A5070638714- Peatlands and Wetlands Ecology
- Microbial Community Ecology and Physiology
- Cancer, Hypoxia, and Metabolism
- Botany and Plant Ecology Studies
- Metabolomics and Mass Spectrometry Studies
- Coastal wetland ecosystem dynamics
- Bryophyte Studies and Records
- Pancreatic function and diabetes
- Climate change and permafrost
- Advanced Proteomics Techniques and Applications
- Soil Carbon and Nitrogen Dynamics
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Plant Parasitism and Resistance
- Soil and Land Suitability Analysis
- Forensic Toxicology and Drug Analysis
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Methane Hydrates and Related Phenomena
- Plant Stress Responses and Tolerance
- Analytical chemistry methods development
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
- bioluminescence and chemiluminescence research
- Plant responses to elevated CO2
University of Chicago
2023-2025
University of Arizona
2019-2023
Sharif University of Technology
2017
Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels how cope with such nutrition is critical understand metabolism underpinning cell biology. Previously, we performed quantitative metabolomics interstitial fluid (the local perfusate) murine pancreatic ductal adenocarcinoma (PDAC) tumors comprehensively characterize availability these tumors. Here, develop
Abstract Background Microbiomes are now recognized as the main drivers of ecosystem function ranging from oceans and soils to humans bioreactors. However, a grand challenge in microbiome science is characterize quantify chemical currencies organic matter (i.e., metabolites) that microbes respond alter. Critical this has been development Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), which drastically increased molecular characterization complex samples, but...
Abstract Sphagnum mosses dominate peatlands by employing harsh ecosystem tactics to prevent vascular plant growth and microbial degradation of these large carbon stores. Knowledge about ‐produced metabolites, their structure function, is important better understand the mechanisms, underlying this sequestration phenomenon in face climate variability. It currently unclear which compounds are responsible for inhibition organic matter decomposition mechanisms occurs. Metabolite profiling fallax...
Warming-induced permafrost thaw could enhance microbial decomposition of previously stored soil organic matter (SOM) to carbon dioxide (CO2) and methane (CH4), one the most significant potential feedbacks from terrestrial ecosystems atmosphere in a changing climate. The environmental parameters regulating microbe-organic interactions greenhouse gas (GHG) emissions peatlands are however still largely unknown. objective this work is understand controls on SOM degradation its impact GHG across...
Peatlands are among the largest natural sources of atmospheric methane (CH4 ) worldwide. Microbial processes play a key role in regulating CH4 emissions from peatland ecosystems, yet complex interplay between soil substrates and microbial communities controlling as function global change remains unclear. Herein, we performed an integrated analysis multi-omics data sets to provide comprehensive understanding molecular driving changes greenhouse gas (GHG) ecosystems with increasing temperature...
Abstract Nutrient stress represents a significant barrier for antitumor immunity, and tumor interstitial fluid (TIF) often contains metabolites that hinder immune function. However, it is difficult to isolate the effects of nutrient from other suppressive factors. Thus, we employed chemically-defined cell culture medium based on metabolomic profile TIF: Tumor Interstitial Fluid Medium (TIFM). Culture CD8 + T cells in TIFM limited expansion impaired effector functions upon restimulation,...
As direct mediators between plants and soil, roots play an important role in metabolic responses to environmental stresses such as drought, yet these are vastly uncharacterized on a plant-specific level, especially for co-occurring species. Here, we aim examine the effects of drought root profiles carbon allocation pathways three tropical rainforest species by combining cutting-edge metabolomic imaging technologies situ position-specific 13C-pyruvate root-labeling experiment. Further, washed...
ABSTRACT Background Microbiomes are now recognized as main drivers of ecosystem function ranging from the oceans and soils to humans bioreactors. However, a grand challenge in microbiome science is characterize quantify chemical currencies organic matter (i.e. metabolites) that microbes respond alter. Critical this has been development Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS), which drastically increased molecular characterization complex samples, but challenges...
Abstract Ovarian clear cell carcinoma (OCCC) is a chemoresistant subtype of ovarian cancer accounting for 5-12% all epithelial cases. Lipid metabolism has been reported to be involved in platinum resistance and ferroptosis induction various types. However, the metabolomic lipidomic landscape OCCC not characterized. To explore metabolic processes driving aggressive nature advanced OCCC, we carried out global profiling on 64 early samples, including tumors with corresponding metastases. Snap...
The Biosphere 2 (B2) is a large-scale research facility owned by the University of Arizona that comprises seven enclosed biomes. Among these Tropical Rainforest (TRF), where environmental factors such as temperature and rainfall are managed in order to simulate natural ecosystem. Controlling elements define biotic community provides opportunity use B2 model study effect climate change on carbon cycling GHG emissions. Large amounts stored tropical soils, proceeding form organic compounds...