A5091358299- Electromagnetic Fields and Biological Effects
- Genetics and Neurodevelopmental Disorders
- Muscle Physiology and Disorders
- Photodynamic Therapy Research Studies
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatment
- Luminescence Properties of Advanced Materials
- Spaceflight effects on biology
- Neurogenetic and Muscular Disorders Research
National University of Singapore
2020-2025
National University Health System
2024-2025
Briefly (10 min) exposing C2C12 myotubes to low amplitude (1.5 mT) pulsed electromagnetic fields (PEMFs) generated a conditioned media (pCM) that was capable of mitigating breast cancer cell growth, migration, and invasiveness in vitro, whereas the harvested from unexposed myotubes, representing constitutively released secretome (cCM), less effective. Administering pCM microtumors engrafted onto chorioallantoic membrane chicken eggs reduced tumor volume vascularity. Blood serum collected...
Present day strategies for delivery of wireless photodynamic therapy (PDT) to deep-seated targets are limited by the inadequacy irradiance and insufficient therapeutic depth. Here we report design preclinical validation a flexible upconversion nanoparticle (UCNP) implant (SIRIUS) that is capable large field, high intensity illumination PDT tumors. The achieves this incorporating submicrometer core–shell–shell NaYF4 UCNPs into its design, which significantly enhances efficiency mitigates...
Preclinical studies have shown that the blood from female mice exposed weekly to magnetic fields inhibited breast cancer growth. This double-blind randomized controlled trial investigated whether analogous therapy could produce similar anticancer sera human subjects. Twenty-six healthy adult females (ages 30-45) were assigned either a group, receiving twice 1 mT exposures (10 min/session) for 4 weeks, or control who underwent identical sham exposure. Blood evaluated their capacity modulate...
FEZ1-mediated axonal transport plays important roles in central nervous system development but its involvement the peripheral is not well-characterized. FEZ1 deleted Jacobsen syndrome (JS), an 11q terminal deletion developmental disorder. JS patients display impaired psychomotor skills, including gross and fine motor delay, suggesting that may be responsible for these phenotypes, given association with of motor-related circuits. Supporting this hypothesis, our data show selectively expressed...