considerable promise bridging this gap by increasing access a broader patient population timely manner. However, there no research regarding interventional remote field MG date. This study aimed assess feasibility usability among...
The neurophysiological technique motor unit number index (MUNIX) is increasingly used in clinical trials to measure loss of units. However, the heterogeneous disease course amyotrophic lateral sclerosis (ALS) obfuscates robust correlations between status and electrophysiological assessments. To address this heterogeneity, MUNIX was applied D50 progression model by analyzing aggressiveness (D50) accumulation (rD50 phase) ALS separately. 237 patients, 45 controls 22 ALS-Mimics received...
Background Myasthenia gravis (MG) is a rare autoimmune disease and chronic condition that necessitates specialized care. Patients experience significant burden of affecting various aspects their lives. The aim this study was to investigate the impact MG on family planning, challenges associated with pregnancy, childcare responsibilities extent which patients perceive utilize social support. Methods This analysis used data from our main large cross-sectional built questionnaire-based survey...
ABSTRACT Background Myasthenia gravis (MG) is a rare autoimmune disease characterized by fatigable weakness of the voluntary muscles and can exacerbate to life-threatening myasthenic crisis (MC), requiring intensive care treatment. Routine laboratory parameters are cost-effective widely available method for estimating clinical outcomes several diseases, but so far such have not been established detect progression in MG. Methods We conducted retrospective analysis selected related...
Die Myasthenia gravis wird durch eine autoantikörpervermittelte Übertragungsstörung an der neuromuskulären Endplatte hervorgerufen. Leitsymptom ist belastungsabhängige Muskelschwäche. Diagnostisch haben Nachweis von typischen Autoantikörpern und die elektrophysiologische Untersuchung einen hohen Stellenwert. Symptomatische immunmodulierende medikamentöse Therapien stehen zur Verfügung, für bestimmte Patienten auch Thymektomie. Prognose myasthene Krisen bestimmt, mit einer erhöhten Mortalität...
Recent years have seen a rapid growth in the number of online health communities targeted at patients with long-term conditions. Myasthenia Gravis (MG) is rare neurological disease for which such not been analysed before. The aim this study was to better understand needs MG population through collation and categorisation questions that users social media were asking fellow on these platforms.
Abstract Purpose: Myasthenia gravis (MG) is a rare, potentially life-threatening autoimmune disease with fluctuating muscle weakness frequently affecting women of childbearing age. MG can affect maternal as well neonatal outcome risk worsening myasthenic symptoms in the mothers and transient myasthenia (TNMG) arthrogryposis multiplex congenita (AMC) or fetal acetylcholine receptor antibody-associated disorders (FARAD) neonates. Methods: Retrospective analysis cohort pregnant patients treated...