A5101972238- 3D Printing in Biomedical Research
- CAR-T cell therapy research
- Parasites and Host Interactions
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- MicroRNA in disease regulation
- Coal Properties and Utilization
- Biomedical Ethics and Regulation
- Atmospheric and Environmental Gas Dynamics
- Cell Image Analysis Techniques
- Malaria Research and Control
- Innovative Microfluidic and Catalytic Techniques Innovation
- Trace Elements in Health
- Amoebic Infections and Treatments
- Biological Stains and Phytochemicals
- RNA Research and Splicing
- Pancreatitis Pathology and Treatment
- Developmental Biology and Gene Regulation
- Marine Bivalve and Aquaculture Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cytomegalovirus and herpesvirus research
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Biomedical and Engineering Education
Sichuan Agricultural University
2023-2024
Ministry of Education of the People's Republic of China
2024
Sichuan Center for Disease Control and Prevention
2024
Bioprocessing Technology Institute
2020-2022
Agency for Science, Technology and Research
2016-2022
Nanjing Maternity and Child Health Care Hospital
2021
Nanjing Medical University
2021
Singapore Immunology Network
2016
Peking University
2002-2014
The development of an effective malaria vaccine has remained elusive even until today. This is because our incomplete understanding the immune mechanisms that confer and/or correlate with protection. Human volunteers have been protected experimentally from a subsequent challenge by immunization Plasmodium falciparum sporozoites under drug cover. Here, we demonstrate sera individuals contain neutralizing antibodies against pre-erythrocytic stage. To identify antigen(s) recognized these...
Duck Tembusu virus (DTMUV), belonging to the Flaviviridae family, is a major that affects duck health in China. MicroRNAs (miRNAs) play an important role viral replication. However, little known about function of miRNAs during DTMUV infection. Here, host miR-146b-5p was found regulate When infected embryo fibroblasts (DEFs), expression levels increased significantly over time. Moreover, RNA copies, E protein and titers were all upregulated when overexpressed DEFs. The opposite results also...
The preplacodal region (PPR) is a of specialized ectoderm at the border neural and nonneural (NNE). Coordinated Bmp, Fgf, Wnt signals are known to drive PPR development; however, underlying mechanism unknown.We identified key components involved in differentiation. mesoderm/marginal Wnts early gastrula stage trigger differentiation by allowing adjacent NNE cells start adopting caudal fates; otherwise, development identity hindered due persistent presence gata3 mRNA. fate dominates when foxi1...
Following staining with hematoxylin and eosin Y, paraffin sections of mouse pancreas were examined by transmitted light, epifluorescence confocal laser scanning microscopy. Light microscopy revealed that the nuclei pancreatic acinar cells located basally, while apices appeared eosinophilic, although secretory granules difficult to visualize. Under violet-blue light excitation, zymogen at showed strong yellowish fluorescence; other part cytoplasm was only faintly fluorescent supporting...
DHAV-1 is a highly infectious pathogen that can cause acute hepatitis in ducklings. MicroRNA (miRNA) plays an essential regulatory role virus response. We characterized and compared miRNA mRNA expression profiles duck embryonic fibroblasts (DEF) the liver of ducklings infected with DHAV-1. DEF was divided into infection group (D group) blank (M group), duckling (H (N group). D vs. M have 130 differentially expressed (DE) (DEM) 2204 (DEG), H N 72 DEM 1976 DEG. By intersection comparisons, 15...
Abstract Vulvovaginal candidiasis (VVC) caused by Candida spp. affects 70–75% of women at least once during their lives. We aim to elucidate the potential mechanism VVC and investigate therapeutic effects long noncoding RNA 9708-1. Female BALB/c mice were randomized four treatment groups, including blank control group, vehicle group lncRNA 9708-1-overexpressed group. Mice euthanized on Day 4, 7 14 after treatment. Colony-forming unit (CFU) was measured, inflammation detected hematoxylin...
We show a machine learning-aided UV spectroscopy-based method using aseptic instrumentation to detect metabolite NA, marker of microbial contamination. This potentially enables rapid, at-line contamination detection in cell manufacturing.