A5014518945- Viral Infectious Diseases and Gene Expression in Insects
- Microfluidic and Bio-sensing Technologies
- Pesticide Exposure and Toxicity
- Aerosol Filtration and Electrostatic Precipitation
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Lattice Boltzmann Simulation Studies
- Pesticide and Herbicide Environmental Studies
- Environmental Toxicology and Ecotoxicology
- Membrane Separation Technologies
Keck Graduate Institute
2018
Amgen (United States)
2018
Boehringer Ingelheim (United States)
2018
Whittier College
2012
Abstract Alternating tangential flow (ATF) filtration has been successfully adopted as a low shear cell separation device in many perfusion‐based processes. The reverse per cycle is used to minimize fouling compared with filtration. Currently, modeling of the ATF system based on empirically derived formulas, leading oversimplification model parameters. In this study, an experimentally validated porous computational fluid dynamic (CFD) was predict localized behavior and pressure profiles...
Tangential flow filtration (TFF) and alternating tangential (ATF) technologies using hollow fiber membranes are commonly utilized in perfusion cell culture for the production of monoclonal antibodies; however, product retention remains a known common problem with these systems. To address this issue, commercially available fibers ranging from several hundred kilo-Daltons (kDa) to 0.65 μm nominal pore size tested all demonstrated undergo moderate severe retention. Further investigation...
Organophosphate pesticides are known to inhibit acetylcholine esterase, an enzyme that degrades at the cholinergic synapse. In this study zebrafish were used understand impact chlorpyrifos, dichlorvos, and diazanon on vertebrate developmental physiology. Pre‐epiboly embryos exposed concentrations ranging from 1μM 1mM. Survival, spontaneous movements, heart rate, swimming behavior, physical abnormalities examined. All three found be toxic developing or above than 100 μM. However, disruption...