A5075356726- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Blood Pressure and Hypertension Studies
- Neurological Disease Mechanisms and Treatments
- Nutrition and Health in Aging
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Stroke Rehabilitation and Recovery
- Optical Imaging and Spectroscopy Techniques
- Nutritional Studies and Diet
- Sports Performance and Training
- Adipose Tissue and Metabolism
- Health, Environment, Cognitive Aging
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Muscle activation and electromyography studies
- Osteoarthritis Treatment and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
The University of Texas Southwestern Medical Center
2018-2025
Texas Health Dallas
2018-2025
Southwestern Medical Center
2025
Presbyterian Hospital
2019-2024
Institute for Exercise and Environmental Medicine
2019-2024
The University of Texas at Austin
2014-2019
Tufts University
2013-2015
Objective. Arthritis and its associated joint pain act as significant barriers for adults attempting to perform land-based physical activity. Swimming can be an ideal form of exercise patients with arthritis. Yet there is no information on the efficacy regular swimming involving The effect a intervention pain, stiffness, function was evaluated in osteoarthritis (OA). Methods. Using randomized study design, 48 sedentary middle-aged older OA underwent 3 months either or cycling training....
Central arterial stiffness and brain hypoperfusion are emerging risk factors of Alzheimer's disease (AD). Aerobic exercise training (AET) may improve central perfusion.To investigate the effects AET on cerebral blood flow (CBF) in patients with amnestic mild cognitive impairment (MCI), a prodromal stage AD.This is proof-of-concept, randomized controlled trial that assigned 70 MCI into 12-month program moderate-to-vigorous or stretching-and-toning (SAT) intervention. Carotid β-stiffness index...
Current evidence is inconsistent on the benefits of aerobic exercise training for preventing or attenuating age-related cognitive decline in older adults.To investigate effects a 1-year progressive, moderate-to-high intensity intervention function, brain volume, and cortical thickness sedentary but otherwise healthy adults.We randomized 73 adults to stretching-and-toning (active control) program. The primary outcome was composite score calculated from eight neuropsychological tests...
Observational evidence suggests that higher physical activity is associated with slower kidney function decline; however, to our knowledge, no large trial has evaluated whether and exercise can ameliorate decline in older adults.
One of the most fundamental adaptive physiological events is response skeletal muscle to high-intensity resistance exercise, resulting in increased protein synthesis and ultimately larger mass. However, growth contraction attenuated older humans. Impaired contractile-induced may contribute sarcopenia: age-associated loss mass function that manifested by strength, contractile capacity, endurance. We hypothesized storage ceramide would be individuals this associated with increases NFκB...
Background.Weakness contributes to the decline of physical function that occurs with aging.Contradictory findings have been reported as whether neuromuscular activation is impaired aging, and extent which it weakness.The present study uses a longitudinal design assess how potential age-related change affects strength, power, mobility function.Methods.Participants included 16 healthy older adults who were high functioning at baseline.Strength was measured by leg press one repetition...
The impact of aerobic exercise training (AET) on cerebral blood flow (CBF) regulation remains inconclusive. This study investigated the effects one-year progressive, moderate-to-vigorous AET CBF, central arterial stiffness, and cognitive performance in cognitively normal older adults. Seventy-three adults were randomly assigned to or stretching-and-toning (SAT, active control) intervention. CBF was measured with 2D duplex ultrasonography. Central by carotid β-stiffness index, assessed...
Abstract The aging U.S. population and the recent rise in prevalence of obesity are two phenomena great importance to public health. In addition, research suggests that midlife body mass index (BMI) is a risk factor for dementia, particularly costly disease, later life. BMI could influence brain health by adversely impacting cerebral white matter. Recently, greater has been associated with lower matter fractional anisotropy (FA), an tissue microstructure, as measured diffusion‐tensor imaging...
