A5051604966- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- melanin and skin pigmentation
- Skin Protection and Aging
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Immune Cell Function and Interaction
- Cutaneous lymphoproliferative disorders research
- Allergic Rhinitis and Sensitization
- Dermatological and Skeletal Disorders
- Spondyloarthritis Studies and Treatments
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Skin and Cellular Biology Research
- Nonmelanoma Skin Cancer Studies
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Colorectal and Anal Carcinomas
- Systemic Lupus Erythematosus Research
- Hidradenitis Suppurativa and Treatments
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Hepatitis B Virus Studies
- Pregnancy and Medication Impact
University of Parma
2015-2024
University of Palermo
2021
Agostino Gemelli University Polyclinic
2020
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2016
Ospedale di Parma
2016
Ospedale Maggiore
2016
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016
Istituti di Ricovero e Cura a Carattere Scientifico
2016
Creative Research Enterprises (United States)
2016
Ospedale "Santa Maria delle Croci" di Ravenna
2016
Abstract Background Few and small studies have described the management of immunomodulant/immunosuppressive therapies or phototherapy in atopic dermatitis (AD) patients during coronavirus disease 2019 (COVID‐19) pandemic. Methods A national registry, named DA‐COVID‐19 involving 35 Italian dermatology units, was established order to evaluate impact COVID‐19 pandemic on adult AD treated with systemic medications phototherapy. Demographic clinical data were obtained at different timepoints by...
UVB irradiation can cause considerable changes in the composition of cells skin and cutaneous cytokine levels. We found that a single exposure normal human to induced an infiltration numerous IL-4(+) cells. This recruitment was detectable papillary dermis already 5 h after irradiation, reaching peak at 24 declining gradually thereafter. The appeared epidermis postradiation reached plateau days 2 3. number markedly decreased both day 4, later time points, IL-4 expression absent. did not...
Abstract Background Acitretin is licensed for and most commonly used to treat psoriasis. Little information exists about its efficacy safety in childhood adolescent Methods Retrospective analysis of a group children adolescents (<17 years age) with moderate severe plaque psoriasis treated acitretin between 2010 2014 at Italian dermatology clinics. Patients were identified through databases or registries. Results The study population consisted 18 patients median age 9.5 the start therapy....
Report of a Case A woman in her 30s presented with hidradenitis suppurativa (HS), Hurley stage II. She was treated oral contraceptives (drospirenone/ethinyl estradiol), spironolactone (50 mg/d), topical clindamycin, andmonthly intralesional corticosteroids (triamcinolone acetonide, 10 mg/mL). Previously, she had received rifampicin (600 first minocycline (100 then clindamycin (300 and finally moxifloxacin (400mg/d). After these treatments failed, isotretinoin (0.5 mg/kg/d) for 2 more years...
Chronic spontaneous urticaria (CSU) is perceived as a difficult to manage disease with negative impact on quality of life. The aim this study was highlight how improve the care people CSU, using methodology narrative medicine. From June 2014 March 2015, CSU-diagnosed patients and their physicians were asked record experiences condition in writing. Fourteen healthcare teams participated: 41% considered CSU challenge overcome, while 22% experienced big commitment. number professional involved...
Dimethyl fumarate (DMF) is a fumaric acid esters derivate approved for plaque psoriasis as first-line systemic therapy. It has been available in Italy since 2017 and an increasing number of patients are treated with this drug. To evaluate DMF effectiveness, side effects drug survival dermatological real-life setting. We performed retrospective multi-center study five dermatologic clinics Emilia-Romagna, Northern Italy, which included all consecutive affected by moderate-severe DMF. assessed...
Background Real-world data for guselkumab, the first interleukin-23 inhibitor approved to treat moderate-to-severe psoriasis, are scarce. This study represents 60-week, real-life, multicenter, retrospective experience investigate effectiveness, safety, tolerability, and drug retention of guselkumab in psoriatic patients.Research design methods Clinical information was collected at baseline weeks 12, 24, 36, 48, 60.Results The mean Psoriasis Activity Severity Index (PASI) reduced from 14.2...
