A5103884845- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Renal and Vascular Pathologies
- Cytomegalovirus and herpesvirus research
- Chronic Kidney Disease and Diabetes
- Pregnancy and Medication Impact
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Advanced Nanomaterials in Catalysis
- Ion Transport and Channel Regulation
- Polyomavirus and related diseases
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Neurological and metabolic disorders
- Muscle and Compartmental Disorders
- Genetic and Kidney Cyst Diseases
- Heat shock proteins research
- Cystic Fibrosis Research Advances
- GDF15 and Related Biomarkers
- Hepatitis B Virus Studies
- Abdominal vascular conditions and treatments
Koç University
2023-2025
Istanbul University
2016-2022
<b><i>Background:</i></b> C3 glomerulopathy (C3GP) is a recently identified and described disease that has high risk of progressing into end-stage renal disease. We aimed to evaluate the effects various immunosuppressive regimens on C3GP progression because there are conflicting data treatment modalities. <b><i>Methods:</i></b> In this retrospective study 66 patients with C3GP, 27 received mycophenolate mofetil (MMF)-based treatment, 23...
HLA‐B*39:199 differs from HLA‐B*39:10:01 by a G → A substitution in exon 5 codon 282.
BACKGROUND Cytomegalovirus (CMV) and BK virus (BKV) are post-transplant opportunistic viral infections that affect patient graft survival. This study was designed to evaluate the risk of BKV nephropathy CMV disease in kidney transplant recipients who received induction therapy with ATG or basiliximab. MATERIAL AND METHODS We retrospectively analyzed information on 257 adult patients underwent transplantation between January 2007 2017. Patients were categorized into 3 groups according...
Abstract Background This study aims to examine the association of LIM zinc finger domain containing 1 (LIMS1) genotype with allograft rejection in an independent kidney transplant cohort. Methods We genotyped 841 recipients for LIMS1 rs893403 variant by Sanger sequencing followed polymerase chain reaction confirmation deletion. Recipients who were homozygous GG compared AA/AG genotypes. The primary outcome was T cell–mediated or antibody-mediated (TCMR ABMR, respectively) and secondary loss....
Introduction Autoimmune hepatitis (AIH) is a chronic liver disease caused by perturbed immune system. The scarcity of short- and long-term monitoring AIH hampered us to comprehend the interaction between immunosuppressive medication homeostasis. Methods patients We recruited children with at time diagnosis 1st, 3rd, 6th, 12th, 18th, 24th months immunosuppression (IS). also enrolled being on IS for &gt;2 years. Children drug-induced injury (DILI), those receiving tacrolimus after...
Various molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, apoptosis. Heat shock proteins (HSPs) implicated the progression of chronic kidney disease (CKD). Our aim was to evaluate changes urine serum HSP levels over time their relationships with clinical parameters CKD children. In total, 117 children 56 healthy were examined. The group followed up prospectively for 24 months. Serum HSP27, HSP40, HSP47, HSP60,...
Abstract Introduction Genetic mutations such as C599T polymorphism in glutathione peroxidase [GPX1] gene and polymorphisms potassium channel (KCNJ11) genes have recently been proposed the etiopathogenesis of new onset diabetes mellitus after renal transplantation (NODAT). We aimed to examine association GPX1 KCNJ11 NODAT. Materials Methods This is a monocenter case-control study with total 118 transplant recipients who were divided into 2 groups; NODAT normal glucose tolerance. Relation...
Objective: Patients with chronic kidney disease (CKD) are susceptible to systemic inflammation and nutritional disorders, which associated morbidity mortality. The aim of the present study was evaluate relationship between status, lean body mass, physical activity, in patients stage 3-5 non-dialysis-dependent CKD. Methods: A total 55 predialysis CKD were included this cross-sectional study. divided into two groups according Subjective Global Assessment: 35 normal status (NN) 20 malnutrition...
Background: Laparoscopic partial nephrectomy, which minimizes renal function loss due to its nephron sparing nature, has become a standard technique among many experienced centers worldwide for surgical treatment of localized kidney tumors.Although nephrectomy will remain the gold standard, we need improve perioperative management and method prevent postoperative acute injury.Aims: To demonstrate frequency development injury following laparoscopic in patients with healthy contralateral...
Istanbul Medical Faculty, Department of Biology, as the first EFI-accredited HLA laboratory in Turkey since 1999 has been organizing both national and international quality control tests for typing under banner "Balkan external proficiency testing (BEPT)" encompassing countries from EFI regions 8. The round BEPT 2004 was organized low-resolution HLA-A,-B by molecular methods 12 centres participated exercise. In 2005, HLA-DR added, 2007, HLA-C DQ were added to exercise 28 participated. 2015,...
Significant effects of several modifying genes on the clinical features cystic fibrosis (CF) have been reported. In present study, researchers investigated transforming growth factor beta 1 (TGFB1) and cluster differentiation 14 (CD14) polymorphisms status patients with CF. The study included sixty-five CF eighty five healthy controls no pulmonary disease. Single-nucleotide in TGFB1 gene (rs1800469, rs1800470, rs8179181) were studied using DNA sequence analyses; CD14 polymorphism rs2569190...