A5013548886- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Escherichia coli research studies
- Influenza Virus Research Studies
- interferon and immune responses
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
University of Alberta
2014-2022
Article20 July 2015Open Access Source Data Chimeric adaptor proteins translocate diverse type VI secretion system effectors in Vibrio cholerae Daniel Unterweger Department of Medical Microbiology and Immunology, University Alberta, Edmonton, AB, Canada Search for more papers by this author Benjamin Kostiuk Rina Ötjengerdes Ashley Wilton Laura Diaz-Satizabal Stefan Pukatzki Corresponding Author Information Unterweger1, Kostiuk1, Ötjengerdes1, Wilton1, Diaz-Satizabal1 1 1Department...
The causative agent of cholera, Vibrio cholerae, regulates its diverse virulence factors to thrive in the human small intestine and environmental reservoirs. Among this pathogen's arsenal is tightly regulated type VI secretion system (T6SS). This acts as an inverted bacteriophage inject toxins into competing bacteria eukaryotic phagocytes. V. cholerae strains responsible for current 7th pandemic activate their T6SS within host. We established that T6SS-mediated competition occurs upon...
Ducks, the reservoir host, are generally permissive to influenza A virus infection without disease symptoms. This natural ecology was upset by emergence of H5N1 strains, which can kill ducks. To better understand host-virus interactions in and strain-specific molecular contributions virulence, we infected White Pekin ducks with three similar viruses, known differences pathogenicity replication rate. We quantified viral innate immune gene activation qPCR, lung spleen tissues, isolated on each...
Abstract The gram-negative bacterium Vibrio cholerae is the causative agent of diarrhoeal disease cholera and responsible for seven recorded pandemics. Several factors are postulated to have led decline 6th pandemic classical strains rise El Tor biotype V. , establishing current 7th pandemic. We investigated ability 2nd pandemics engage their type six secretion system (T6SS) in microbial competition against non-pandemic strains. report that underwent sequential mutations T6SS genetic...
Abstract MHC class I is critically involved in defense against viruses, and diversity from polygeny polymorphism contributes to the breadth of immune response health population. In this article, we examine wild mallard ducks, natural host reservoir influenza A viruses. We previously showed domestic ducks predominantly use UAA, one five genes, but whether biased expression also true for mallards unknown. Using RT-PCR blood, examined expressed alleles 38 (Anas platyrhynchos) identified 61...