A5006303992- Dementia and Cognitive Impairment Research
- Origins and Evolution of Life
- Neurobiology of Language and Bilingualism
- Sustainability and Ecological Systems Analysis
- Cognitive Functions and Memory
- Spatial Neglect and Hemispheric Dysfunction
- Evolutionary Game Theory and Cooperation
- Functional Brain Connectivity Studies
- Advanced Thermodynamics and Statistical Mechanics
- Embodied and Extended Cognition
- Neurological Disorders and Treatments
- Space Science and Extraterrestrial Life
- Memory and Neural Mechanisms
- Metabolism and Genetic Disorders
- Neural and Behavioral Psychology Studies
- Complex Systems and Decision Making
- Spatial Cognition and Navigation
- semigroups and automata theory
- Intestinal Malrotation and Obstruction Disorders
- EEG and Brain-Computer Interfaces
- Plant and Biological Electrophysiology Studies
- Cognitive and developmental aspects of mathematical skills
- Alzheimer's disease research and treatments
- Art, Technology, and Culture
- Pharmacological Effects and Toxicity Studies
University of North Dakota
2009-2024
University of Connecticut
1991-2024
Sanford Medical Center
2014
Rowan University
2005
Institute for Complex Systems
2005
Diabetes Care Center
1996-2001
Abstract By Boltzmann's widely accepted reduction of the second law to a stochastic collision function, transformations from an incoherent coherent state are ‘infinitely improbable’. Yet it is precisely transformation into coherent, progressive emergence new levels macroscopic constraints, that has brought, and continues bring, visible universe being. Whether in ecosystem succession, hydrodynamic structures, morphogenesis, 4GY bioevolution, cognitive cultural evolution, or cosmic evolution...
An argument is developed to show that the origin and evolution of perceptual guidance movements movement enhancement opportunities perceive, is, perception-action cycles, have a direct deep connection with thermodynamic principles. The cornerstones are: (a) maximum entropy production as physical selection principle (thermodynamic fields will behave in such fashion get final state-minimize field potential or maximize entropy-at fastest possible rate given constraints); (b) inexorability order...
In a previous article we described 10-point scoring system (i.e., scale 1) to grade clock drawings command and copy with hands set for "ten after 11" among demented patients. Alzheimer's subjects (AD) improved from the conditions, whereas ischaemic vascular dementia (IVD) did not. To investigate underlying cognitive deficits responsible this profile, an additional was developed (scale 2) that tallied errors in graphomotor functioning, hand/number placement, executive control. On independent...
Abstract A group of 94 nondemented patients self-referred to an outpatient memory clinic for difficulties were studied determine the incidence single versus multi-domain mild cognitive impairment (MCI) using Petersen criteria. Fifty-five community dwelling normal controls (NC) participants without complaints also recruited. Tests assessing executive control, naming/lexical retrieval, and declarative administered. Thirty-four exhibited single-domain MCI, 43 presented with MCI. When entire MCI...
Using cluster analysis Libon et al. (2010) found three verbal serial list-learning profiles involving delay memory test performance in patients with mild cognitive impairment (MCI). Amnesic MCI (aMCI) presented low scores on free recall and recognition tests; mixed (mxMCI) scored higher compared to dysexecutive (dMCI) generated relatively intact both conditions. The aim of the current research was further characterize by examining forgetting/savings, interference from a competing word list,...
Modem science has been built on a Cartesian or Newtonian (mechanical) world view giving rise to an artifactual of mind and suggesting that particles (learners) are continuously working destroy order (are recalcitrant), which can only be maintained by external artificer (the teacher). At the core worldview is absolute separation matter. Beginning with body, Cartesianism grounded in set dualisms separate individual from environment leads belief knowledge refers self-sufficient immaterial...
Background:Digital Clock Drawing Test (dCDT) technology enables the examination of detailed neurocognitive behavior as unfolds in real time; a capability that cannot be obtained using traditional pen and paper testing format. Objective:Parameters from dCDT were used to inves tigate constructs related higher-order decision making information processing speed. The current research sought determine effect age combined motor non-motor components drawing, latencies. Methods:A large group stroke-...
