A5067519739- Lipid metabolism and biosynthesis
- Research Data Management Practices
- Data Quality and Management
- Genetics, Bioinformatics, and Biomedical Research
- Scientific Computing and Data Management
- Adipose Tissue and Metabolism
- Big Data and Business Intelligence
- Endoplasmic Reticulum Stress and Disease
- Big Data Technologies and Applications
- Medical Research and Treatments
- Microbial Metabolic Engineering and Bioproduction
- Pancreatic function and diabetes
- Photosynthetic Processes and Mechanisms
- Library Science and Information Literacy
- Plant Virus Research Studies
- Machine Learning and Data Classification
- Meta-analysis and systematic reviews
- Wikis in Education and Collaboration
- Lysosomal Storage Disorders Research
- Educational Strategies and Epistemologies
- Expert finding and Q&A systems
- Air Quality and Health Impacts
- Cell Image Analysis Techniques
- Sulfur Compounds in Biology
- Fiscal Policy and Economic Growth
Jiaxing University
2024
Guangzhou Automobile Group (China)
2023
Carnegie Mellon University
2016-2022
Southeast University
2021
Yale University
2013-2020
University of Chinese Academy of Sciences
2018
Harvard University
2016-2017
Boston University
2016
Hospital for Sick Children
2011-2012
University of Toronto
2011
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using Drosophila and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step formation—the conversion small, nascent LDs to larger, mature LDs. Seipin forms dynamic foci interact with enable their growth. In absence numerous accumulate near most often fail grow. Those do grow prematurely acquire synthesis enzymes undergo expansion, eventually leading...
Lipid droplets (LDs) form from the endoplasmic reticulum (ER) and grow in size by obtaining triacylglycerols (TG). Triacylglycerol hydrolase (TGH), a lipase residing ER, is involved mobilization of TG stored LDs for secretion very-low-density lipoproteins. In this study, we investigated TGH-mediated changes cytosolic LD dynamics. We have found that TGH deficiency resulted decreased increased number hepatocytes. Using fluorescent fatty acid analogues to trace formation, observed did not...
The assembly of very low density lipoproteins involves the formation a primordial, poorly lipidated apoB-containing particle in endoplasmic reticulum, followed by addition neutral lipid from luminal droplets (LLD). However, and protein compositions LLD have not been determined. We isolated mouse liver microsomes analyzed their compositions. are variably sized particles relatively poor triacylglycerol (TG) content when compared with composition cytosolic (CLD). They devoid apoB, adipophilin,...
Abstract Induction of endoplasmic reticulum (ER) stress was previously shown to impair hepatic apolipoprotein B100 (apoB) production by enhancing cotranslational and posttranslational degradation newly synthesized apoB. Here, we report the involvement autophagy in ER stress–induced apoB provide evidence for a significant role regulating biogenesis primary hepatocyte systems. following short-term glucosamine treatment McA-RH7777 cells resulted significantly increased colocalization with green...
Deleterious mutations in the serine lipase DDHD2 are a causative basis of complex hereditary spastic paraplegia (HSP, subtype SPG54) humans. We recently found that is principal triglyceride hydrolase central nervous system (CNS) and genetic deletion this enzyme mice leads to ectopic lipid droplet (LD) accumulation neurons throughout brain. Nonetheless, how HSP-related relate metabolism LD formation remains poorly understood. Here, we have characterized set they disrupt activity vitro impair...
Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1α and -1β, localized at different subcellular compartments. A third isoform, lipin-1γ was recently cloned its localization is unknown. Here, we demonstrate that lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1γ-specific domain. Additional expression of altered LD morphology without affecting triacylglycerol...
ABSTRACT Chat reference service has been used in academic libraries to more efficiently serve patrons the digital age. Identifying question topics on chat can help librarians understand patrons' needs and improve services. Researchers have qualitative methods types records; however, these are inefficient analyze large datasets. Here, we conducted a novel research using Latent Dirichlet Allocation (LDA) topic modeling automatically extract from transcripts generated 5 years university...
Compared to basic fork-join queues, a job in (n, k) queues only needs its k out of all n sub-tasks be finished. Since are prevalent popular distributed systems, erasure coding based cloud storages, and modern network protocols like multipath routing, estimating the sojourn time such is thus critical for performance measurement resource plan computer clusters. However, keeps well-known open challenge years, rough bounds limited range load factors have been given. In this paper, we developed...
<ns3:p>As research becomes more interdisciplinary, fast-paced, data-intensive, and collaborative, there is an increasing need to share data other products in accordance with Open Science principles. In response this need, we created & Data Collaborations (OSDC) program at the Carnegie Mellon University Libraries that provides tools, training, collaboration opportunities, community-building events support Research adoption. This presents a unique end-to-end model for programs because it...
The ACRL Framework for Information Literacy presents opportunities moving beyond ‘one-shot’ information literacy sessions and creating a more scaffolded embedded approach instruction. We collaborated with faculty at Carnegie Mellon University to create Framework-inspired learning objectives first-year third-year science undergraduates are continuously refining the as curriculum continues evolve. This article describes our objective design refinement process, challenges encountered, ideas on...
<ns4:p>As research becomes more interdisciplinary, fast-paced, data-intensive, and collaborative, there is an increasing need to share data other products in accordance with Open Science principles. In response this need, we created & Data Collaborations (OSDC) program at the Carnegie Mellon University Libraries that provides tools, training, collaboration opportunities, community-building events support Research adoption. This presents a unique end-to-end model for programs because it...
Slides from panel session on Artificial Intelligence and Machine Learning at NISO Plus 2020Session description: With more information providers exploring the implications of AI machine learning for their businesses services, this is a timely discussion issues we need to be considering now in order ensure that make right decisions future.
The proportion of highways in infrastructure investment is growing and playing a significant role. It has many advantages all aspects social life become timely subject recent research. However, the existing literature lacks systematic review current research status highway investment. Thus, this study aims to conduct scientometric analysis on provide an overview its state Using Web Science Core Collection database, conducted searches screenings 614 documents related from 2013 2023....
Suppression of MEK/ERK signalling in HepG2 cells promotes the assembly and secretion VLDL-sized apoB100-containing lipoproteins via an unknown mechanism (Tsai et al, Arterioscler Thromb Vasc Biol 2007; 27:211-218). In this report, we investigated mechanisms underlying profound stimulatory effects inhibition on VLDL cells. Following with inhibitor U0126, mRNA levels lipin-1α, -1β, apoCIII CideB were significantly increased by 1.22, 1.25, 3.6, 1.9 fold, respectively, all key factors involved...