Sumudu Rajakaruna

ORCID: 0000-0003-1836-3726
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About
Contact & Profiles
Research Areas
  • Gut microbiota and health
  • Probiotics and Fermented Foods
  • Food composition and properties
  • Diet and metabolism studies
  • Advanced Glycation End Products research
  • Microbial Community Ecology and Physiology
  • Helicobacter pylori-related gastroenterology studies
  • Garlic and Onion Studies
  • Plant Parasitism and Resistance
  • Metabolism and Genetic Disorders
  • MicroRNA in disease regulation
  • Gastric Cancer Management and Outcomes
  • Pomegranate: compositions and health benefits
  • Nutrition, Health and Food Behavior
  • Peatlands and Wetlands Ecology
  • Phytochemicals and Antioxidant Activities
  • Pediatric health and respiratory diseases
  • Esophageal Cancer Research and Treatment
  • Dietary Effects on Health
  • Protein Hydrolysis and Bioactive Peptides
  • Plant-Microbe Interactions and Immunity
  • Phytoestrogen effects and research
  • Biochemical and biochemical processes
  • Vitamin D Research Studies
  • Clostridium difficile and Clostridium perfringens research

Wright State University
2019-2025

University of Arizona
2023-2024

Melanoidins are the products of Maillard reaction between carbonyl and amino groups macromolecules readily formed in foods, especially during heat treatment. In this study we utilized three-stage Human Gut Simulator system to assess effect providing melanoidins extracted from either biscuits or bread crust human gut microbiota. Addition growth medium led statistically significant alterations microbial community composition, it increased short-chain fatty acid antioxidant production by The...

10.3390/microorganisms10071268 article EN cc-by Microorganisms 2022-06-22

Peatlands store vast amounts of carbon, with deep peat carbon remaining stable due to limited thermodynamic energy and transport. However, climate change-induced increases in labile inputs could destabilize these stores. Here, we combined DNA isotope probing isotope-assisted metabolomics employing a multi-platform approach investigate microbial dynamics driving degradation upon (e.g., glucose) amendment. Our findings highlight the vulnerability as glucose addition triggers breakdown older...

10.1038/s43247-024-01954-y article EN cc-by-nc-nd Communications Earth & Environment 2024-12-27

Dietary consumption of green asparagus has been associated with several health benefits. These beneficial properties are attributed to the presence many bioactive compounds in asparagus, including saponins, phenolics, flavonoids, as well dietary fiber mostly comprising fructans and inulins, which prebiotics capable supporting growth members gut microbiota. In this study, we used vitro Human Gut Simulator system assess fermentation oro-gastro-intestinally digested powder by human Microbial...

10.1039/d4fo03504f article EN Food & Function 2025-01-01

Barrett's esophagus (BE) is the precursor lesion and a major risk factor for esophageal adenocarcinoma (EAC). Although patients with BE undergo routine endoscopic surveillance, current screening methodologies have proven ineffective at identifying individuals of EAC. Since microRNAs (miRNAs) potential diagnostic prognostic value as disease biomarkers, we sought to identify an miRNA signature EAC.High-throughput sequencing miRNAs was performed on serum tissue biopsies from 31 identified...

10.14309/ctg.0000000000000125 article EN cc-by-nc-nd Clinical and Translational Gastroenterology 2020-01-01

Eggplant, garlic, and onion were each fried, grilled, or roasted, subjected to an in vitro digestion-fermentation process. Vegetable type had the largest effect on gut microbiota structure. Oonion supported a more beneficial community.

10.1039/d3fo04526a article EN Food & Function 2024-01-01

Evidence indicates that both vitamin D and the gut microbiome are involved in process of colon carcinogenesis. However, it is unclear what effects supplemental

10.1128/spectrum.00083-24 article EN cc-by Microbiology Spectrum 2024-08-27

Pomegranate is a fruit that grows abundantly in the Middle East and Africa. It rich polyphenols, sugars, fiber, vitamins, has long been associated traditional alternative medicine with numerous health benefits, including treatment of diarrhea gut inflammation. We assessed how regular daily intake fresh pomegranate can affect distal microbiota young healthy female students Egypt, region abundant production frequent occurrence dysbiosis. Interrogation structure based on sequencing 16S...

10.3390/microorganisms13020305 article EN cc-by Microorganisms 2025-01-30

Different modifications of the standard bread recipe have been proposed to improve its nutritional and health benefits. Here, we utilized in vitro Human Gut Simulator (HGS) assess fermentation one such artisan by human gut microbiota. Dried milled bread, composed almond flour, psyllium husks, flax seeds as three main ingredients, was first subjected an protocol designed mimic oro-gastro-intestinal digestion. The digest then supplied complex microbial communities, replacing typical Western...

10.3390/microorganisms12061189 article EN cc-by Microorganisms 2024-06-12

<abstract> <p>High-fat diets have been associated with lower gut and fecal abundances of genus <italic>Bifidobacterium</italic>. Here, we investigated whether commonly consumed dietary free fatty acids any detrimental effect on the growth <italic>B. adolescentis</italic>, bifidum</italic>, longum</italic>. We found that presence in medium inhibits <italic>Bifidobacterium</italic> species to a varying degree, capric (C10:0), oleic...

10.3934/microbiol.2022005 article EN cc-by AIMS Microbiology 2022-01-01

In this study we assessed the extent to which diet quality and eating habits affected composition of distal gut microbiota.Twenty six adult subjects from low-income communities with a recently established food hub were recruited, their fecal microbiota was analyzed via interrogation 16S rRNA gene.Among dietary biometric parameters recorded for each subject, age statistically significant contributor variability.While healthy body mass indices had no direct correlation between themselves, they...

10.25177/jfst.4.7.sc.569 article EN SDRP Journal of Food Science & Technology 2019-01-01
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