Normal human skin shows preferential (epi)dermal infiltration of CD4+ T cells upon acute UV exposure. To study the mechanism behind this feature we locally exposed healthy volunteers to doses commonly encountered by population. Expression integrins on and expression adhesion molecules dermal endothelial were quantitatively assessed immunohistochemistry in situ. We also investigated effects ultraviolet-B (UVB) exposure psoriasin IL-16, two specific chemoattractant factors for cells, at...
We have prospectively evaluated psoriatic arthritis (PsA) patients for (1) seropositivity former viral infections and seroconversion (2) efficacy of cyclosporine A (CsA) alone or in combination with other immunosuppressants a time period 12 months. Screening included HBV antibodies antigens, HCV RNA, HSV 1-2, HZV, EBV, CMV IgG, IgM, HHV-6 DNA, HIV 1-2 antibodies. PsA was by the Psoriasis Area Severity Index (PASI), Bath Ankylosing Spondylitis Disease Activity (BASDAI), Visual Analogue Scale...
Summary Bexarotene is approved for the treatment of cutaneous T cell lymphomas in patients refractory to at least one prior systemic therapy. Associated hypertriglyceridaemia requires monitoring, but can readily be managed with concomitant medication, such as fenofibrate. Here we report three cases secondary bexarotene assumption, which was adequately omega‐3 fatty acids. If fenofibate‐related side effects occur, or a statin required control low‐density lipoprotein‐cholesterol, acids should...
This study aimed to evaluate the prevalence of sunbed use among teenagers and association between familial behavior adoption UV-protective practices in this age group. We also assessed impact an educational program on students' knowledge about potential risks use. The intervention focused on: (i) skin effects UV radiation, (ii) photoaging photocarcinogenesis, (iii) risk factors for cancer, (iv) indoor sun tanning misleading concepts such as possible protective effect cancer risk, (v)...
Vitiligo is a disease characterized by the loss of melanocytes, resulting in progressive depigmentation skin, and areas normally pigmented skin can be cosmetic concern. Several options have been tried to remove pigment make more even colour. We present an easy effective therapeutic procedure based on single‐session cryotherapy followed topical 4‐hydroxyanisole (4‐HA).
Photodynamic therapy with 5-methyl-aminolevulinate and photodynamic trichloroacetic acid 50% are the two techniques utilized in management of actinic keratosis. This study was planned to compare efficacy, adverse effects, recurrence cosmetic outcome these option therapies patients multiple keratosis scalp.Thirteen were treated one treatments on half scalp at baseline, while other treatment performed 15 days apart, randomly. Efficacy, recorded follow-up visit 1, 3, 6 12 months.Photodynamic 5...
The proportion and composition of the human cutaneous CD3+ T lymphocyte population was determined in situ following a single exposure to physiological, erythema-inducing doses simulated solar radiation, mainly consisting UV radiation. Biopsies were taken 1, 2 7 days after local irradiation normal volunteers with 4 MED by xenonarc lamp immunohistochemistry performed on cryostat sections. Ultraviolet radiation caused an initial decrease intraepidermal T-cell numbers or even could lead...
Treatment of patients with psoriasis and concomitant hepatitis-C virus (HCV) infection poses a therapeutic challenge because most systemic drugs are associated potential hepatotoxicity, either due to direct liver damage or immunosuppression. Among newly available for the treatment psoriatic arthritis, studies investigating effect anti-tumour necrosis factor-α in such still limited. We describe three HCV, one alcoholic hepatitis, who were treated etanercept monotherapy six months. obtained...
Abstract Background Notalgia paresthetica ( NP ) is a disorder characterized by pruritus localized to the patient's back. Little known about predictors of severity, duration, side, and localization. Objective To identify factors associated with perceived localization . Methods In cross‐sectional study, disease were compared among considered variables. Multivariate analysis was used assess each variable contribution in predicting severity its duration. Results Sixty‐five patients recruited....