A5052959924- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Renin-Angiotensin System Studies
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Wnt/β-catenin signaling in development and cancer
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Microfluidic and Capillary Electrophoresis Applications
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Child and Adolescent Psychosocial and Emotional Development
- Cannabis and Cannabinoid Research
- Wikis in Education and Collaboration
- Pharmacological Receptor Mechanisms and Effects
- Doctoral Education Challenges and Solutions
- Functional Brain Connectivity Studies
- Lipid Membrane Structure and Behavior
- Advances in Oncology and Radiotherapy
- Social Media in Health Education
George Washington University
2019-2024
Brown University
2013-2018
John Brown University
2017
University of Alabama at Birmingham
2007-2011
This article traces the history of peer review scientific publications, plotting development process from its inception to present-day application. We discuss merits and weaknesses, both perceived real, as well practicalities several major proposed changes system. It is our hope that readers will gain a better appreciation complexities and, when serving reviewers themselves, do so in manner enhance utility exercise. also propose an international on-line training program for accreditation...
Serotonin is a neurotransmitter with broad functions in brain development, neuronal activity, and behaviors; serotonin the prominent drug target several major neuropsychiatric diseases. The multiple actions of are mediated by diverse receptor subtypes associated signaling pathways. However, key components that mediate specific function neurotransmission have not been fully identified. This review will provide evidence from biochemical, pharmacological, animal behavioral studies showing...
Abstract Ventral tegmental area ( VTA ) dopaminergic neurons are key components of the reward pathway, and their activity is powerfully controlled by a diverse array inhibitory GABA ergic inputs. Two major sources nerve terminals within local interneurons in rostromedial nucleus RMT g). Here, using optogenetics, we compared synaptic properties synapses on dopamine selective activation afferents that originate from these two cell populations. We found little evidence co‐release glutamate...
Ventral tegmental area (VTA) glutamate neurons signal and participate in reward aversion-based behaviors. However, the neurochemical mechanisms that underlie how these contribute to motivated behaviors is unknown. We used a combination of optical sensors identify distinct inputs VTA behavior within female male transgenic mice. Activity increased for both reward-predicting aversion-predicting cues aversive outcomes, but subpopulations were or decreased by reward. For activity GABA mostly...
Understanding of the relationship between cellular function and molecular composition holds a key to next-generation therapeutics but requires measurement all types molecules in cells. Developments sequencing enabled semiroutine single-cell genomes transcriptomes, analytical tools are scarce for detecting diverse proteins tissue-embedded To bridge this gap neuroscience research, we report integration patch-clamp electrophysiology with subcellular shot-gun proteomics by high-resolution mass...
Stressful experiences potently activate kappa opioid receptors (κORs). κORs in the ventral tegmental area regulate multiple aspects of dopaminergic and non-dopaminergic cell function. Here we show that at GABAergic synapses on rat VTA dopamine neurons, a single exposure to brief cold-water swim stress induces prolonged activation κORs. This is mediated by receptor during stressor followed persistent, ligand-independent constitutive κOR itself. lasting change function not seen neighboring...
Serotonergic neurons in the dorsal raphe nucleus (DRN) play important roles early postnatal development maturation and modulation of higher-order emotional, sensory, cognitive circuitry. The pivotal functions these cells brain make them a critical substrate by which experience can be wired into brain. In this study, we investigated synapses onto serotonergic typically developing male female mice using whole cell patch-clamp recordings ex vivo slices. We show that while inhibition is...
Ventral tegmental area (VTA) dopamine neurons are of great interest for their central roles in motivation, learning, and psychiatric disorders. While hypotheses VTA neuron function posit a homogenous role behavior (e.g., prediction error), they do not account molecular heterogeneity. We find that glutamate-dopamine, nonglutamate-dopamine, glutamate-only dissociable signaling reward aversion-related stimuli, error, electrical properties. In addition, glutamate-dopamine nonglutamate-dopamine...
Dysregulation of the mesolimbic reward circuitry is implicated in pathophysiology stress-related illnesses such as depression and anxiety. These disorders are more frequently diagnosed females, sex differences response to stress likely be one factor that leads enhanced vulnerability females. In this study, we use subchronic variable (SCVS), a model which females uniquely vulnerable behavioral disturbances, investigate sexually divergent mechanisms regulation ventral tegmental area by stress....
Serotonergic neurons in the dorsal raphe nucleus (DRN) play important roles early postnatal development maturation and modulation of higher order emotional, sensory, cognitive circuitry. This unique position makes these cells a substrate by which experience can be wired into brain. In this study, we have investigated synapses onto serotonergic typically developing male female mice using whole-cell patch-clamp recordings
For junior investigators starting their independent careers, the challenges of Coronavirus Disease 2019 (COVID-19) pandemic extend beyond lost time and are career threatening. Without intervention, academic science could lose a generation talent.
ABSTRACT A two-neuron model of ventral tegmental area (VTA) opioid function classically involves VTA GABA neuron regulation dopamine neurons via a mu-opioid receptor dependent inhibitory circuit. However, this predates the discovery third major type in VTA: glutamatergic neurons. We find that about one-quarter expressing are glutamate without molecular markers co-release. Glutamate-Mu topographically distributed anterior VTA. The majority remaining GABAergic largely within posterior and do...
Ventral tegmental area (VTA) glutamate neurons signal and participate in reward aversion-based behaviors. However, the neurochemical mechanisms that underlie how these diverse motivated behaviors is unknown. We used a combination of optical sensors to identify distinct inputs VTA behavior. Glutamate increased for both reward- aversion-predicting cues aversive outcomes, but subpopulations were or decreased by reward. For all GABA GCaMP-measured neuronal activity increased. GCaMP recordings...