Cerebral blood flow (CBF) decreases across the adult lifespan; however, more studies are needed to understand underlying mechanisms. This study measured CBF and cerebrovascular resistance (CVR) using a multimodality approach in 185 healthy adults (21–80 years). Color-coded duplex ultrasonography phase-contrast MRI were used measure CBF, velocity, vessel diameters of internal carotid (ICA) vertebral arteries (VA). arterial spin labeling was brain perfusion. Transcranial Doppler velocity at...
Purpose: Ischemic preconditioning (IPC) has been used to protect myocardial cells against ischemiareperfusion injury and is recently utilized for improving exercise performance.It unknown whether remote IPC (RIPC) tissues not involved in can induce similar improvements what "dose" of necessary performance benefits.This study determined if unilateral bilateral upper limb RIPC improves lower body anaerobic power output.Methods: Using two randomized, sham-controlled, crossover designs, we...
Excessive visceral fat is associated with greater metabolic fluctuation and increased risk for dementia in older adults. The aim of the current study to directly determine impact central adiposity on brain structure at midlife by examining thickness cerebral cortex.High-resolution magnetization-prepared rapid acquisition gradient-echo images were obtained from 103 participants aged 40 60 years (mean [standard deviation] = 49.63 [6.47] years) a 3-T Siemens Skyra scanner. Visceral was measured...
Advanced aging is characterized by reduced cerebral blood flow (CBF) and increased central arterial stiffness. Increased stiffness associated with CBF pulsatility, which detrimental to cerebrovascular integrity. We examined the associations between stiffness, diastolic, systolic, total in healthy cognitively normal subjects (n=163, age 20-81 years, 62% female) who underwent color-coded duplex ultrasonography of internal carotid (ICA) vertebral artery (VA) measure pulsatile CBF. Cerebral...
Vascular dysfunction has been implicated in the onset and progression of Alzheimer's disease (AD), yet relationship arterial stiffening with brain amyloid-β (Aβ) burden at risk patients is unclear.We aimed to determine aortic carotid Aβ amnestic mild cognitive impairment (aMCI), a proposed transitional stage between normal aging AD.Thirty-two older adults aMCI underwent 18Florbetapir PET amyloid imaging ascertain via standardized uptake value ratio (SUVR). Carotid-femoral pulse wave velocity...
Individuals with metabolic syndrome (MetS) exhibit reduced cerebral blood flow. The mechanisms of this reduction remain unknown but arterial stiffening has been implicated as a contributor. We determined if MetS was associated flow at midlife, and so, whether stiffness responsible for mediating their relation.
Background: Central arterial stiffness is an emerging risk factor of age-related cognitive impairment and Alzheimer’s disease (AD). However, the underlying pathophysiological mechanisms remain unclear. Objective: We tested hypothesis that carotid associated with reduced cerebral blood flow (CBF) increased cerebrovascular resistance (CVR) in patients amnestic mild (MCI), a prodromal stage AD. Methods: Fifty-four MCI 24 cognitively normal subjects (CN) similar age sex to underwent measurements...
Hispanics are at increased risk for acquiring cardiovascular factors that contribute to cognitive dysfunction. To compare indices of vascular health with measures cerebral gray matter integrity, 60 middle‐aged Hispanic and non‐Hispanic Caucasian participants were matched across age, sex, years education, mental status. Arterial stiffness was characterized by β‐stiffness index carotid‐femoral pulse wave velocity, magnetic resonance imaging estimated cortical thickness in a priori regions...
Cerebral blood flow (CBF) becomes pulsatile in response to the change perfusion pressure that is regulated by cerebrovascular impedance. In this study, we aimed characterize age-related differences impedance across adult lifespan. Carotid artery [(CAP), via applanation tonometry] and CBF velocity (CBFV) middle cerebral (via transcranial Doppler) were measured 148 healthy adults (21-79 yr, 62% women). Cerebrovascular was quantified using transfer function analysis. Coherence between changes...