A5042496555- Transcranial Magnetic Stimulation Studies
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Health, Environment, Cognitive Aging
- Cognitive Functions and Memory
- Pain Management and Treatment
- Neurological disorders and treatments
- Technology and Human Factors in Education and Health
- Cancer-related cognitive impairment studies
- Neuroscience and Neural Engineering
- Hearing Loss and Rehabilitation
- Intensive Care Unit Cognitive Disorders
- Healthcare Systems and Reforms
- Vestibular and auditory disorders
- Pharmacological Effects and Toxicity Studies
- Motor Control and Adaptation
- Neurobiology of Language and Bilingualism
- Epilepsy research and treatment
Harvard University
2017-2025
Boston Children's Hospital
2019-2024
Linus (Norway)
2024
Christus Health
2024
Boston University
2020-2024
Berenson Allen Center for Noninvasive Brain Stimulation
2016-2023
Beth Israel Deaconess Medical Center
2016-2023
Beth Israel Deaconess Hospital
2019-2023
Imaging Center
2023
Simon Fraser University
2010-2022
Salient distractors delay visual search for less salient targets in additional-singleton tasks, even when the features of stimuli are fixed across trials. According to salience-driven selection hypothesis, this is due an initial attentional deployment distractor. Recent event-related potential (ERP) studies found no evidence fixed-feature search, but methods employed were not optimized isolate distractor ERP components such as N2pc and positivity (PD; indices suppression, respectively)....
BackgroundOver the past decade, number of experimental and clinical studies using theta-burst-stimulation (TBS) protocols transcranial magnetic stimulation (TMS) to modulate brain activity has risen substantially. The use TBS is motivated by assumption that these can reliably lastingly cortical excitability despite their short duration low stimuli. However, this assumption, thus validity TBS, challenged recent work showing large inter- intra-subject variability in response...
Abstract Background Disease-modifying treatments for Alzheimer’s disease highlight the need early detection of cognitive decline. However, at present, most primary care providers do not perform routine testing, in part due to a lack access practical assessments, as well time and resources administer interpret tests. Brief sensitive digital such Digital Clock Recall (DCR™), have potential address this need. Here, we examine advantages DCR over Mini-Mental State Examination (MMSE) detecting...
The presence of a salient distractor interferes with visual search. According to the salience-driven selection hypothesis, this interference is because an initial deployment attention distractor. Three event-related potential (ERP) findings have been regarded as evidence for hypothesis: (a) distractors were found elicit ERP component called N2pc, which reflects attentional selection; (b) target and on opposite sides, N2pc was reported precede (N2pc flip); (c) slow-response trials occur...
Background. Transcranial magnetic stimulation (TMS) can be used to assess neurophysiology and the mechanisms of cortical brain plasticity in humans vivo. As use these measures specific population (e.g., Alzheimer's disease; AD) increases, it is critical understand their reproducibility (i.e., test-retest reliability) populations interest. Objective. Reproducibility TMS was evaluated older adults, including healthy, AD, Type-2 diabetes mellitus (T2DM) groups. Methods. Participants received...
Abstract INTRODUCTION Early detection of Alzheimer's disease and cognitive impairment is critical to improving the healthcare trajectories aging adults, enabling early intervention potential prevention decline. METHODS To evaluate multi‐modal feature sets for assessing memory impairment, selection subsequent logistic regressions were used identify most salient features in classifying Rey Auditory Verbal Learning Test‐determined impairment. RESULTS Multimodal models incorporating graphomotor,...
Objectives: This study was conducted to evaluate the effect of simvastatin (40 mg/day) as an adjuvant therapy interferon beta (IFNb 1a, 30 µg once weekly) in relapsing—remitting multiple sclerosis patients, compared with placebo. Methods: We enrolled 85 patients (71% female) who were already receiving IFNb 1a (Avonex), Expanded Disability Status Scale score less than 5.0. The assigned (in random and double-blinded fashion) into two groups All continued receive their current treatment....
Objectives: The utility of continuous theta-burst stimulation (cTBS) as index cortical plasticity is limited by inadequate characterization its test-retest reliability. Thus, we evaluated the reliability cTBS aftereffects, and explored roles age, brain-derived neurotrophic factor (BDNF) apolipoprotein E (APOE) polymorphisms. Methods: 28 healthy adults (age range 21–65) underwent two identical sessions (median interval = 9.5 days) targeting motor cortex. Intraclass correlation coefficients...
Abstract Theta-burst stimulation (TBS) is a patterned form of repetitive transcranial magnetic (rTMS) that has been used to induce long-term modulation ( plasticity ) corticospinal excitability in drastically shorter duration protocol than conventional rTMS protocols. In this study we tested the reliability effects two well defined TBS protocols, continuous (cTBS) and intermittent (iTBS), especially relation sham TBS, within across same 24 participants. All protocols were repeated after...
Introduction Alzheimer’s disease and related dementias (ADRD) represent a substantial global public health challenge with multifaceted impacts on individuals, families, healthcare systems. Brief cognitive screening tools such as the Mini-Cog© can help improve recognition of ADRD in clinical practice, but widespread adoption continues to lag. We compared Digital Clock Recall (DCR), next-generation process-driven adaptation Mini-Cog, original paper-and-pencil version well-characterized trial...
Exercise-mediated cognitive improvements can be at least partly attributed to neuroplastic changes in the nervous system, and may influenced by Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) gene. Transcranial magnetic stimulation (TMS) used assess mechanisms plasticity humans noninvasively.