A5001695399- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Neural dynamics and brain function
- Retinal Development and Disorders
- Child and Animal Learning Development
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Retinal Imaging and Analysis
- Spatial Cognition and Navigation
- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Neurological Disease Mechanisms and Treatments
- Ethnobotanical and Medicinal Plants Studies
- Acute Ischemic Stroke Management
- Phytochemicals and Medicinal Plants
- Cancer-related cognitive impairment studies
- Infant Development and Preterm Care
- Advanced Glycation End Products research
- Retinal and Optic Conditions
University of Iowa
2022-2024
The University of Texas at San Antonio
2015-2022
University of Pennsylvania
2009-2015
The University of Texas Health Science Center at San Antonio
2015
Howard Hughes Medical Institute
1999-2010
Columbia University
2001-2010
California University of Pennsylvania
2009
Rutgers, The State University of New Jersey
1995-2000
New York State Psychiatric Institute
1999
MAP kinase (ERK) translates cell surface signals into alterations in transcription. We have found that ERK also regulates hippocampal neuronal excitability during 5 Hz stimulation and thereby forms of long-term potentiation (LTP) do not require macromolecular synthesis. Moreover, ERK-mediated changes are selectively required for some LTP but others. is the early phase elicited by brief stimulation, as well more prolonged when paired with beta1-adrenergic receptor activation. By contrast,...
A key question in the analysis of hippocampal memory relates to how attention modulates encoding and long-term retrieval spatial nonspatial representations this region. To address question, we recorded from single cells over a period 5 days CA1 region dorsal hippocampus while mice acquired one two goal-oriented tasks. These tasks required animals find hidden food reward by attending either visuospatial environment or particular odor presented shifting locations. Attention increased stability...
Compared with the dorsal hippocampus, relatively few studies have characterized neuronal responses in ventral hippocampus. In particular, it is unclear whether and how cells region represent space and/or respond to contextual changes. We recorded from CA1 neurons freely moving mice exposed manipulations of visuospatial olfactory contexts. found that alterations environment such as exposure novel local cues, cue rotations, expansion similar ways cells, exception rotations. Furthermore, we...
Abstract Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation microglia, the resident phagocytes retina, promoting neuronal and vascular damage. The microglial receptor, CX3CR1, binds fractalkine (FKN), an anti-inflammatory chemokine that is expressed on membranes (mFKN), undergoes constitutive cleavage release a soluble domain (sFKN). Deficiencies in CX3CR1 or FKN showed increased activation,...
Diabetic retinopathy (DR)-associated vision loss is a devastating disease affecting the working-age population. Retinal pathology due to leakage of serum components into retinal tissues, activation resident phagocytes (microglia), and vascular neuronal damage. While short-term interventions are available, they do not revert visual function or halt progression. The impact microglial inflammatory responses on neurovascular unit remains unknown. In this study, we characterized...
Fear is an emotional response to danger that highly conserved throughout evolution because it critical for survival. Accordingly, episodic memory fearful locations widely studied using contextual fear conditioning, a hippocampus-dependent task (Kim and Fanselow, 1992; Phillips LeDoux, 1992). The hippocampus has been implicated in thought integrate stimuli within spatial framework. Physiological evidence supporting the role of indicates pyramidal cells this region, which fire specific as...
The study of fear memory is important for understanding various anxiety disorders in which patients experience persistent recollections traumatic events. These memories often involve associations contextual cues with aversive events; consequently, Pavlovian classical conditioning commonly used to learning. use predator odor as a fearful stimulus has become increasingly an animal model disorders. Innate responses odors are well characterized and reliable; however, attempts these unconditioned...
The extinction of learned fear is a hippocampus-dependent process thought to embody new learning rather than erasure the original memory, although it unknown how these competing contextual memories are represented in hippocampus. We previously demonstrated that conditioning results hippocampal place cell remapping and long-term stabilization novel representations. Here we report also induces C57BL/6 mice. Specifically, observed cells preferentially remapped during different stages learning....
Significance The ability to recover one’s bearings when lost is critical for successful navigation. To accomplish this feat, a navigator must identify its current location (place recognition), and it also facing direction (heading retrieval). Using novel behavioral paradigm, we demonstrate that mice use one set of cues determine their then ignore these same determining heading, although the are informative in both cases. These results suggest place recognition heading retrieval mediated by...
Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations possible unknown. In this study, we report how deprivation (SD) affects hippocampal representations, patterns, memory in young old mice. After training a hippocampus-dependent object-place recognition (OPR) task, control animals ad libitum, although experimental undergo 5 h SD, followed by recovery sleep. Young controls SD mice exhibit successful OPR memory, whereas are impaired....
Microglia-mediated inflammation plays a significant role in neuronal and vascular damage diabetic retinopathy (DR), but the mechanism linking inflammation, neurodegeneration, impaired integrity is still unclear. Previous studies from mouse models showed accumulation of fibrinogen at vessel lesions surrounded by perivascular microglial clusters. The purpose this study was to evaluate whether pathological hallmarks gliosis aberrations characterized animal are consistent with those human...
Type B photoreceptors in Hermissendaexhibit increased excitability (e.g., elevated membrane resistance and lowered spike thresholds) consequent to the temporal coincidence of a light-induced intracellular Ca 2+ increase release GABA from presynaptic vestibular hair cells. Convergence these pre- postsynaptically stimulated biochemical cascades culminates activation protein kinase C (PKC). Paradoxically, exposure cell light alone generates an inositol triphosphate-regulated rise diacylglycerol...
Following contiguous pairings of light and rotation, alone elicits a conditioned contraction Hermissenda's foot, indicative an associative memory. After 5-min retention interval, this response was evident following two or nine (but not one) conditioning trials but persisted for 90 min only after trials. In vivo incubation animals in the protein synthesis inhibitor anisomycin (ANI; 1 microM) did affect at interval significantly attenuated responding 90-min even training Deacetylanisomycin...
An incremental increase in the excitability (i.e., input resistance, evoked spike frequency) of B photoreceptors Hermissenda accompanied successive pairings light and presynaptic stimulation vestibular hair cells (simulating light-rotation an intact animal). Analysis protein kinase C (PKC) Hermissenda's indicated a training-induced reduction PKC cytosolic compartments, tendency toward membrane small decrease total enzyme activity (possibly owing to downregulation or conversion...
Although predator odors are ethologically relevant stimuli for rodents, the molecular pathways and contribution of some brain regions involved in odor conditioning remain elusive. Inhibition histone deacetylases (HDACs) dorsal hippocampus has been shown to enhance shock-induced contextual fear learning, but it is unknown if HDACs have differential effects along dorso-ventral hippocampal axis during learning. We injected MS-275, a class I HDAC inhibitor, bilaterally or ventral mice found that...
Reorientation enables navigators to regain their bearings after becoming lost. Disoriented individuals primarily reorient themselves using the geometry of a layout, even when other informative cues, such as landmarks, are present. Yet specific strategies that animals use determine unclear. Moreover, because vision allows subjects rapidly form precise representations objects and background, it is unknown whether has deterministic role in geometry. In this study, we tested sighted congenitally...