A5055333667- Trypanosoma species research and implications
- Viral Infections and Immunology Research
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Estrogen and related hormone effects
- Synthesis and Characterization of Heterocyclic Compounds
- RNA and protein synthesis mechanisms
- Research on Leishmaniasis Studies
- Plant chemical constituents analysis
- Protein Degradation and Inhibitors
- Multicomponent Synthesis of Heterocycles
- Evacuation and Crowd Dynamics
- MicroRNA in disease regulation
- Micro and Nano Robotics
- Tannin, Tannase and Anticancer Activities
- Zebrafish Biomedical Research Applications
- HER2/EGFR in Cancer Research
- Bone Metabolism and Diseases
- Multilevel Inverters and Converters
- Advanced Electron Microscopy Techniques and Applications
- Advanced Thermodynamics and Statistical Mechanics
- Bioactive Compounds and Antitumor Agents
- Traffic and Road Safety
- Genomics, phytochemicals, and oxidative stress
Meharry Medical College
2020-2023
Central Drug Research Institute
2015-2019
University of Lucknow
2015-2016
University of Michigan
2011
The potential of coumarin–imidazo[1,2-<italic>a</italic>]pyridine hybrids to prevent bone loss in patients with metastases is discussed.
How do worms navigate their complex natural surroundings? Undulatory microswimmers such as nematodes typically inhabit environments soil, vegetable matter, and host tissues. While the habitats of are often three-dimensional granular niches with spatiotemporally varying visco-elasto-plastic material properties that impose physical constraints on motion, current knowledge about nematode motility patterns broadly comes from investigating model organisms Caenorhabditis elegans either inside...
A novel class of gallic acid based glycoconjugates were designed and synthesized as potential anticancer agents. Among all the compounds screened, compound 2a showed potent activity against breast cancer cells. The latter resulted in tubulin polymerization inhibition induced G2/M cell cycle arrest, generation reactive oxygen species, mitochondrial depolarization subsequent apoptosis In addition, ultraviolet-visible spectroscopy fluorescence quenching studies with confirmed direct interaction...
Trypanosoma cruzi , the etiological agent of Chagas Disease, causes severe morbidity, mortality, and economic burden worldwide. Though originally endemic to Central South America, globalization has led increased parasite presence in most industrialized countries. About 40% infected individuals will develop cardiovascular, neurological, and/or gastrointestinal pathologies. Accumulating evidence suggests that induces alterations host gene expression profiles order facilitate infection...
Abstract Objectives In our ongoing studies to develop ER targeting agents, we screened for dual‐acting molecules with a hypothesis that single molecule can also target both positive and negative groups of breast cancer. Materials methods 1‐(2‐(4‐(Dibenzo[b,f]thiepin‐10‐yl)phenoxy)ethyl)piperidine ( DTPEP ) was synthesized in MCF ‐7 +ve) MDA ‐ MB ‐231 ‐ve) cells. Assays analysis cell cycle, ROS, apoptosis MMP loss were carried out using flow cytometry. Its investigated western blot,...
The synthesis of estradiol based bivalent ligand [(EST)2DT] is reported and its potential for targeted imaging therapy ER(+) tumors has been evaluated. For the purpose, ethinylestradiol was functionalized with an azidoethylamine moiety via click chemistry. resultant derivative reacted in a mode DTPA-dianhydride to form multicoordinate chelating agent, (EST)2DT which displayed capability bind (99m)Tc. radiolabeled complex, (99m)Tc-(EST)2DT obtained >99% radiochemical purity 20-48 GBq/μmol...
A library of 3,4,6-triaryl-2-pyridones has been synthesized using multicomponent reaction (MCR) substituted acetophenones, benzaldehydes and phenyl acetamides. All the compounds were evaluated for their anti-breast cancer activity, in vitro ER+ ER- cell lines, wherein, 11 (4-(3,4-dimethoxyphenyl)-6-(4-methoxyphenyl)-3-phenylpyridin-2(1H)-one) 35 (3,6-bis(4-methoxyphenyl)-4-(4-(2-(piperidin-1-yl) ethoxy)phenyl)pyridin-2(1H)-one) found to be most active with best safety profile towards...
The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease. This neglected tropical disease causes severe morbidity and mortality in endemic regions. About 30% T. infected individuals will present with cardiac complications. Invasive trypomastigotes released from cells can be carried vascular endothelial system to infect neighboring distant cells. During process cellular infection, induces host cells, increase levels thrombospondin-1 (TSP-1), facilitate infection....
Trypanosoma cruzi dysregulates the gene expression profile of primary human cardiomyocytes (PHCM) during early phase infection through a mechanism which remains to be elucidated. The role that small non-coding RNAs (sncRNA) including PIWI-interacting RNA (piRNA) play in regulating is unknown. To understand how T. dysregulate heart, we challenged PHCM with trypomastigotes and analyzed sncRNA, especially piRNA, by RNA-sequencing. parasite induced significant differential host piRNAs, can...
The protozoan parasite, Trypanosoma cruzi, causes severe morbidity and mortality in afflicted individuals. Approximately 30% of T. cruzi infected individuals present with cardiac pathology. invasive forms the parasite are carried vascular system to infect other cells body. During transportation, molecular mechanisms by which signals interact host endothelial (EC) especially heart endothelium is currently unknown. increases thrombospondin-1 (TSP1) expression activates Wnt/β-catenin hippo...
, the etiological agent of Chagas disease, is an intracellular protozoan parasite, which now present in most industrialized countries. About 40%
Trypanosoma cruzi, the etiological agent of Chagas Disease, causes severe morbidity, mortality, and economic burden in endemic zones. Due to globalization, disease is now present all industrialized regions world. About 40% infected individuals will develop cardiovascular, neurological, and/or gastrointestinal pathologies. Cardiomyopathies induced by chronic parasite infection include organ enlargement fibrosis, accompanied significant changes cellular expression profibrotic factors...
Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, has infected 6 million people, putting 70 people at risk worldwide. Presently, very limited drugs are available, and these have severe side effects. Hence, there is an urgency to delve into other pathways targets for novel drugs. cruzi) expresses a number different cyclic AMP (cAMP)-specific phosphodiesterases (PDEs). cAMP one key regulators mammalian cell proliferation differentiation, it also plays important role in T....
Extended abstract of a paper presented at Microscopy and Microanalysis 2011 in Nashville, Tennessee, USA, August 7–August 11, 2011.
Trypanosoma cruzi, the causative agent of Chagas Disease, is an obligate intracellular parasite that has caused severe mortality and morbidity historically in Central South America. Due to international travel, globalization, migration, this neglected tropical disease now present most industrialized countries. About 30% those who develop chronic T. cruzi infection will exhibit various pathologies, including cardiomyopathies, neurological and/or gastrointestinal diseases. We others have...
Trypanosoma cruzi is an obligate intracellular hemoflagellate parasite which cause Chagas disease. This neglected tropical disease causes severe morbidity and mortality in endemic regions. 30% of chronically infected people suffer from cardiac disorder. heart diseasecan lead to sudden death due arrhythmias or progressive failure. Invasive trypomastigotes released cells can be carried vascular endothelial system infect neighboring distant cells. During the process cellular infection, induces...
Small noncoding RNAs (sncRNA) have been implicated as major contributors to the pathogenesis of various diseases. PIWI-Interacting RNA (piRNA) are a type sncRNA. with several regulatory roles across genome. They primarily expressed from piRNA clusters within genome, where they go on regulate and maintain genomic stability. capable silencing transposable elements inducing epigenetic changes. Some studies also suggest that piRNAs can gene transcription. This mechanism is thought be similar...