A5088988475- Stress Responses and Cortisol
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Endometriosis Research and Treatment
- Menopause: Health Impacts and Treatments
- High Altitude and Hypoxia
- Fatty Acid Research and Health
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Plant chemical constituents analysis
- Plant Genetic and Mutation Studies
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Economic Growth and Development
- Plant and Fungal Species Descriptions
- Melanoma and MAPK Pathways
- Advanced MRI Techniques and Applications
- Estrogen and related hormone effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pituitary Gland Disorders and Treatments
- Genetic diversity and population structure
- Neurosurgical Procedures and Complications
- Phytochemical Studies and Bioactivities
- Nigella sativa pharmacological applications
Universidad Peruana Cayetano Heredia
2002-2023
United States Department of Agriculture
2013
Universidade Estadual Paulista (Unesp)
2008
Novo Nordisk (United States)
2007
Summary. Evidence suggests greater doses of recombinant activated factor VII (rFVIIa; NovoSeven ® , Novo Nordisk A/S, Bagsværd, Denmark) than currently administered may result in enhanced haemostasis and convenience for patients with haemophilia A B inhibitors. This study evaluated efficacy safety rFVIIa an prothrombin complex concentrate (APCC; Factor Eight Inhibitor Bypassing Activity [FEIBA] Baxter AG, Vienna, Austria) controlling joint bleeds a home‐treatment setting. Patients received...
INTRODUCTION: Chronic subdural hematoma (CSDH) represents a significant neurosurgical challenge, particularly prevalent among the elderly. It is commonly managed through surgical evacuation, yet recurrence rates remain at approximately 13%. Given these statistics, various adjuvant therapies have been explored, such as tranexamic acid (TXA) in order to improve outcomes. Despite efforts, there still no clear consensus regarding efficacy and safety of TXA this setting. This study aims assess...
INTRODUCTION: Open Surgery (OS) has become the standard of care for Drug Resistant Epilepsy (DRE). Similiarly, Laser Interstitial Thermal Therapy (LITT) emerged as a minimally invasive alternative. However, current comparative evidence is limited to observational cohorts, meta-analysis needed address this knowledge gap. METHODS: A literature search was conducted until March 14, 2024, identify studies comparing LITT and OS in patients with DRE. The primary outcomes were seizure freedom (SF),...
Abstract We studied the phylogeny of 22 accessions Daucus and seven in related genera, with DNA sequences from eight nuclear orthologs one plastid (psbA/trnH) region. Maximum parsimony maximum likelihood analyses concatenated data matrix 7,212 aligned nucleotides provided excellent bootstrap support for many clades. Concordant prior molecular results Pseudorlaya pumila was firmly imbedded within Daucus, as Margottia gummifera, a new finding. All D. capillifolius, carota, sahariensis formed...
Sacha Inchi (Plukenetia huayllabambana), an oleoleguminosae with a high content ω-3, could help normalize alterations of obesity. We evaluated the effect emulsion (SI) oil on lipid profile, oxidative stress and inflammation in serum liver tissue obesity-induced rats. Five groups induced to obesity by high-fat diet were analyzed. One group without treatment, two SI (OSI1:0.25 ω-3/day, OSI2:0.5 ω-3/day), one atorvastatin plus oil. The treated lowered values total cholesterol, triglycerides,...
Summary The aim of this study was to assess and apply a microsatellite multiplex system for parentage determination in alpacas. An approach testing based on 10 microsatellites evaluated population 329 unrelated alpacas from different geographical zones Perú. All markers, which amplified two reactions, were highly polymorphic with mean 14.5 alleles per locus (six 28 locus) an average expected heterozygosity ( H E ) 0.8185 (range 0.698–0.946). total exclusion probability 0.999456 excluding...
Abstract Objective This study aimed to evaluate the short-term efficacy and safety of an oral herbal supplement containing glucosinolates, phytosterols, citrus flavonoids for menopausal symptoms in comparison with estrogen plus progestogen therapy (EPT) among postmenopausal women. Methods was a pilot single-blinded, three-armed phase II randomized clinical trial, controlled EPT. Sixty participants were randomly assigned receive treatment 3 months: (1) 1,500 mg/d (G1, n = 20), (2) 3,000 (G2,...
Objective To evaluate the effect of a herbal preparation containing glucosinolates, phytosterols and citrus flavonoids (supplement) on body weight metabolic parameters usually impaired by menopause.Methods A pre-clinical experimental study carried out in twenty-five Swiss strain mice (Mus musculus) randomly distributed (1:1:1:1:1 ratio) to five groups receive for ten weeks: (1) oral gelatinized maca extract 0.5625 mg/kg/day + bilateral ovariectomy (Maca OVX); (2) supplement (S1 (3) 1.6875...
Objective To evaluate the safety and tolerability of an oral herbal supplement containing glucosinolates, phytosterols, citrus flavonoids (Warmi®, Lima Perú;) in otherwise healthy adult women.Methods This was a phase-I, randomized parallel three arms, double-blinded, placebo-controlled clinical trial. A total 55 participants aged 18-40 were randomly assigned to one groups receive for months: (1) 1650 mg/day; (2) 3300 or (3) placebo mg/day. The primary endpoints supplement. secondary endpoint...
People living at high‐altitude have lower fasting glucose levels and apparently incidence of type 2 diabetes. In lean mice, 4 weeks hypoxia also decreases increases insulin sensitivity in skeletal muscle. However, the effect chronic on metabolism obese intolerant rodents is unknown. We hypothesized that level improves tolerance rats. order to test this hypothesis, Sprague‐Dawley rats were fed with normal chow diet or high‐fat (45% Kcal from fat) for 24 a normoxic environment. Rats then...
Background: Obesity is characterized by excessive accumulation of adipose tissue and associated with higher risk metabolic diseases other comorbidities. Efficacious strategies including a diet high in “functional foods” are promising. Plukenetia huayllabambana known as Sacha Inchi (SI), legume which seeds rich proteins, tocopherols, fatty acids such omega-3 (ω-3). The latter has emerged potential protective nutrient against the cardiometabolic risks obesity. Omega-3 changes membrane lipid...
Chronic hypoxia decreases fasting glucose and increases utilization in lean obese rats. Hypoxia insulin sensitivity rats, but resistance remains higher compared to rats exposed (figure). Skeletal muscle plays an important role metabolism; thus changes pathway mitochondrial metabolism may impact skeletal uptake. We evaluated the adaptation of chronic hypothesized that have less protein content decreased activation ERK/MAPK pathway, one components insulin‐signaling cascade. For this purpose,...