A5066628570- Metabolomics and Mass Spectrometry Studies
- Spectroscopy and Chemometric Analyses
- Trace Elements in Health
- Diet and metabolism studies
- Heavy Metal Exposure and Toxicity
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Plant Micronutrient Interactions and Effects
- Iron Metabolism and Disorders
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gene expression and cancer classification
- Alcoholism and Thiamine Deficiency
- Genomics, phytochemicals, and oxidative stress
- Liver Disease and Transplantation
- Parkinson's Disease Mechanisms and Treatments
- Microbial Natural Products and Biosynthesis
- Microbial Metabolism and Applications
- Computational Drug Discovery Methods
- High Altitude and Hypoxia
- Advanced Proteomics Techniques and Applications
- Bone health and osteoporosis research
- Sulfur Compounds in Biology
- Muscle metabolism and nutrition
Centre de Recherche en Nutrition Humaine d'Auvergne
2007-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2005-2024
Unité de Nutrition Humaine
2015-2024
Université Clermont Auvergne
2005-2023
Metabo (Switzerland)
2020
MetaboHUB
2019
Centre de Recherche en Nutrition Humaine Rhône-Alpes
2005-2013
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2005-2006
University College Cork
2005
Institut National de la Recherche Agronomique du Niger
2005
Chronic bilateral subthalamic stimulation leads to a spectacular clinical improvement in patients with motor complications. However, the post-operative body weight gain involved may limit benefits of surgery and induce critical metabolic disorders. Twenty-four Parkinsonians (61.1 ± 1.4 years) were examined 1 month before (M − 1) 3 months after + 3) surgery. Body composition energy expenditure (EE) measured (1) over 36 h calorimetric chambers (CC) rigorous control food intakes activities...
Increased postmenopausal bone turnover leads to loss and fragility fracture risk. In the absence of osteoporosis, risk preventive measures, particularly those modifying nutritional lifestyle, are appropriate. We tested hypothesis that milk supplementation affects related biochemical markers in a direction that, long term, may be expected reduce loss. Thirty healthy women aged 59.3 (SD 3.3) years were enrolled prospective crossover trial 16 weeks. After 4-week period adaptation with diet...
BackgroundMetabolic syndrome (MetS), a cluster of factors associated with risks developing cardiovascular diseases, is public health concern because its growing prevalence. Considering the combination concomitant components, their development and severity, MetS phenotypes are largely heterogeneous, inducing disparity in diagnosis.MethodsA case/control study was designed within NuAge longitudinal cohort on aging. From 3-year follow-up 123 stable individuals, we present deep phenotyping...
Patient stratification, prediction, prevention and prognosis
Oxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly on cytokines. Here, using a standardized whole-blood stimulation system, we characterized the oxylipin-driven inflammatory responses to various stimuli and their relationships with cytokine responses. We performed pilot study in 25 healthy individuals 6 different stimuli: 2 bacterial (LPS live BCG), viral (vaccine-grade poly I:C H1N1 attenuated influenza), an enterotoxin superantigen Null control. All...
Abstract Genes are pleiotropic and getting a better knowledge of their function requires comprehensive characterization mutants. Here, we generated multi-level data combining phenomic, proteomic metabolomic acquisitions from plasma liver tissues two C57BL/6 N mouse models lacking the Lat (linker for activation T cells) Mx2 (MX dynamin-like GTPase 2) genes, respectively. Our dataset consists 9 assays (1 preclinical, 2 proteomics 6 metabolomics) with fully non-targeted standardized approach....
Zn has been shown to possess antioxidant properties in vitro and . As inadequate dietary intake reported these populations, supplementation may protect against oxidative stress thereby limit the progression of degenerative diseases such populations. We conducted present study evaluate long-term effects two moderate doses on Cu-induced LDL oxidation French men women.Three groups sixteen healthy subjects aged 55–70 years from each sex participated this randomized double-blind,...
Marine fungi have been found in all habitats and are able to adapt their environmental niche conditions. In this study, a combination of liquid chromatography coupled high-resolution mass spectrometry (LC-HRMS) gas (GC-MS) analytical approaches was used analyse the metabolic changes marine-sourced Penicillium restrictum strain isolated from marine shellfish area. The P. MMS417 grown on seven different media including an ecological one with two water sources (synthetic seawater distilled...
In nutrition and health research, untargeted metabolomics is actually analyzed simultaneously with clinical data to improve prediction better understand pathological status. This can be modeled using a multiblock supervised model several input blocks (metabolomics, data) being potential predictors of the outcome explained. Alternatively, this configuration represented path diagram where are each connected by links directed outcome—as in modeling—and also related other, thus allowing one...