A5004360001- Synthesis and biological activity
- Synthesis of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Protein Kinase Regulation and GTPase Signaling
- Quinazolinone synthesis and applications
- Synthesis and Reactivity of Heterocycles
- Cancer therapeutics and mechanisms
- Phytochemical compounds biological activities
- Tuberculosis Research and Epidemiology
- Biochemical and Molecular Research
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- 14-3-3 protein interactions
- Medicinal plant effects and applications
- RNA and protein synthesis mechanisms
- Fibroblast Growth Factor Research
Institute of Molecular Biology and Genetics
2017-2022
National Academy of Sciences of Ukraine
2022
Background: Serine/threonine protein kinase CK2 is involved in the regulation of a number cellular functions such as cell growth, proliferation, differentiation and apoptosis. Increased activity associated with development different types cancer, inflammatory response, pain virus infections. Therefore, an attractive molecular target for small-molecular inhibitors which can be important compounds pharmaceutical application. Objective: The main aim this research to identify novel chemical...
Keywords: synthesis, indazole, quinazoline, thieno[2,3-d]pyrimidine, pyrazolo[3,4-d]pyrimidine, protein kinase CK2 inhibitor
Background: Overactivity of fibroblast growth factor receptor 1 (FGFR1) is associated with various tumors, particularly breast cancer, prostate non-small-cell lung carcinoma, myeloproliferative diseases, which makes this protein kinase a promising therapeutic target for anticancer therapy. Objective: The main aim study to identify novel FGFR1 inhibitors. Method: In order find inhibitors, virtual screening experiments were performed using AutoDock software. Best-scored compounds tested in...
Aurone derivatives possessing a wide range of biological activities are high interest in medicinal chemistry. Carboxylated aurones were found previously to inhibit xanthine oxidase, which is potential target for treatment hyperuricemia and gout. In this paper, series B-ring nitro-substituted aurone studied vitro as inhibitors enzyme. The introduction hydroxyl group into the nitro-functionalized resulted significant increase their inhibitory potency. At same time, chlorinated at ring A...
The cytotoxic effect of several synthetic nitrogen-containing heterocyclic compounds on cultures tumour and normal cells the calculation their ADME, QSAR, DFT pharmacological properties
 aim. purpose our work was to investigate influence some compounds, namely imidazole, aurones, triazole culture melanoma mouse B16, human glioma U251 HEK293 properties calculation.
 Materials methods. estimation cell viability in conditions investigated drugs carried out by MTT. ADME data screening...
Keywords: protein kinase CK2 inhibitor, in vitro assay, molecular docking, indazole, pyrazolo[3,4-d]pyrimidine
Keywords: Indazole, chemical synthesis, luciferase luminescent kinase assay, protein inhibitor, CK2