A5000908760- Epigenetics and DNA Methylation
- Advanced Proteomics Techniques and Applications
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- Impact of Technology on Adolescents
- Extracellular vesicles in disease
- Advanced Biosensing Techniques and Applications
- Cancer-related gene regulation
- Child Development and Digital Technology
- Eating Disorders and Behaviors
- Glycosylation and Glycoproteins Research
- Lung Cancer Treatments and Mutations
- Proteoglycans and glycosaminoglycans research
- Membrane Separation Technologies
- Protease and Inhibitor Mechanisms
- Mental Health Research Topics
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Wastewater Treatment and Nitrogen Removal
- Pancreatitis Pathology and Treatment
- Conducting polymers and applications
- Immunotherapy and Immune Responses
- Genomics and Phylogenetic Studies
Korea Institute of Science and Technology
2017-2024
University of Chicago
2024
Biomedical Research Institute
2020
Seoul Institute
2020
Government of the Republic of Korea
2020
Yonsei University
2017-2019
Activation state of synovial macrophages is significantly correlated with disease activity and severity rheumatoid arthritis (RA) provides valuable clues for RA treatment. Classically activated M1 in inflamed joints secrete high levels pro-inflammatory cytokines chemokines, resulting bone erosion cartilage degradation. Herein, we propose extracellular vesicle (EV)-guided situ macrophage reprogramming toward anti-inflammatory M2 as a novel treatment modality based on the immunotherapeutic...
Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment resistance. In particular, tumor-associated macrophages (TAMs), as the predominant infiltrated in a tumor, play pivotal role regulating microenvironment. As potential therapeutic strategy to counteract TAMs, here we explore an exosome-guided situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages....
We propose to use cRFP (common Repository of FBS Proteins) in the MS (mass spectrometry) raw data search cell secretomes. is a small supplementary sequence list highly abundant fetal bovine serum proteins added reference database use. The aim behind using prevent contaminant from being misidentified as other database, just we would cRAP Adventitious present either by accident or through unavoidable contacts proteins. expect it be widely used experiments where are obtained serum-free media...
Syndecans (SDCs) are transmembrane proteoglycans that involved in cell adhesion and communication. Specifically, SDC2 plays a key role tumorigenesis, metastasis, angiogenesis. Previously, we found rat is shed by matrix metalloproteinase-7 (MMP-7) colon cancer cells. Here, analyzed the susceptibility of to various MMPs. We ectodomain (ECD) fused C-terminal Fc region, which was expressed mammalian cells, cleaved more efficiently MMP-14 than MMP-7. Likewise, when anchored on surface HeLa...
Stress plays an important role in the pathophysiology of addictive disorders. The kynurenine (KYN) pathway involved neuroimmune and cognitive functions is activated under stress. However, neuroimmunological-neurocognitive mechanisms stress disorders are unclear still now. Ninety-nine young adults aged 18-35 years [alcohol use disorder (AUD), N = 30; Internet gaming (IGD), 34; healthy controls (HCs), 35] participated this study. levels, resilience, addiction severity, neurocognitive were...
Abstract Although biomarker candidates associated with psoriasis have been suggested, those for predicting the risk of cardiovascular disease (CVD) early in patients are lacking. We aimed to identify candidate biomarkers that can predict occurrence CVD patients. pursued quantitative proteomic analysis serum samples composed three groups: and without factors, healthy controls. Age/Sex-matched were selected labeled 16-plex tandem mass tag (TMT) analyzed using liquid chromatography-mass...
Background: Addictive use of the Internet and online games is a potential psychiatric disorder termed gaming (IGD). Altered microRNA (miRNA) expression profiles have been reported in blood brain tissue patients with certain disorders suggested as biomarkers. However, there no reports on miRNA IGD. Methods: To discover IGD-associated miRNAs, we analyzed 51 samples (25 IGD 26 controls) using TaqMan Low Density Array. For validation, performed qRT-PCR 36 independent (20 16 controls). Results:...
BackgroundMyofibroblasts are known to play a key role in the development of idiopathic pulmonary fibrosis (IPF). Two drugs, pirfenidone and nintedanib, only approved therapeutic options for IPF, but their applications limited due side effects. Thus, curative IPF drugs represent huge unmet medical need.MethodsA mouse hepatic stellate cell (HSC) line was established that could robustly differentiate into myofibroblasts upon treatment with TGF-β. Eupatilin assessed diseased human lung...
A sensitive electrochemical sensor decorated with poly(<sc>l</sc>-methionine), carbon nanotube–graphene complexes and Au nanoparticles on a screen printed electrode for dopamine uric acid determination in human urine solution.
Abstract Glioblastoma, also known as glioblastoma multiforme (GBM), is the most malignant type of brain cancer and has poor prognosis with a median survival less than one year. While structural changes tumor cell surface carbohydrates are to be associated invasive behavior cells, glycoproteins differentiate low‐ high‐grade glioma cells can potential diagnostic markers therapeutic targets for GBMs. In present study, lectin arrays consisting eight lectins were employed explore carbohydrate...
Abstract Protein arginine methyltransferase 5 (PRMT5) is a major enzyme responsible for generating monomethyl and symmetric dimethyl in proteins. PRMT5 essential cell viability development, its overexpression observed variety of cancers. In the present study, it found that levels protein dimethylation colorectal cancer (CRC) tissues are increased compared to those adjacent noncancerous tissues. Using immunoaffinity enrichment methylated peptides combined with high‐resolution mass...
Startup of an anaerobic membrane reactor (AnMBR) involves a significant concentration active and functioning microbial communities participating in the process. Here, we monitored physical, microbial, functional performance during first 90 days AnMBR operation. The results indicate initiation digestion on 31–60 (transitional stage) its stabilization 61–90 (stable stage), with average COD removal efficiency 93.14 ± 1.41% biogas production 0.82 0.15 L/d. Moreover, population associated...
Vulnerability to internet gaming disorder (IGD) has increased as continues grow. Cocaine- and amphetamine-regulated transcript (CART) is a hormone that plays role in reward, anxiety, stress. The purpose of this study was identify the CART pathophysiology IGD.
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Recent studies have examined the structure-function relationship of high-density lipoprotein (HDL). This study aimed to identify and rank HDL-associated proteins involved in several biological function HDL.HDLs isolated from 48 participants were analyzed. Cholesterol efflux capacity, effect HDL on nitric oxide production, vascular cell adhesion molecule-1 expression assessed. The relative abundance identified highest vs. lowest quartile was expressed using normalized spectral factor...