A5000223106- Connexins and lens biology
- Nicotinic Acetylcholine Receptors Study
- Heat shock proteins research
- Ion channel regulation and function
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Biotin and Related Studies
- Liver Diseases and Immunity
- Clinical Nutrition and Gastroenterology
- Advanced Proteomics Techniques and Applications
- Hepatitis B Virus Studies
- FOXO transcription factor regulation
- Yersinia bacterium, plague, ectoparasites research
- Cellular transport and secretion
Cornell University
2020-2023
Weill Cornell Medicine
2023
University of Nebraska Medical Center
2014-2021
Nebraska Medical Center
2014
Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) with portal inflammation and ductular reaction. Based on reports biliary damage, as well increased circulating free acids (FFAs) in NAFLD, we hypothesized the involvement cholangiocyte lipoapoptosis mechanism cellular injury. Here, demonstrate that saturated FFAs palmitate stearate induced robust rapid cell death cholangiocytes. Palmitate concentration-dependent manner multiple...
ABSTRACT Regulation of glucose transport, which is central for control whole-body metabolism, determined by the amount GLUT4 transporter (also known as SLC2A4) in plasma membrane (PM) fat and muscle cells. Physiologic signals [such activated insulin receptor or AMP-activated protein kinase (AMPK)] increase PM GLUT4. Here, we show that distribution between interior human cells dynamically maintained, AMPK promotes redistribution regulating exocytosis endocytosis. Stimulation mediated Rab10...
1α-25(OH)2 vitamin D3 (1-25D), an active hormonal form of Vitamin D3, is a well-known chemopreventive and pro-differentiating agent. It has been shown to inhibit the growth several prostate cancer cell lines. Gap junctions, formed proteins called connexins (Cx), are ensembles cell-cell channels, which permit exchange small regulatory molecules between adjoining cells. Cell-cell communication mediated by gap junctional channels important homeostatic control mechanism for regulating...
Defects in assembly of gap junction-forming proteins, called connexins (Cxs), are observed a variety cancers. Connexin32 (Cx32; also known as GJB1) is expressed by the polarized cells epithelia. We discovered two dileucine-based motifs, which govern intracellular sorting and endocytosis transmembrane C-terminal tail Cx32 explored their role regulating its abilities pancreatic prostate cancer cells. One motif, designated LI, was located near juxtamembrane domain, whereas other, LL, distally....
Abstract Regulation of glucose transport into muscle and adipocytes, central for control whole-body metabolism, is determined by the amount GLUT4 transporter in plasma membrane ( PM ). Physiologic signals (activated insulin receptor or AMP kinase [ AMPK ]), acutely increase to enhance uptake. Here we show kinetic studies that intracellular equilibrium with unstimulated cultured human skeletal cells, promotes redistribution regulating both exocytosis endocytosis. AMPK-stimulation requires...
ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Anuttoma Ray author on ‘Dileucine-like motifs C-terminal tail connexin32 control its endocytosis and assembly into gap junctions’, Science. PhD student lab Dr Parmender P. Mehta at University Nebraska Medical Center, Omaha, USA, investigating molecular mechanisms that regulate connexins junctions.
ABSTRACT Gap junctions (GJ)s are formed by the assembly of constituent transmembrane proteins called connexins (Cxs). Aberrations in this Cxs observed several genetic diseases as well cancers. Hence it becomes imperative to understand molecular mechanisms underlying such defect. The polarized cells epithelia express Connexin32 (Cx32). carboxyl-terminal tail (CT) Cx32 orchestrates aspects GJ dynamics, function and growth. study here was aimed at determining if post-translational...