A5019584569- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Pesticide Residue Analysis and Safety
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- High voltage insulation and dielectric phenomena
- Epigenetics and DNA Methylation
- Bioactive natural compounds
- Cancer-related molecular mechanisms research
- Power Transformer Diagnostics and Insulation
- Ginseng Biological Effects and Applications
- Breast Lesions and Carcinomas
- Date Palm Research Studies
- Smart Agriculture and AI
- Multiple and Secondary Primary Cancers
- Genetics, Aging, and Longevity in Model Organisms
- Ferroptosis and cancer prognosis
- Environmental and Analytical Chemistry Studies
- High-Voltage Power Transmission Systems
- Digital Radiography and Breast Imaging
- ATP Synthase and ATPases Research
- Model Reduction and Neural Networks
- Reinforcement Learning in Robotics
- Morinda citrifolia extract uses
Hainan University
2020-2025
Nanjing Chest Hospital
2024
Guangzhou University of Chinese Medicine
2017-2024
Nanjing Medical University
2024
Nanjing Brain Hospital
2024
University of Notre Dame
2022
South China Agricultural University
2021
The University of Tokyo
2017-2018
China Southern Power Grid (China)
2018
South China University of Technology
2017
Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that fraction the synthesized is routed to pathway for ATP production. The composed by reactions synthesis, one-carbon (folate) and glycine cleavage system (SOG pathway). Here we show SOG upregulated at level gene expression in subset human tumors its correlates with signatures proliferation Myc target activation. also estimated metabolic flux NCI60...
Abstract Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are required for deciphering genetic code accurately, as well stabilizing tRNA. Loss tRNA frequently results severe pathological consequences. Here, we perform a comprehensive...
It has been generally thought that tRNA modifications are stable and static, their frequencies rarely regulated. N6-threonylcarbamoyladenosine (t6A) occurs at position 37 of five mitochondrial (mt-)tRNA species. We show YRDC OSGEPL1 responsible for t6A37 formation, utilizing L-threonine, ATP, CO2/bicarbonate as substrates. OSGEPL1-knockout cells exhibit respiratory defects reduced translation. find low level in mutant mt-tRNA isolated from the MERRF-like patient's cells, indicating lack...
Post-transcriptional modifications affect tRNA biology and are closely associated with human diseases. However, progress on the functional analysis of in metazoans has been slow because difficulty identifying modifying enzymes. For example, biogenesis function prevalent N2-methylguanosine (m2G) at sixth position tRNAs eukaryotes long remained enigmatic. Herein, using a reverse genetics approach coupled RNA-mass spectrometry, we identified that THUMP domain-containing protein 3 (THUMPD3) is...
Methyltransferase-like 8 (METTL8) encodes a mitochondria-localized METTL8-Iso1 and nucleolus-distributed METTL8-Iso4 isoform, which differ only in their N-terminal extension (N-extension), by mRNA alternative splicing. generates 3-methylcytidine at position 32 (m3C32) of mitochondrial tRNAThr tRNASer(UCN). Whether is an active m3C32 methyltransferase the role N-extension tRNA formation remain unclear. Here, we revealed that was inactive generation due to lack N-extension, contains several...
Morinda officinalis is beneficial for the treatment of inflammatory bowel disease (IBD). The hairy root with higher genetic and biochemical stability cultured from M. might have similar effects to treat IBD. In this study, main chemical composition extracts (MORE) native plant extract (MOHRE) was compared by quantitative HPLC. difference their therapeutic potential mechanism evaluated using 3% dextran sodium sulfate-induced chronic colitis in mice T lymphocytes vitro. results found that...
The accurate detection of green citrus in natural environments is a key step realizing the intelligent harvesting through robotics. At present, visual algorithms for still have poor accuracy and robustness due to color similarity between fruits backgrounds. This study proposed multi-scale convolutional neural network (CNN) named YOLO BP detect environments. Firstly, backbone network, CSPDarknet53, was trimmed extract high-quality features improve real-time performance network. Then, by...
Adiponectin physically interacts with by comigration in gel electrophoresis (View Interaction 1, 2) cosedimentation through density gradient interaction)
BACKGROUND. China has faced barriers to implementation of a population-based mammographic screening program. Breast ultrasound provides an alternative modality mammography in low-resource settings. OBJECTIVE. The purpose this study was evaluate the performance automated breast (ABUS) with remote reading as primary for cancer. METHODS. This prospective enrolled asymptomatic women 35-69 years old from 46 community health centers across 18 provinces representing all six regions January 2021...
The oil palm (Elaeis guineensis) is a crucial agricultural commodity, yielding the highest output among oil-bearing crops. Despite its significance, productivity challenges persist due to genetic and environmental factors. This study breaks new ground by mapping tRNA modifications in palm, exploring their roles during fruit ripening, an area not extensively studied non-model Utilizing advanced RNA mass spectrometry techniques, we identified 48 distinct across 88 sites, alongside 164 genes...
Abstract Neonicotinoids (NEOs), highly selective toward insect nicotinic acetylcholine receptors, are extensively used due to their effectiveness against pests and relative non‐toxicity vertebrates. However, prolonged persistence in soil water has led frequent detection food environmental samples, posing significant health concerns. Recent research indicates these pesticides infiltrate aquatic ecosystems, threatening life human health. Here, we improved the ultra‐performance liquid...
Abstract Background With a considerable variety of cancer subtypes, Non-small cell lung (NSCLC) poses substantial threat to public health, affecting large number individuals and resulting in high mortality rate. Circular RNA (circRNA) has been applied various diseases, including cancers. This study aims investigate the clinial significance functional role circPTP4A2 NSCLC. Methods The serum tissue samples were collected for detecting expression NSCLC using reverse transcription-quantitative...
This paper proposes a novel fault interpretation method for transformer winding using features extracted from equivalent gradient areas of frequency responses. Firstly, responses are pre-processed binary morphology, aiming to eliminate the influence stochastic factors such as noises and measurement configurations. Then curves divided into several sub-bands, each which reflects faults. based on derived quantify shape variations response with respect specific types. Finally, real case studies...
Frequency response analysis (FRA) demonstrates significant advantages in the diagnosis of transformer winding faults. The instrument market desires intelligent diagnostic functions to ensure that FRA technique is more practically useful. In this paper, a hierarchical dimension reduction (HDR) classifier proposed identify types typical incipient procedure hierarchical. First, measured frequency (FR) curves are preprocessed using binarization and binary erosion normalize FR data. Second,...
Post-transcriptional modification of nucleosides is observed in almost all elements RNA. Modified finely tune the structure RNA molecules and affect vital functions, such as modified wobble position 34 transfer RNAs expanding reading preference anticodons to codons. Recent investigations have revealed that species their frequencies an element are not stable but vary with specific cellular factors including metabolites particular proteins (writers, readers, erasers). To understand link...
摘要: 采用QuEChERS方法结合气相色谱-串联质谱法(GC-MS/MS)建立了蔬菜、水果中129种农药残留同时检测的分析方法。试样用1%乙酸乙腈均质提取,采用混合型固相分散萃取剂净化后,用GC-MS/MS在多反应离子监测(MRM)模式下进行检测,外标法定量。结果表明,129种药物在一定的含量范围内线性关系良好,相关系数(r2)均大于0.98;不同基质在10 μg/kg添加水平下大部分农药的平均回收率为66.2%~124.7%,相对标准偏差(RSD)为0.9%~24.4%;方法的定量限(LOQ)为0.03~16.7 μg/kg。结果表明,该方法简便快速、灵敏可靠、经济有效,适用于蔬菜、水果中农药多残留的同时快速筛查测定。
The coconut (