A5101722078- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Biological Activity of Diterpenoids and Biflavonoids
- RNA Research and Splicing
- Phytochemical compounds biological activities
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Hedgehog Signaling Pathway Studies
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Nicotinic Acetylcholine Receptors Study
- Signaling Pathways in Disease
- Genetics and Neurodevelopmental Disorders
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Protein Tyrosine Phosphatases
- Cancer Cells and Metastasis
Shanghai Jiao Tong University
2013-2025
Heidelberg University
2021-2023
DKFZ-ZMBH Alliance
2021-2023
Jinan University
2021
State Key Laboratory of Oncogene and Related Genes
2013-2015
Liaoning University
2012-2013
Shenyang Pharmaceutical University
2012
The role of WNT/β-catenin signalling in mouse neocortex development remains ambiguous. Most studies demonstrate that regulates progenitor self-renewal but others suggest it can also promote differentiation. Here we explore the WNT/STOP signalling, which stabilizes proteins during G2/M by inhibiting glycogen synthase kinase (GSK3)-mediated protein degradation. We show mice mutant for cyclin Y and Y-like 1 (Ccny/l1), key regulators display reduced neurogenesis developing neocortex....
Abstract Purpose: Although a previous study reported nerve ending–derived acetylcholine promoted prostate cancer invasion and metastasis by regulating the microenvironment of cells, present aims to determine whether there is autocrine cholinergic signaling in epithelial cells that promotes growth castration resistance. Experimental design: In this study, IHC was performed detect protein expression mouse tissue sections human sections. Subcutaneously orthotopically xenografted tumor models...
It is widely thought that Wnt/Lrp6 signaling proceeds through the cytoplasm and motile cilia are signaling-inert nanomotors. Contrasting both views, we here show in mucociliary epidermis of X. tropicalis embryos transduce a ciliary Wnt signal distinct from canonical β-catenin signaling. Instead, it engages Wnt-Gsk3-Ppp1r11-Pp1 axis. Mucociliary essential for ciliogenesis Lrp6 co-receptors localize to via VxP targeting sequence. Live-cell imaging using Gsk3 biosensor reveals an immediate...
Androgen receptor (AR) plays a critical role during the development and progression of prostate cancer in which microRNA miR-375 is overexpressed correlated with tumor progression. Although DNA methylation key mechanism for repression gene expression, relationship between AR expression or hypermethylation unknown. In this study, we found that AR-positive (PCa) cells showed high levels hypomethylation miR-375. contrast, AR-negative PCa displayed low Addition 5-Aza-2'-deoxycytidine, specific...
Abstract The supply of platelets for clinical transfusion is often insufficient to meet growing demand. Platelet regeneration from stem cells offers a potential solution reduce reliance on donor‐based transfusions. However, the current differentiation efficiency suboptimal. A novel approach presented that significantly enhances platelet yield hematopoietic and progenitor (HSPCs) by increasing production megakaryocyte progenitors (MkPs) mature megakaryocytes (MKs). This method employs...
Abstract Objectives Storkhead box 1 (STOX1) belongs to the forkhead family of transcription factors, and is reported be involved in apoptosis Caenorhabditis elegans . However, up now precise role STOX1 mammalian epithelial development has not been established. Here, we report that it plays an important regulation proliferation inner ear cells. Materials methods Immunohistochemistry reverse transcription‐PCR assays were used determine expression pattern mouse ear. Furthermore, its...
Current androgen deprivation therapy often leads to independence. However, mechanism of the therapeutic failure is still not well understood. Here, we demonstrate elevated expression Zeb1 in androgen-independent prostate cancer cells and tumors castrated PTEN conditional knockout mice. While shRNA resulted a sensitization cells, forced caused androgen-dependent be more resistant deprivation. Moreover, such effects appeared mediated by induction pluripotent genes or stem cell-like properties....
Significance Despite the extensive attentions paid to phosphatase and tensin homolog (Pten) or SH2-containing tyrosine (Shp2) functions in cell signaling, how their regulated pathways are intertwined has never been investigated. By creating a compound mutant mouse line with both genes deleted blood cells, we have found that Pten Shp2 can work antagonistically myelopoiesis, while acting cooperatively erythropoiesis. Consistently, pharmacological inhibition of suppressed myeloproliferative...
Carya cathayensis is a fruit-bearing plant that belongs to the Juglandaceae family and widely distributed throughout world. It possesses various important biological activities. We have previously isolated an antitumor compound from shell of C. fruits named it E2S ((E)-3-[(2S,3R)-2,3-dihydro-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-1-benzo[b]furan-5-yl]-2-propenal). In this study, we investigated activity against human colorectal cancer cell lines (HCT116, HT29, SW480,...
Microenvironment and cell–cell interactions play an important role during embryogenesis are required for the stemness differentiation of stem cells. The inner-ear sensory epithelium, containing hair cells supporting cells, is derived from within otic vesicle at early embryonic stages. However, whether or not such microenvironment tissue have capacity to regulate proliferation autonomously reassemble into epithelial structures unknown. Here, we report that on enzymatic digestion dissociation...
<div>Abstract<p><b>Purpose:</b> Although a previous study reported nerve ending–derived acetylcholine promoted prostate cancer invasion and metastasis by regulating the microenvironment of cells, present aims to determine whether there is autocrine cholinergic signaling in epithelial cells that promotes growth castration resistance.</p><p><b>Experimental design:</b> In this study, IHC was performed detect protein expression mouse tissue...
<p>Supplementary Figure S3. CHRM3 is up-regulated in CRPC cells.</p>
<p>Supplementary figure legend</p>
<p>Supplementary Figure S1. Analysis of gene expression in Oncomine database and GEO Profiles database.</p>
<p>Supplementary Figure S2. Autocrine activation of CHRM3 promotes cell migration in scratch test.</p>
<div>Abstract<p><b>Purpose:</b> Although a previous study reported nerve ending–derived acetylcholine promoted prostate cancer invasion and metastasis by regulating the microenvironment of cells, present aims to determine whether there is autocrine cholinergic signaling in epithelial cells that promotes growth castration resistance.</p><p><b>Experimental design:</b> In this study, IHC was performed detect protein expression mouse tissue...
<p>Supplementary Figure S1. Analysis of gene expression in Oncomine database and GEO Profiles database.</p>
<p>Supplementary Figure S2. Autocrine activation of CHRM3 promotes cell migration in scratch test.</p>
<p>Supplementary Figure S3. CHRM3 is up-regulated in CRPC cells.</p>