Autopoiesis was introduced into the literature by Maturana and Varela as name for a particular system description which they claimed necessary sufficient to define living also explain it. The term has been widely applied in instead spontaneous order production or self-organization general, whether not. Zeleny Hufford, authors of focal paper this volume, would like continue tradition. While their effort seek generic behavior is be commended, move must rejected. In first place, if concept...
Epidemiologic autopsy studies show mixed Alzheimer's disease (AD)/vascular pathology in many patients. Moreover, clinical research shows that it is not uncommon for AD and vascular dementia (VaD) patients to be equally impaired on memory, executive, or other neurocognitive tests. However, this heterogeneity has been incorporated into the new diagnostic criteria (Dubois et al., 2010; McKhann 2011).The current applied Latent Class Analysis (LCA) a protocol of six neuropsychological parameters...
Introduction Alzheimer’s disease and related dementias (ADRD) represent a substantial global public health challenge with multifaceted impacts on individuals, families, healthcare systems. Brief cognitive screening tools such as the Mini-Cog© can help improve recognition of ADRD in clinical practice, but widespread adoption continues to lag. We compared Digital Clock Recall (DCR), next-generation process-driven adaptation Mini-Cog, original paper-and-pencil version well-characterized trial...
Abstract: The “hard problem” of the origin and nature intelligence (cognition/“mind”) in cosmos its relation to symmetry breaking goes back Pre-Socratic Parmenides who claimed true reality (ontology) was a state perfect world change we know an illusion. problem that his ideal broken ab initio by cognitive act him asserting it. This incommensurable separation time-asymmetric part physics came into modern science with Cartesian dualism time-symmetric equations Newton then measurement quantum...
Abstract Libon et al. (2010) provided evidence for three statistically determined clusters of patients with mild cognitive impairment (MCI): amnesic (aMCI), dysexecutive (dMCI), and mixed (mxMCI). The current study further examined in MCI using the framework Fuster's (1997) derailed temporal gradients, that is, declining performance on executive tests over time or test epoch. Temporal gradients were operationally defined by calculating slope aggregate letter fluency output across 15-s epochs...
Background Digital neuropsychological tests reliably capture real-time, process-based behavior that traditional paper/pencil cannot detect, enabling earlier detection of neurodegenerative illness. We assessed relations between informant-based subtle and mild functional decline features extracted from the digital Trail Making Test-Part B (dTMT-B). Methods A total 321 community-dwelling participants (56.0% female) were with Functional Activities Questionnaire (FAQ) dTMT-B. Three FAQ groups...
Over its 4.6 billion year history, the time-dependent behavior of planet Earth, from origin and emergence life to explosive globalization human culture today, shows progressive accelerating production increasingly more highly ordered dynamic states. Understanding our place as both productions producers in this rapidly global becoming is a requisite step meaningful grounding virtually every other discipline, most particularly those disciplines relating endeavors activities humans themselves....
Abstract Objective: To determine whether the DCTclock can detect differences across groups of patients seen in memory clinic for suspected dementia. Method: Patients ( n = 123) were classified into following groups: cognitively normal (CN), subtle cognitive impairment (SbCI), amnestic (aMCI), and mixed/dysexecutive (mx/dysMCI). Nine outcome variables included a combined command/copy total score four command copy indices measuring drawing efficiency, simple/complex motor operations,...
The introduction of diagnostic criteria for vascular dementia has helped to re-define the impact various subcortical neuropathologies on aging; however, state-of-the-art neuroimaging techniques and autopsy studies suggest that not all structural brain alterations associated with are exclusive this neurodegenerative process alone. Thus, a detailed analysis cognitive phenotype ischaemic disease is key our understanding neuropathology its behaviors. Over past twenty years, we have operationally...
Introduction Screening for neurocognitive impairment and psychological distress in ambulatory primary specialty care medical settings is an increasing necessity. The Core Cognitive Evaluation™ (CCE) administered/scored using iPad, requires approximately 8 min, assesses 3- word free recall clock drawing to command copy, asks questions about lifestyle health, queries distress. This information linked with patients’ self- reported concerns memory their cardiovascular risks. Methods A total of...