A5004467371- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Renal and related cancers
- Circular RNAs in diseases
- Cancer therapeutics and mechanisms
- Sesquiterpenes and Asteraceae Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Beetle Biology and Toxicology Studies
- MicroRNA in disease regulation
- Nutritional Studies and Diet
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Advanced Proteomics Techniques and Applications
- Galectins and Cancer Biology
- Medicinal plant effects and applications
- Marine Sponges and Natural Products
- Virus-based gene therapy research
- Histone Deacetylase Inhibitors Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Dermatological diseases and infestations
- Mass Spectrometry Techniques and Applications
- Chemokine receptors and signaling
- Plant-Derived Bioactive Compounds
Yichang Central People's Hospital
2024
China Three Gorges University
2024
State Key Laboratory of Pharmaceutical Biotechnology
2023
University of Hong Kong
2023
Chinese University of Hong Kong
2023
Meizhou City People's Hospital
2018-2021
University of Macau
2017
Sun Yat-sen University
2017
Southern Medical University
2011-2013
Nanfang Hospital
2012-2013
Aspergillosis is a life-threatening fungal infection in immunocompromised people, including people infected with human immunodeficiency virus (HIV). We determined the incidence of aspergillosis among HIV-infected and survival after diagnosis by use national HIV surveillance database. Among 35,252 patients, was 3.5 cases per 1000 person-years (p-y; 95% confidence interval [CI], 3.0-4.0 p-y). Incidence higher aged > or =35 years (4.1 p-y, CI, 3. 5-4.8), CD4 counts 50-99 cells/mm(3) (5.1...
The definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein 1 (sCDCP1) as a top-ranked non-invasive biomarker for NASH using Olink-based proteomics in 238 obese individuals with biopsies. Both the circulating concentration hepatic mRNA abundance sCDCP1 were significantly elevated patients correlated closely each histological feature NASH. In pooled multicenter...
Enhancer RNAs are a subclass of long non-coding transcribed from enhancer regions that play an important role in the transcriptional regulation genes. However, their kidney renal clear cell carcinoma (KIRC) is largely unknown. Herein, we identified key KIRC via integrated data analysis method. Gene expression profiles and clinical 32 other cancer types were acquired using University California Santa Cruz Xena platform. Reported genes regulated by them selected as putative RNA-target pairs....
Renal cell carcinoma (RCC) is the second most common human urinary tumor. Eupatilin main active ingredient of traditional Chinese medicine Artemisia asiatica . The effect on RCC and underlying mechanism remain unknown. Here, we investigated anticancer effects mechanisms in vivo vitro , laying an experimental foundation for clinical application treatment RCC. results showed that significantly inhibited 786-O viability migration promoted apoptosis. expression miR-21 cells, overexpression...
Among all types of kidney diseases, renal cell carcinoma (RCC) has the highest mortality, recurrence and metastasis rates, which results in high numbers tumor‑associated mortalities China. Identifying a novel therapeutic target attracted increasing attention. Bromodomain extraterminal domain (BET) proteins have ability to read epigenome, leading regulation gene transcription. As an important member BET family, bromodomain testis‑specific protein (BRDT) been well studied; however, mechanism...
Cdc6, an essential initiation protein for DNA replication, also participates in the ATR checkpoint pathway and plays a vital role tumorigenesis. It is involved androgen receptor (AR) signal transduction promotes malignant progression of prostate cancer (PCa). In this study, we report that norcantharidin (NCTD) induces degradation Cdc6 DU145 PCa cells as result, assembly pre-replication complexes (pre-RCs) was disturbed replication inhibited. Furthermore, treatment with NCTD blocked binding...
Norcantharidin (NCTD) is currently used for anticancer therapy but the exact mechanism of action remains unknown. Pre-replicative complexes (pre-RCs) are essential cell DNA replication and highly related to malignant proliferation. Here, we examined inhibitory effect NCTD on pre-RC components in HepG2 cells. We showed that induced degradation Cdc6 Mcm2 a dose-dependent manner. Under 100 μM concentration, about 70% 50% were degraded. In addition, nuclear translocation Mcm6 was inhibited by...
MicroRNAs (miRs) are endogenous, single-stranded, noncoding RNAs that involved in various physiological processes, and the development progression of types cancer. Specifically, role miR-200a-3p has been implicated cancer contributing to a diverse array previously reported. The present study aimed investigate expression levels human bladder cancer, as well its potential disease pathogenesis.Reverse transcription-polymerase chain reaction (RT-PCR) Western blot were used detect has-mir-200a-3p...
Clear cell renal carcinoma (ccRCC) is the most common and aggressive type of primary kidney cancer worldwide. Transmembrane protein 45A (TMEM45A) has been reported to be closely associated with progression several cancers. However, role TMEM45A in ccRCC remains unclear. Our study intended explore potential ccRCC.Data on expression were obtained from multiple databases, including UCSC, GEPIA2, Oncomine TIMER. Real-world samples paired normal tissues used confirm information databases. In...
Kidney renal clear cell carcinoma (KIRC) is the most common subtype of kidney cancer. Inorganic pyrophosphatase (PPA2) an enzyme that catalyzes hydrolysis pyrophosphate to inorganic phosphate; few studies have reported its significance in cancers. Therefore, we aimed explore prognostic value PPA2 KIRC.PPA2 expression was detected via immunohistochemistry a tissue chip containing specimens from 150 patients with KIRC. We evaluated correlation between expression, clinicopathological...
Lung cancer is considered the most ubiquitous malignant form of cancer, and current treatment strategies do not offer effective outcomes to patients. The present study examined effectiveness natural drugs delphinidin (DN) oroxylin A (OA) in inhibiting development lung cells (A549) through blocking Signal transducer activator transcription 3 (STAT3) focal adhesion kinase (FAK) intervene signaling pathways. These included cytotoxicity assessments, reactive oxygen species (ROS) levels,...
Background & Aims: Non-alcoholic steatohepatitis (NASH) the inflammatory form of non-alcoholic fatty liver disease (NAFLD) associates with an increased risk progression to liver-related mortality. However, definitive diagnosis NASH relies on invasive and labour-intensive biopsy. This study aimed identify novel circulating biomarkers for develop a non-invasive test identification stratification NASH.Methods: Serum samples from omics cohort comprising 238 individuals biopsy-based histological...
Objective To investigate the molecular mechanism of Eupatilin in inhibiting proliferation renal cell carcinoma (RCC) . Methods The influence on viability RCC was evaluated by MTT assay. The apoptosis induced measured flow cytometry analysis. invasion cells Transwell. miR-21 level Q-PCR. After over-expression miR-21, effects and proliferation, apoptosis, human 786-O were detected MTT, cytometry, Transwell, respectively. protein levels AKT, p-AKT, Bax, Bcl2 examined western blot...
Abstract Background Several studies have shown prognostic value of gene-based models at mRNA level in kidney renal clear cell carcinoma (KIRC). However, protein-based for prognosis prediction KIRC are rarely reported, then we conduct this study. Methods Proteomics and clinical data were acquired from The Cancer Proteome Atlas (TCPA) Genome (TCGA), respectively. Prognosis-associated proteins screened by univariate Cox regression analysis log-rank test. Patients grouped into training set...
Abstract Background MicroRNAs (miRs) are endogenous, single-stranded, non-coding RNAs that involved in various physiological processes, development and the progression of types cancer. The role miR-200a-3p cancer has been previously reported. present study aimed to investigate expression levels human bladder cancer, as well its potential disease pathogenesis. Methods In vitro: Agilent miRNA microarray QPCR analysis Gene overexpression interference technology effects de-ubiquituination enzyme...