A5051377712- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Immune responses and vaccinations
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Complement system in diseases
- Platelet Disorders and Treatments
- interferon and immune responses
- Ocular Diseases and Behçet’s Syndrome
- Head and Neck Surgical Oncology
- Retinal and Optic Conditions
- Child Nutrition and Water Access
- Healthcare and Venom Research
- Inflammasome and immune disorders
- Liver Disease and Transplantation
- Viral Infections and Outbreaks Research
Cairo University
2014-2024
Centre Hospitalier de l’Université de Montréal
2008-2024
Université de Montréal
2008-2024
Emory University
2022-2024
Translational Therapeutics (United States)
2019-2023
University of Pennsylvania
2017-2023
Parker Institute for Cancer Immunotherapy
2019-2020
Institute of Immunology
2017
University of Alberta
2017
Hôpital Saint-Luc
2008-2016
An early memory CD8 + T cell precursor with distinct genome maintenance capacity depends on inhibitory receptor signaling.
Patients with COVID-19 present a wide variety of clinical manifestations. Thromboembolic events constitute significant cause morbidity and mortality in patients infected SARS-CoV-2. Severe has been associated hyperinflammation pre-existing cardiovascular disease. Platelets are important mediators sensors inflammation directly affected by stressors. In this report, we found that platelets from severely ill, hospitalized exhibited higher basal levels activation measured P-selectin surface...
ABSTRACT The majority of acute hepatitis C virus (HCV) infections progress to chronicity and progressive liver damage. Alpha interferon (IFN-α) antiviral therapy achieves the highest rate success when IFN-α is administered early during phase, but underlying mechanisms are unknown. We used a panel major histocompatibility complex class I tetramers monitor phenotypic functional signatures HCV-specific T cells HCV infection with different outcomes IFN therapy. demonstrate that spontaneous...
Abstract The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 8 initiating anti-viral response. Here we demonstrate that genomic RNA harbours specific sequences initiate anti-HCV response through TLR7 TLR8 various antigen presenting cells. Conversely, particles are detected by macrophages, but not monocytes DCs, TLR7/8 dependent mechanism; this leads chloroquine...
The transcriptional programs that regulate CD8 T-cell differentiation and function in the context of viral infections or tumor immune surveillance have been extensively studied; yet how long noncoding RNAs (lncRNAs) loci transcribe them contribute to regulation T cells during remains largely unexplored. Here, we report transcription lncRNA Morrbid is specifically induced by receptor (TCR) type I IFN stimulation early stages acute chronic lymphocytic choriomeningitis virus (LCMV) infection....
Early alpha interferon (IFN-alpha) therapy against hepatitis C virus (HCV) rescues polyfunctional, virus-specific memory CD8(+) T cells, but whether immune restoration is possible during late remains controversial. We compared of HCV-specific cells in patients who cleared HCV infection spontaneously and following early or IFN therapy. Multifunctional CD4(+) were detected spontaneous resolvers individuals treated an acute infection. In contrast, limited responses chronic infection, the...
Type 2 diabetes mellitus (T2DM) is a major global health concern. It usually develops gradually and frequently preceded by undetectable pre-diabetes (pre-DM) stage. The purpose of this study was to identify novel set seven candidate genes associated with the pathogenesis insulin resistance (IR) pre-DM, followed their experimental validation in patients' serum samples.We used bioinformatics tools through two-step process, we first identified verified two mRNA linked molecular pathogenesis....
The dynamics of the memory CD8 T cell receptor (TCR) repertoire upon virus re-exposure and factors governing selection TCR clonotypes conferring protective immunity in real life settings are poorly understood. Here, we examined functionality virus-specific before, during after hepatitis C (HCV) reinfection patients who spontaneously resolved two consecutive infections (SR/SR) a primary but failed to clear subsequent infection (SR/CI). was narrower prior SR/SR group as compared SR/CI became...
The concerted actions of the CNS and immune system are essential to coordinating outcome neuroinflammatory responses. Yet, precise mechanisms involved in this crosstalk their contribution pathophysiology diseases largely elude us. Here, we show that CNS-endogenous hedgehog pathway, a signal triggered as part host response during inflammatory phase multiple sclerosis experimental autoimmune encephalomyelitis, attenuates pathogenicity human mouse effector CD4 T cells by regulating production...
Direct acting antivirals against hepatitis C virus (HCV) have markedly improved cure rates in the past few years. However, they are expensive, with only targeting host cell factors, and affecting assembly release. Huh7.5 cells infected a JFH-1 clone of HCV were treated two different glycogen synthase kinase (GSK3)-β inhibitors; AR-A014418 lithium chloride. Intra- extracellular virions specific infectivity was determined using real-time RT-PCR TCID50, changes lipid production identified by...
Abstract The regulatory circuits dictating CD8 + T cell responsiveness versus exhaustion during anti-tumor immunity are incompletely understood. Here we report that tumor-infiltrating antigen-specific PD-1 TCF-1 − cells express the immunosuppressive cytokine Fgl2. Conditional deletion of Fgl2 specifically in mouse prolongs persistence, suppresses phenotypic and transcriptomic signatures exhaustion, improves control tumor. In a model chronic viral infection, cell-derived also negatively...
Significance CD8 T cell exhaustion is a key underlying factor limiting immunity in chronic infections and cancer. Persistent antigen exposure antagonizes formation of functional memory cells that provide long-term protection and, instead, drives the development exhausted (T EX ). Improving persistence function major goal for reinvigorating immune responses against tumors. Here, we identify miR-29a as molecule attenuates enhances . Enforced expression alters transcriptome, resulting robust...
Abstract Rewiring exhausted CD8 T cells (T EX ) towards more functional states is a major goal of cancer immunotherapy but has proven challenging due to the epigenetic stability . Indeed, are epigenetically programmed by transcription factor Tox. However, changes continue occur as transition from progenitor prog ), intermediate int and terminal term subsets, suggesting potential developmental flexibility in mature subsets. By examining into cells, we discovered reciprocally antagonistic...
Introduction Follicular helper T cells are essential for helping in the maturation of B and production neutralizing antibodies (NAbs) during primary viral infections. However, their role recall responses is unclear. Here, we used hepatitis C virus (HCV) reinfection humans as a model to study collaborative interaction between circulating CD4 follicular (cTfh) memory (MBCs) leading generation NAbs. Methods We evaluated this longitudinally subjects who have spontaneously resolved HCV infection...
Abstract Patients with COVID-19 present a wide variety of clinical manifestations. Thromboembolic events constitute significant cause morbidity and mortality in patients infected SARS-CoV-2. Severe has been associated hyperinflammation pre-existing cardiovascular disease. Platelets are important mediators sensors inflammation directly affected by stressors. In this report, we found that platelets from severely ill, hospitalized exhibit higher basal levels activation measured P-selectin...