A5042485417- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Pesticide and Herbicide Environmental Studies
- Pesticide Residue Analysis and Safety
- Cancer Cells and Metastasis
- Analytical Chemistry and Chromatography
- Fibroblast Growth Factor Research
- Plant Pathogens and Fungal Diseases
- Weed Control and Herbicide Applications
- Glycosylation and Glycoproteins Research
- Fungal Plant Pathogen Control
- Trace Elements in Health
- Blood Coagulation and Thrombosis Mechanisms
- Plant Physiology and Cultivation Studies
- Cellular Mechanics and Interactions
- Connective tissue disorders research
- MicroRNA in disease regulation
- Analytical chemistry methods development
- Echinoderm biology and ecology
- Anatomy and Medical Technology
- Composting and Vermicomposting Techniques
- Nanoplatforms for cancer theranostics
- Pesticide Exposure and Toxicity
- RNA Interference and Gene Delivery
- Cassava research and cyanide
National University of Singapore
2011-2023
University Hospital Münster
2012
University College London
2002
United States Food and Drug Administration
1969-1985
Food and Drug Administration
1968
The heparan sulfate proteoglycan syndecan-1 (Sdc1) modulates cell proliferation, adhesion, migration and angiogenesis. Proteinase-mediated shedding converts Sdc1 from a membrane-bound coreceptor into soluble effector capable of binding the same ligands. In breast carcinomas, overexpression correlates with poor prognosis an aggressive phenotype. To distinguish between roles shed forms in cancer progression, human MCF-7 cells were stably transfected plasmids overexpressing wild-type (WT),...
Abstract microRNAs are small endogenous noncoding RNAs, which post‐transcriptionally regulate gene expression. In breast cancer, overexpression of the transmembrane heparan sulfate proteoglycan syndecan‐1, a predicted target oncomiR miR‐10b, correlates with poor clinical outcome. To investigate potential functional relationship miR‐10b and MDA‐MB‐231 MCF‐7 cancer cells were transiently transfected pre‐miR‐10b, syndecan‐1 siRNA or control reagents, respectively. Altered cell behavior was...
We studied 50 papillary lesions (25 papillomas and 25 ductal carcinomas in situ, DCIS) diagnosed at Singapore General Hospital, for immunohistochemical expression of cytokeratin (CK) 5/6, CK14, 34βE12. The immunoscore (proportion stained cells multiplied by staining intensity) was compared between the two groups. Cytokeratin corroborated confocal microscopy. Results were applied to a separate series 43 tumors from Hong Kong (HK). CK5/CK6, 34βE12 showed higher immunoscores (mean values,...
Tenascin-C, an extracellular matrix molecule of the tumor-specific microenvironment, counteracts tumor cell proliferation-suppressing effect fibronectin by blocking integrin alpha(5)beta(1)/syndecan-4 complex. This causes rounding and stimulates proliferation. Tenascin-C also endothelin receptor type A (EDNRA) expression. Here, we investigated whether signaling through receptors affects tenascin-C-induced rounding. We observed that B (EDNRB) activation inhibited tenascin-C induced spreading...
Abstract Glycosaminoglycans (GAGs) regulate many important physiological processes. A pertinent issue to address is whether GAGs encode functional information via introduction of position specific sulfate groups in the GAG structure. However, procurement pure, homogenous motifs probe “sulfation code” a challenging task due isolation difficulty and structural complexity. To this end, we devised versatile synthetic strategy obtain all 16 theoretically possible sulfation patterns chondroitin...
Abstract Background Coronavirus Disease 2019 (COVID-19) has become a major global issue with rising the number of infected individuals and mortality in recent months. Among all therapeutic approaches, arguments have raised about hydroxychloroquine (HCQ) efficacy treatment COVID-19. We carried out systematic review meta-analysis overcome controversies regarding effectiveness Methods A search was performed PubMed, Scopus, Embase, Cochrane Library, Web Science, Google Scholar medRxiv pre-print...
Reduced activity of ß4-galactosyltransferase 7 (ß4GalT-7), an enzyme involved in synthesizing the glycosaminoglycan linkage region proteoglycans, is associated with progeroid form Ehlers–Danlos syndrome (EDS). In invertebrates Drosophila melanogaster and Caenorhabditis elegans, mutations ß4GalT-7 affect biosynthesis heparan sulfate (HS), a modulator several biological processes relevant to wound repair. We have analyzed structural alterations HS their functional consequences human Arg270Cys...
In colon cancer, downregulation of the transmembrane heparan sulfate proteoglycan syndecan-1 (Sdc-1) is associated with increased invasiveness, metastasis, and dedifferentiation. As Sdc-1 modulates signaling pathways relevant to stem cell function, we tested hypothesis that it may regulate a tumor-initiating phenotype. small-interfering RNA knockdown in human cancer lines Caco2 HT-29 resulted an side population (SP), enhanced aldehyde dehydrogenase 1 activity, higher expression CD133, LGR5,...
Journal Article The Chemistry and Mode of Action Herbicides Get access Herbicides,Edited By Crafts A S, Interscience Publishers, New York, , 1961. 269 pp. Index, bibliography. George Yip Search for other works by this author on: Oxford Academic Google Scholar Association Official Agricultural Chemists, Volume 44, Issue 4, 1 November 1961, Page 801, https://doi.org/10.1093/jaoac/44.4.801 Published: 01 February 2020
Abstract Purpose While the stem cell marker Musashi-1 (MSI-1) has been identified as a key player in wide array of malignancies, few findings exist on its prognostic relevance and for cancer death therapy resistance breast cancer. Methods First, we determined MSI-1 database analyses regarding multiple survival outcomes. To substantiate findings, was artificially downregulated MCF-7 cells implications markers, apoptosis regulator p21, proliferation radiation response were analyzed via flow...
Present day strategies for delivery of wireless photodynamic therapy (PDT) to deep-seated targets are limited by the inadequacy irradiance and insufficient therapeutic depth. Here we report design preclinical validation a flexible upconversion nanoparticle (UCNP) implant (SIRIUS) that is capable large field, high intensity illumination PDT tumors. The achieves this incorporating submicrometer core–shell–shell NaYF4 UCNPs into its design, which significantly enhances efficiency mitigates...
Journal Article Malathionase. I. Activity and Inhibition Get access J W Cook, Cook Food Drug Administration, Department of Health, Education, Welfare, Washington 25, D.C Search for other works by this author on: Oxford Academic Google Scholar Jane R Blake, Blake George Yip, Yip Martin Williams Association Official Agricultural Chemists, Volume 41, Issue 2, 1 May 1958, Pages 399–407, https://doi.org/10.1093/jaoac/41.2.399 Published: 07 February 2020
Breast carcinoma is the most prevalent cancer in women globally, with complex genetic and molecular mechanisms that underlie its development progression. Several challenges such as metastasis drug resistance limit prognosis of breast cancer, hence a constant search for better treatment regimes, including novel therapeutic targets necessary. Complement component 1, q subcomponent binding protein (C1QBP), promising target, has been implicated carcinogenesis. In this study, role C1QBP...