Abstract Despite the growing use of independent component analysis (ICA) algorithms for isolating and removing eyeblink‐related activity from EEG data, we have limited understanding how variability associated with ICA uncertainty may be influencing reconstructed signal after eyeblink artifact components. To characterize magnitude this to understand extent which it influence findings within ERP investigations, decompositions data 32 college‐aged young adults were repeated 30 times three...

Type-2 diabetes is associated with an increased risk of dementia, and the underlying mechanism might involve abnormal insulin signaling in brain. The objective this study was to examine association postmortem brain late-life cognitive decline. Among participants Religious Orders Study, a community-based clinical-pathological cohort, 150 deceased autopsied older individuals (75 matched 75 without by age at death, sex, education) had measurements collected prefrontal cortex using ELISA...

Studies of adiposity and cognition's relationship have been highly mixed, depending on points in the lifespan when cognition were measured, primarily with low Black American representation. Therefore, we examined association between (from early to mid-life) mid-life an (BA) White longitudinal cohort address these literature gaps. The Bogalusa Heart Study has followed participants from childhood adulthood since 1973. Adiposity was measured via body mass index (BMI) at roughly biannual visits...

Abstract Despite positive associations between chronic physical activity and memory; we have little understanding of how best to incorporate during the day facilitate consolidation information into memory, nor even time spent physically active relates memory processes. The purpose this investigation was examine relation long-term memory. Ninety-two young adults learned a list paired-associate items were tested on after 12-hour interval which heart rate recorded continuously. Although...

Introduction Effective connectivity (EC), the causal influence that functional activity in a source brain location exerts over target location, has potential to provide different information about network dynamics than (FC), which quantifies synchrony between locations. However, head-to-head comparisons EC and FC from either task-based or resting-state MRI (fMRI) data are rare, especially terms of how they associate with salient aspects health. Methods In this study, 100 cognitively-healthy...

This longitudinal study investigated monthly motor development and physical activity (PA) of infants with without Down syndrome. Gross fine skills (Bayley Scales Infant Development-III) PA (accelerometer) were assessed in 35 at eight time points during infancy. A multivariate mixed model identified when scores diverged between the groups. In syndrome, bivariate correlations changes calculated, analysis variance probed influence early on motor-skill timing. Results indicate that differences...

COVID-19 represents the newest health disparity faced by African Americans (AA). This study assessed impact of on barriers and willingness to participate in research among older AAs. An online survey was sent a nationwide sample 65- 85-year-old AAs between January February 2021. Constant comparison analysis used extract themes. A total 624 completed survey. Approximately 40% participants were willing engage virtual or in-person research. Of individuals who research, >50% spectrum...

Introduction Regular physical activity lowers risk for cognitive decline and neurodegenerative disorders. Older African Americans (AAs) have been underrepresented in trials that increased to improve outcomes. Methods 56 sedentary, older, cognitively healthy AAs (avg. 69.2 ± 3.4 yrs. old) were randomized 1:1 ratio into either a 12-week successful aging group (SAG) or (PAG). Participants SAG attended weekly 60-min educational sessions which topics discussed. PAG supervised twice per week at...

Introduction Glycemic markers throughout life are associated with increased risk of midlife cognitive decline, yet it is unclear whether these associations differ by race and sex. Methods This study used cross-sectional analysis prospectively maintained cohort. 1,295 participants in the Bogalusa Heart Study, a biracial epidemiological cohort located micropolitan area core setting, provided fasting plasma insulin (FPI) glucose (FPG) biannually from 1973 to 2016. Memory, executive function...

Abstract Background Intranasal insulin is a promising treatment for cognitive decline in Alzheimer’s Disease (AD) and mild impairment (MCI). However, intranasal has been shown to promote weight loss, leading concerns about decreased appetite, food intake, unintentional loss as negative side effects among metabolic ingestive behavior of sprays AD MCI patients. But, related intake appetite are not well studied, particularly African American adults who under‐represented research. Method 39...

Abstract Background In functional magnetic resonance imaging (fMRI), a hemodynamic response function describes how neuron firing events are translated into blood oxygenation that is detected through imaging. The HRF varies between individuals and brain regions, its characteristics believed to be valuable biomarkers of neurovascular aspects health. However, the impact cardiovascular risks on among diverse cognitively healthy middle aged older adults not well studied. Method 137 Bogalusa Heart...

Abstract Background In functional magnetic resonance imaging (fMRI), a hemodynamic response function describes how neuron firing events are translated into blood oxygenation that is detected through imaging. The HRF varies between individuals and brain regions, its characteristics believed to be valuable biomarkers of neurovascular aspects health. However, the impact cardiovascular risks on among diverse cognitively healthy middle aged older adults not well studied. Method 137 Bogalusa Heart...

Abstract Background Plasma markers of amyloid, tau, and neurodegeneration (ATN) are promising as correlates AD biological clinical features, but data from older African Americans, on change during non‐pharmacological interventions, is limited. Method The Program for American Cognition Exercise (PAACE) randomized cognitively normal adults into a 12‐week successful aging group (SAG) to attend educational sessions or physical activity (PAG) complete supervised in‐home activity. Repeatable...

Abstract Background Peripheral insulin resistance is associated with increased risk of AD dementia, and postmortem measures reduced signaling in the brain have been linked to poorer cognition AD‐related domains proximal death. However, relationship between longitudinal cognitive decline over years leading up death under‐studied. This study assessed change domain‐specific a clinical‐pathologic, community‐based cohort. Method Using subsample participants Religious Orders Study (75 diabetes...

Abstract Background Greater adiposity in middle age or earlier has been associated with both poorer and greater cognitive functioning late life, as well risk of AD (Buchman et al., 2005; Cournot 2006; Sturman 2008), but prior studies were primarily conducted on populations low African American representation have scarce data adolescent BMI. Therefore, this investigation examined the association between from early life to mid‐life cognition a bi‐racial, semi‐rural Deep Southern...

Abstract Background The association between early‐life glycemic control (during adolescence and young‐adulthood) both cognition risk of AD is not well understood. Furthermore, African Americans (AA) are underrepresented in aging research disproportionally at higher for diseases related to (Chow et al., 2012). This study assessed race sex differences the midlife cognitive function a biracial, semi‐rural, Deep Southern population‐based epidemiological cohort. Method Bogalusa Heart Study has...

Abstract Background Lower levels of physical activity (PA) are associated with greater risk cognitive decline and AD, some studies suggest that interventions increase PA engagement lower AD. However, to date have largely not included substantial representation African Americans. Method The Program for American Cognition Exercise (PAACE) randomized 56 sedentary adults in the Baton Rouge, Louisiana area (mean age ± s.d.: 69.2 3.4 years) a group (PAG) or successful aging (SAG). PAG aimed...